photo instructions for use of Erespal 80 mg tablets part 1
International nonproprietary or generic name: Fenspiride
Dosage form: film-coated tablets.
Compound: 1 film-coated tablet contains active substance: fenspiride hydrochloride - 80 mg.
Excipients: calcium hydrogen phosphate 104.5 mg; hypromellose 100 mg, povidone 12.80 mg; colloidal silicon dioxide anhydrous 0.50 mg; magnesium stearate 2.20 mg;
Titanium dioxide shell 0.841 mg; glycerol 0.263 mg; hypromellose 4.370 mg; macrogol 6000 0.263 mg, magnesium stearate 0.263 mg.
Description
Photo of instructions for use of Erespal 80 mg tablets, part 2
Round, biconvex, film-coated tablets, white.
Pharmacotherapeutic group Anti-inflammatory, antibronchoconstrictor agent.
ATX code: R03DX03
Photo of Eerspal 80 mg tablets, they are film-coated and have white and round shape, packed in a blister, the name of the tablets (erespal) is written on the blister, active substance(Fenspiride), expiration date indicated.
I suggest you familiarize yourself with a cheaper analogue Erespal, it is not inferior to it in effectiveness, the active substance is the same (fenspiride), but it costs much cheaper!!!
Pharmacodynamics
The anti-inflammatory and antibronchoconstrictor activity of fenspiride is due to a decrease in the production of a number of biologically active substances (cytokines, especially tumor necrosis factor a (TNF-a), derivatives arachidonic acid, free radicals), playing an important role in the development of inflammation and bronchospasm.
The inhibition of arachidonic acid metabolism by fenspiride is potentiated by its H2-antihistamine effect, because histamine stimulates the metabolism of arachidonic acid with the formation of prostaglandins and leukotrienes. Fenspiride blocks α-adrenergic receptors, the stimulation of which is accompanied by an increase in the secretion of the bronchial glands. Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of proinflammatory factors, the development of inflammation and bronchial obstruction.
Fenspiride also has an antispasmodic effect.
Pharmacokinetics
Cmax after oral administration is reached within 6 hours. T 1/2 -12 hours. It is excreted primarily by the kidneys.
Diseases of the upper and lower respiratory tract:
Otitis and sinusitis of various etiologies.
Increased sensitivity to active substance and/or any of the components of the drug. Childhood up to 18 years of age (Erespal* syrup should be used to treat children and adolescents under 18 years of age).
Taking the drug during pregnancy is not recommended.
Fenspiride therapy is not a reason to terminate an ongoing pregnancy. There are no clinical data on the fetotoxic effect of fenspiride or its ability to cause malformations when taken during pregnancy.
Erespal* should not be used during breastfeeding due to the lack of data on the penetration of fenspiride into breast milk.
Adults: 1 tablet 2-3 times a day. Maximum daily dose is 240 mg. The duration of treatment is determined by the doctor.
INFORM YOUR DOCTOR ABOUT ANY ADVERSE REACTIONS AND SENSATIONS YOU EXPERIENCE, INCLUDING THOSE NOT MENTIONED IN THIS INSTRUCTION, AS WELL AS CHANGES IN LABORATORY VALUES DURING THE THERAPY.
Frequency adverse reactions that may occur during therapy are given in the following gradation: very often (>1/10); often (>1/100,<1/10); нечасто (>1/1000, <1/100); редко (>1/10000, <1/1000); очень редко (<1/10000) и неустановленной частоты (частота не может быть подсчитана по доступным данным).
From the cardiovascular system:
Rarely: moderate tachycardia, the severity of which decreases with decreasing dose of the drug.
From the digestive system:
Often gastrointestinal disorders, nausea, epigastric pain. Unspecified frequency: diarrhea, vomiting.
From the central nervous system: Rarely: drowsiness
Unknown frequency: dizziness.
Common disorders and symptoms: Unspecified frequency: increased fatigue. For the skin and subcutaneous fat:
Rarely: erythema, rash, urticaria, angioedema, fixed erythema pigmentosa.
Unspecified frequency: skin itching.
In case of an overdose of the drug (cases of overdose have been reported when taking the drug at a dose of more than 2320 mg), you should immediately seek medical help. Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia. Treatment: gastric lavage, electrocardiogram (ECG) monitoring. Maintaining vital body functions.
No special studies have been conducted on the interaction of fenspiride with other drugs.
Due to the possible enhancement of the sedative effect when taking histamine H2-receptor blockers, the use of Erespal* in combination with drugs that have a sedative effect or with alcohol is not recommended.
Erespal* syrup should be used to treat children and adolescents under 18 years of age. No studies have been conducted to study the effect of Erespal* on the ability to drive vehicles and operate machinery. Patients should be aware of the possible development of drowsiness while taking the drug Erespal*, especially at the beginning of therapy or when combined with alcohol intake, and should be careful when driving vehicles and when performing work that requires a high speed of psychomotor reactions.
Film-coated tablets, 80 mg.
15 tablets per blister (PVC/Al). 2 blisters with instructions for medical use per cardboard pack.
