Affinity purified antibodies to human interferon gamma
◊ Lozenges from white to almost white, flat-cylindrical shape, with a notch and a chamfer; on the flat side with a mark there is the inscription MATERIA MEDICA, on the other flat side there is the inscription ANAFERON.
* applied to lactose monohydrate in the form of a water-alcohol mixture containing no more than 10 -15 ng/g of the active form of the active substance.
Excipients: lactose monohydrate - 0.267 g, microcrystalline cellulose - 0.03 g, magnesium stearate - 0.003 g.
20 pcs. - contour cellular packaging (1) - cardboard packs.
20 pcs. - contour cell packaging (2) - cardboard packs.
20 pcs. - contour cell packaging (5) - cardboard packs.
With preventive and medicinal use the drug has immunomodulatory and antiviral effect. Experimentally and clinically established effectiveness against influenza viruses, parainfluenza viruses herpes simplex Types 1 and 2 (labial herpes,), other herpes viruses ( chicken pox, infectious mononucleosis), enteroviruses, virus tick-borne encephalitis, rotavirus, coronavirus, calicivirus, adenovirus, respiratory syncytial virus (RS virus). The drug reduces the concentration of the virus in the affected tissues, affects the system of endogenous interferons and associated cytokines, induces the formation of endogenous “early” interferons (IFN α/β) and interferon gamma (IFN γ).
Stimulates the humoral and cellular immune response. Increases the production of antibodies (including secretory IgA), activates the functions of T-effectors, T-helpers (Tx), normalizes their ratio. Increases the functional reserve of Tx and other cells involved in the immune response. It is an inducer of a mixed Tx1- and Th2-type immune response: it increases the production of Th1 (IFN γ, IL-2) and Th2 (IL-4, 10) cytokines, normalizes (modulates) the balance of Th1/Th2 activities. Increases the functional activity of phagocytes and natural killer cells (NK cells). Has antimutagenic properties.
The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content active ingredients the drug Anaferon in biological fluids, organs and tissues, which makes it technically impossible to study pharmacokinetics.
The drug is taken orally, not during meals. The tablet should be kept in the mouth until completely dissolved.
ARVI, flu, intestinal infections, herpesvirus infections, neuroinfections
On the 1st day take 8 tablets. according to the following scheme: 1 tab. every 30 minutes in the first 2 hours (total 5 tablets in 2 hours), then during the same day take another 1 tablet. 3 times at equal intervals. On the 2nd day and further, take 1 tablet. 3 times a day until complete recovery.
If there is no improvement on the 3rd day of treatment with the drug for acute respiratory viral infections and influenza, you should consult a doctor.
IN epidemic season with for preventive purposes The drug is taken daily 1 time/day for 1-3 months.
Genital herpes
At acute manifestations genital herpes the drug is taken at regular intervals according to the following scheme: 1-3 days - 1 tablet. 8 times/day, then 1 tablet. 4 times/day for at least 3 weeks.
For prevention of relapses of chronic herpes virus infection- 1 tablet/day. The recommended duration of the preventive course is determined individually and can reach 6 months.
When using the drug for treatment and prevention of immunodeficiency conditions, in complex therapy of bacterial infections- take 1 tablet/day.
If necessary, the drug can be combined with other antiviral and symptomatic means.
Possible allergic reactions and manifestations of increased individual sensitivity to the components of the drug.
No cases of overdose have been reported to date. In case of accidental overdose, dyspepsia may occur due to the excipients included in the drug.
Cases of incompatibility with others medicines has not been identified to date.
Pills.
Basic physical and chemical properties: tablets are flat-cylindrical in shape, scored and chamfered, from white to almost white in color. There is a line on one flat side and ANAFERON on the other flat side.
Homeopathic medicine.
The drug is used for the treatment and prevention of acute respiratory viral infections and influenza. When used prophylactically and therapeutically, it has an antiviral effect. Experimentally and clinically proven effectiveness against influenza viruses, parainfluenza, herpes simplex viruses types 1 and 2 (labial herpes, genital herpes), other herpes viruses (varicella, infectious mononucleosis), enteroviruses, tick-borne encephalitis virus, rotavirus, coronavirus, calicivirus, adenovirus , respiratory syncytial virus (RS virus). The drug reduces the concentration of the virus in the affected tissues, acts on the system of endogenous interferons and associated cytokines, induces the formation of endogenous “early” interferons (IFN α/β) and γ-interferon (γ-IFN). Has antimutagenic properties.
Prevention and treatment of acute respiratory viral infections (including influenza).
Complex therapy of infections caused by herpes viruses (infectious mononucleosis, chicken pox, labial herpes, genital herpes).
Complex therapy and prevention of relapses of chronic herpesvirus infection, including labial and genital herpes.
Complex therapy and prevention of other acute and chronic viral infections caused by tick-borne encephalitis virus, enterovirus, rotavirus, coronavirus, calicivirus.
Complex therapy of secondary immunodeficiency states of various etiologies, including prevention and treatment of complications of viral and bacterial infections.
Increased individual sensitivity to the components of the drug.
There are no cases of incompatibility with other drugs.
If necessary, the drug can be used in conjunction with other antiviral, antibacterial and symptomatic agents.
The drug contains lactose, and therefore it is not recommended for use in patients with congenital galactosemia, glucose malabsorption syndrome, or congenital lactase deficiency.
There are no data on the effectiveness and safety of the drug during pregnancy and lactation, so it should not be prescribed during these periods.
Does not affect reaction speed when driving vehicles or operating other mechanisms.
The drug is taken orally, 1 tablet 30 minutes before or 30 minutes after a meal. Keep the tablet in your mouth (preferably without chewing or swallowing) until completely dissolved.
ARVI, influenza, intestinal infections, herpesvirus infections, neuroinfections.
Treatment should begin as early as possible when the first signs of an acute viral infection appear according to the following scheme: for the first 2 hours the drug is taken every 30 minutes (5 doses), then during the first 24 hours - another 3 tablets at regular intervals (a total of 8 tablets during the first days). Starting from the 2nd day and thereafter, the drug is taken 1 tablet 3 times a day until complete recovery.
If there is no improvement on the third day of treatment for acute respiratory viral infections and influenza, you should consult a doctor.
For prevention, take 1 tablet once a day for 1-3 months (during the entire epidemic season).
Genital herpes. For acute manifestations of genital herpes, take at regular intervals according to the following scheme: 1-3 days - 1 tablet 8 times a day, then - 1 tablet 4 times a day for at least 3 weeks.
To prevent relapses of chronic herpesvirus infection - 1 tablet per day. The recommended duration of the preventive course is determined individually and can reach 6 months.
For the treatment and prevention of immunodeficiency conditions, take 1 tablet per day.
Do not use in children.
No cases of overdose have been reported. In case of accidental overdose, dyspeptic symptoms are possible due to the components included in the drug.
Allergic reactions are possible, including itching, rash, hives, skin flushing and swelling, and difficulty swallowing.
Do not use the medicine after the expiration date indicated on the package.
Store at a temperature not exceeding 25 °C.
Keep out of the reach of children.
20 tablets in a blister; 1 blister in a cardboard box.
Latin name: Anaferon
ATX code: L03/J05AX
Active ingredient: Antibodies
to human interferon gamma
Manufacturer: NPF MATERIA
MEDICA HOLDING LLC, Russia
Conditions for dispensing from a pharmacy: Over the counter
Price: from 180 to 230 rub.
“Anaferon” refers to immunomodulatory medicines. Presented in tablet form. Effective in fighting viruses.
“Anaferon” can be used for complex therapy and prevention of influenza, acute respiratory infections and other viral diseases. It is taken in cases of infection by the virus, when the disease is severe. As for the treatment of children, the child can be given “Anaferon for children”; there is also an analogue – “Aflubin”.
“Anaferon” adult, its active substance – antibodies to interferon gamma, are effective in preventing damage by herpes viruses.
It is recommended to take Anaferon tablets if you are infected with influenza, rotavirus, or tick-borne encephalitis. The drug is effective against enterovirus, coronavirus. Active substance The drug, antibodies to interferon gamma, is quite effective in the treatment of secondary immunodeficiency conditions. The drug is used to prevent and treat complications caused by viral and bacterial infections.
The main substance in 1 tablet of “Anaferon” is affinity-purified antibodies to human interferon gamma: a mixture of homeopathic dilutions C12, C30 and C200 – 3 mg.
Excipients are:
“Anaferon” for children has the same composition as for adults. The main difference is in the concentration of antibodies. The optimal concentration for adults and children has been identified based on numerous experiments and studies. Therefore, each form of the drug is more effective for the corresponding age category.
“Anaferon” is drunk when they want to prevent or cure a cold, if any. high temperature, and also against influenza. The antiviral effect of the drug begins to appear immediately after resorption. It reduces the concentration of viruses and increases the body's immune strength.
“Anaferon” for children can be used by children from one month to fourteen years to combat viral diseases.
The average price is from 200 to 230 rubles.
Anaferon is a flat-cylindrical tablet. They are white, sometimes with shades close to it. The manufacturer's name is printed on one side (divided by a notch). in Latin letters, on the other flat side you can read the name of the drug.
The package contains 20 tablets. Sold in a cardboard box, complete with instructions for use.
The tablet can be taken orally. Dosage: 1 tablet. in 30 min. after or before eating. The drug must be kept in the mouth, it must not be chewed or swallowed until it is absorbed.
The effectiveness of treatment depends on the time of start of use - the earlier the symptoms of the disease were noticed (the temperature rose, for example), the sooner you need to start taking it.
Should be taken every day according to the following schedule: the first 2-3 hours of tablets with an interval of 30 minutes. This is done before or after meals. After taking the first few days, 3 tablets. at equal intervals (8 tablets on the first day or two).
After taking, on the 2nd day “Anaferon” you should drink the dosage: 1 tablet. quantity – 3 times a day until recovery.
If no effect is observed on the third day of treatment, it is better to consult a doctor.
As a method of prevention, the drug should be taken in the following dosage: 1 tablet. quantity – once a day for several months.
For herpes disease and chickenpox, you should drink according to the following scheme: 1 tablet. quantity – 8 times a day for the first few days. Then reduce the dose to 4 tablets. quantity – per day (for 7 days).
To prevent infection by herpes viruses, you should drink “Anaferon” according to the following scheme: 1 tablet. once a day for a trimester or two.
It is forbidden to take it to a child; for these purposes you can give “Anaferon” for children (or “Aflubin”).
Average price from 180 to 210 rubles.
Tablets are flat, round. They are used for the same purposes as simple Anaferon, namely: to treat and have a preventive effect on viral diseases. They are white, sometimes with gray or yellow tint. They produce 20 tablets per package.
It is necessary to dissolve one tablet at a time (this method is recommended for prevention various diseases- 1 tablet 1 time per day). If the drug is prescribed to children aged 1 month to 3 years, then the medicine should first be diluted in a spoon with boiled water.
For acute respiratory viral infections, influenza and herpes - the dosage regimen is identical to the adult “Anaferon”
Some patients may experience sensitivity to some components of the drug. It is prohibited to use “Anaferon” against viruses during pregnancy and lactation. It is also prohibited for children under 1 month (they should be given “Anaferon for children”, instructions for use of which are presented above).
See the article to know how to safely and quickly get rid of a cough during pregnancy.
Anaferon tablets are fully compatible with other medications.
Alcohol and Anaferon are conditionally compatible. It should be remembered that alcohol reduces immunity, which can worsen the effect of the drug.
As a side negative reactions The body may experience allergies to the drug, such as itching, hives, swelling and redness of the skin, difficulty swallowing and some others. In such cases, you can use analogues (“Viferon”, “Kagocel”, “Amiksin”, “Ergoferon”).
There are no data on cases of overdose with Anaferon. If the recommended daily dose has been exceeded, then dyspeptic symptoms are possible, which can be caused by the components that are part of the drug.
The drug is valid for up to 3 years. Do not use if the expiration date indicated on the box has expired. Anaferon tablets should be stored out of the reach of children, at a temperature that does not exceed 25 °C.
“Anaferon” has analogues. They can perform in different dosage form: drops, tablets, suspension, suppositories. They are also effective against viruses. The most common among them:
Nearmedic plus, Russia
Price from 220 to 270 rub.
A drug with an antiviral effect. Available in tablet form. It can be used by both adults and children (from 3 years old).
Pros
Cons
Materia Medica, Russia
Price from 280 to 350 rub.
Ergoferon is best suited for the treatment of viral and colds, flu.
Pros
Cons
Bittner, Austria
Price from 250 to 350 rub.
Homeopathic remedy. The drug is presented in tablets and syrup form.
Pros
Cons
Feron, Russia
Price from 250 to 850 rub.
"Viferon" is available in the form of suppositories and ointments. "Viferon" improves human immunity. They also recommend Viferon to those who not only suffer from colds and flu, but also hepatitis, plasmosis, herpes, and chickenpox.
Pros
Cons
Pharmstandard, Russia
Price from 550 to 700 rub.
Available in tablet form orange color, which are covered with a special shell. “Amiksin” is indicated for viral hepatitis A, B, C.
Pros
Cons
Anaferon: instructions for use and reviews
Latin name: Anaferon
ATX code: J05AX, L03
Active ingredient: affinity purified antibodies to human gamma-interferon
Manufacturer: NPF Materia Medica Holding LLC (Russia)
Updating the description and photo: 26.08.2019
Anaferon is an antiviral immunomodulatory agent that helps increase the number of antibodies, activate the cellular and humoral components of immunity and the formation of interferon.
They produce Anaferon for adults and Anaferon for children, both drugs are produced in the form of tablets for sublingual use (20 pieces in blister packs, 1 pack in a cardboard box).
The drug contains affinity purified antibodies to human interferon gamma – 3 mg.
When using Anaferon as a preventive and remedy it exhibits antiviral and immunomodulatory effects. During various experiments and clinical trials it was found that the drug is effective against respiratory syncytial virus (RS virus), influenza and parainfluenza viruses, adenovirus, herpes simplex viruses types 1 and 2 (genital herpes, labial herpes), other herpes viruses (infectious mononucleosis, chickenpox) , calicivirus, enteroviruses, coronavirus, rotavirus, tick-borne encephalitis virus. The drug reduces the virus content in affected tissues, activates the formation of interferon gamma (IFNγ) and endogenous early interferons (IFNα/β).
The drug is a stimulator of cellular and humoral immune responses, induces the synthesis of antibodies [including secretory immunoglobulin A (IgA)], enhances the functions of T-helpers (Tx) and T-effectors, normalizes their ratio. Anaferon also increases the functional reserve of Th1 and other cells responsible for the immune response, is an inducer of a mixed Th1 and Th2 type of immune response, enhances the production of Th1 (IL-2, IFNγ) and Th2 (IL-4, 10) cytokines, modulates ( leads to standard values) balance of Th1/Th2 activities. The drug increases the functional activity of natural killer cells (NK cells) and phagocytes. It is characterized by antimutagenic properties.
Modern physical and chemical types of analysis (chromatography-mass spectrometry, high-performance liquid chromatography, gas-liquid chromatography) have a sensitivity that does not allow an accurate assessment of the concentrations of Anaferon’s active components in organs, tissues and biological fluids. In this regard, studying the pharmacokinetic parameters of the drug is not possible.
Anaferon is indicated for both children and adults in the following cases:
According to the instructions, Anaferon is contraindicated if you are intolerant to its components.
During pregnancy and lactation, the drug is prescribed with caution.
Anaferon tablets for adults are prescribed 1 pc. from 3 to 6 times a day, if there are signs of improvement, you can take the drug once a day for 8-10 days.
Anaferon for children is prescribed starting from one month old child.
At respiratory diseases When the first symptoms appear, the drug is used according to the following scheme: in the first 2 hours, every 30 minutes, a tablet and 3 more tablets during the first 24 hours. Then you should take 1 tablet 3 times a day until complete recovery.
To prevent bacterial complications, Anaferon tablets are prescribed, 1 pc. 1 time per day on an empty stomach for 8-12 days.
When taking the drug, do not swallow the tablet until it is completely dissolved, and for children from one month to 3 years old, the drug is dissolved in a tablespoon of boiled water.
Side effects are rare. In some cases, the drug may cause increased sensitivity to the components included in its composition.
There are currently no reports of overdose cases. If the drug is accidentally taken in high doses, dyspeptic symptoms associated with the fillers included in its composition may be observed.
Since the product contains lactose, the use of the drug is not recommended for patients with glucose malabsorption syndrome, congenital galactosemia or lactase deficiency.
The safety of administering Anaferon to pregnant and lactating women has not yet been proven. If treatment with the drug is necessary, carefully weigh possible risks for the fetus or child and the potential benefit of treatment for the mother.
Children over 1 month and adolescents under 18 years of age are advised to use Anaferon for children according to indications in compliance with the dosage regimen prescribed by the doctor.
Anaferon analogues are: Immunal, Echinacea compositum, Tsitovir-3, Cycloferon, Galavit, Amiksin, Polyoxidonium, Derinat, Erbisol, etc.
Anaferon should be stored in a dry and dark place, out of reach of children, at a temperature not exceeding 25 °C.
Shelf life – 3 years.
Instructions for medical use
medicine
ANAFERON
Trade name of the drug
Anaferon
International nonproprietary name
Dosage form
Lozenges
Compound
One tablet contains
active substance: Antibodies to human interferon gamma, affinity purified - 0.003 g*;
excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate.
* applied to lactose monohydrate in the form of a water-alcohol mixture containing no more than 10 -15 ng/g of the active form of the active substance.
Description
Tablets are flat-cylindrical in shape, scored and chamfered, from white to almost white in color. On the flat side with a notch there is the inscription MATERIA MEDICA, on the other flat side there is the inscription ANAFERON.
Pharmacotherapeutic group
Other antiviral drugs
ATX codes J05AX.
Pharmacological properties
Pharmacokinetics
The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the drug Anaferon.
Pharmacodynamics
When used prophylactically and therapeutically, the drug has an immunomodulatory and antiviral effect. Experimental and clinical efficacy has been established against influenza viruses, parainfluenza, herpes simplex viruses types 1 and 2 (labial herpes, genital herpes), other herpes viruses (varicella, infectious mononucleosis), enteroviruses, tick-borne encephalitis virus, rotavirus, coronavirus, calicivirus , adenovirus, respiratory syncytial (PC virus). The drug reduces the concentration of the virus in the affected tissues, affects the system of endogenous interferons and associated cytokines, induces the formation of endogenous “early” interferons (IFN a/β) and interferon gamma (IFN γ).
Stimulates the humoral and cellular immune response. Increases the production of antibodies (including secretory IgA), activates the functions of T-effectors, T-helpers (Tx), normalizes their ratio. Increases the functional reserve of Tx and other cells involved in the immune response. It is an inducer of a mixed Txl and Th2 type of immune response: it increases the production of Txl (IFN γ, IL-2) and Th2 (IL-4, 10) cytokines, normalizes (modulates) the balance of Th1/Th2 activities. Increases the functional activity of phagocytes and natural killer cells (EK cells). Has antimutagenic properties.
Indications for use
Prevention and treatment of acute respiratory viral infections (including influenza)
Complex therapy of infections caused by herpes viruses (infectious mononucleosis, chicken pox, labial herpes, genital herpes)
Complex therapy and prevention of relapses of chronic herpesvirus infection, including labial and genital herpes
Complex therapy and prevention of other acute and chronic viral infections caused by tick-borne encephalitis virus, enterovirus, rotavirus, coronavirus, calicivirus
Use as part of complex therapy of bacterial infections
Complex therapy of secondary immunodeficiency conditions of various etiologies, including prevention and treatment of complications of viral and bacterial infections
Directions for use and doses
Inside. For one dose - 1 tablet (keep in mouth until completely dissolved - not during meals).
ARVI, influenza, intestinal infections, herpesvirus infections, neuroinfections. Treatment should begin as early as possible - when the first signs of an acute viral infection appear according to the following scheme: in the first 2 hours the drug is taken every 30 minutes, then during the first 24 hours three more doses are taken at equal intervals. From the second day onwards, take 1 tablet 3 times a day until complete recovery.
If there is no improvement, on the third day of treatment with the drug for acute respiratory viral infections and influenza, you should consult a doctor.
During the epidemic season, for prophylactic purposes, the drug is taken daily once a day for 1-3 months.
Genital herpes. For acute manifestations of genital herpes, the drug is taken at regular intervals according to the following scheme: days 1-3 - 1 tablet 8 times a day, then 1 tablet 4 times a day for at least 3 weeks.
To prevent relapses of chronic herpesvirus infection - 1 tablet per day. The recommended duration of the preventive course is determined individually and can reach 6 months.
When using the drug for the treatment and prevention of immunodeficiency conditions, in complex therapy of bacterial infections, take 1 tablet per day.
If necessary, the drug can be combined with other antiviral and symptomatic agents.
Side effects
When using the drug according to the indicated indications and in the indicated dosages side effects not identified.
Manifestations of increased individual sensitivity to the components of the drug are possible.
Contraindications
Increased individual sensitivity to the components of the drug
Children's and adolescence up to 18 years old
Drug interactions
No cases of incompatibility with other drugs have been identified to date.
If necessary, the drug can be combined with other antiviral, antibacterial and symptomatic agents.
Special instructions
The drug contains lactose monohydrate, and therefore is not recommended for use in patients with congenital galactosemia, glucose malabsorption syndrome, or congenital lactase deficiency.
Pregnancy and lactation
The safety of Anaferon in pregnant women and during lactation has not been studied. If it is necessary to take the drug, the risk/benefit ratio should be taken into account.
Features of the influence on the ability to manage vehicle or other potentially dangerous mechanisms