The active ingredient of Erespal is fenspiride. The product belongs to the category of anti-inflammatory, antibronchoconstrictor medications.
Intended for symptomatic treatment of the respiratory tract, ENT organs, blocking inflammatory processes and eliminating allergic reactions due to diseases.
In this article we will look at why doctors prescribe the drug Erespal, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Erespal, leave your feedback in the comments.
Clinical and pharmacological group: a drug with anti-inflammatory and antibronchoconstrictor activity.
Excipients: flavoring composition with hints of honey smell* 0.500 g, licorice root extract 0.200 g, vanilla tincture** 0.400 g, glycerol 22.5 g, methyl parahydroxybenzoate 0.09 g, propyl parahydroxybenzoate 0.035 g; saccharin 0.045 g, sucrose 60.0 g, potassium sorbate 0.19 g; purified water up to 100 ml.
The drug is primarily prescribed for the treatment of the upper and lower respiratory tract. Erespal helps in such cases:
Fenspiride counteracts bronchoconstriction and has an anti-inflammatory effect in the respiratory tract. This action is the result of the interaction of various interrelated mechanisms:
Erespal syrup should be shaken before use.
Dosage for Erespal tablets:
The duration of treatment is determined by the doctor.
The drug should not be used in the following cases:
When using the drug, the following adverse reactions may develop:
You may be sensitive to the dye contained in the product.
If you take a dose of Erespal more than recommended, symptoms of overdose may appear: tachycardia, vomiting, nausea, agitation or, conversely, lethargy and drowsiness. Treatment in this case is symptomatic - gastric lavage, administration of absorbents, and drinking plenty of fluids.
There are no or limited data on the use of Erespal in pregnant women. The use of the drug during pregnancy is not recommended. Erespal should not be used during breastfeeding due to the lack of data on the penetration of fenspiride into breast milk.
Analogs of Erespal syrup and tablets in terms of effects on the human body are Stoptussin, Fenspiride, Ascoril, Fluditek, Lazolvan, Ambrobene.
The average price of ERESPAL syrup in pharmacies (Moscow) is 225 rubles. Tablets cost 325 rubles.
Store at a temperature not exceeding 30°C. Erespal vials can be stored open throughout the treatment. After completion of the treatment period, it is not recommended to use an open bottle.
The drug is available with a prescription.
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Sore throat, hoarseness. For the treatment of various diseases of the ENT organs of an infectious, allergic and inflammatory nature, as well as respiratory diseases, the most effective remedy is Erespal.
Erespal is an antihistamine based on the active ingredient fenspiride. The drug has bronchodilator and antiexudative effects. The active substance, entering the body, prevents the development of bronchospasm and reduces the release of exudate. The drug has a myotropic antispasmodic effect.
Fenspiride slows down the metabolism of arachidonic acid, which provides an anti-inflammatory effect. The active substance also blocks histamine receptors and reduces the production of substances such as serotonin, bradykinin, and histamine.
The active substance fenspiride is actively absorbed into the gastrointestinal tract. The highest concentration of fenspiride is achieved 6 hours after taking the Erespal tablet and 2.5 hours after consuming the syrup.
It is excreted from the body mainly by the kidneys, but can also be excreted by the intestines.
The drug is available in the form and. One Erespal tablet contains 80 mg of active substance.
Other elements included in the medicinal product:
The amount of active ingredient in the syrup is 2 mg per 1 ml. Amount of syrup 150 ml. In addition to fenspiride, the syrup includes: saccharin, potassium sorbate, sucrose, glycerol, methyl parahydroxybent, licorice extract, etc.The drug is dispensed according to a doctor's prescription.
The drug Erespal is used during colds to reduce the severity of respiratory symptoms, as well as in cases of respiratory rhythm disturbance due to whooping cough and measles.
An anti-inflammatory drug is prescribed for the treatment of:
The drug is used to treat diseases of the ENT organs in acute or chronic form.
The drug is used to treat infectious diseases of the respiratory tract, which are accompanied by cough.
In this case, the treatment includes the use of the anti-inflammatory drug Erepal.The drug is used for the complex treatment of acute and chronic bronchial asthma.
The drug in this form can be used from the age of 14. Adults and children are prescribed 80 mg of the drug 2 times a day. If syrup is used, then 45-90 ml of medicine (3-6 tablespoons) is prescribed. The doctor prescribes the dosage of the drug taking into account the severity and form of the disease. It is possible to increase the daily dose to 240 mg. This dose is divided into 2-3 doses.
For children under 14 years of age, the drug is prescribed only in the form of syrup. If the child weighs up to 10 kg, then you should take 1-2 teaspoons 2 times a day. For children weighing more than 10 kg, the dosage is increased to a tablespoon (1-2 large spoons in the morning and evening).
You should know that a tablespoon of syrup contains 30 mg of fenspiride and about 9 g of sucrose, and a teaspoon contains 10 mg of active ingredient and no more than 3 g of sucrose.
A prerequisite is to take the medicine before meals.
Simultaneous use of the drug with acetylsalicylic acid is not recommended, as allergic reactions and bronchospasm may occur. This should be taken into account when used with various anti-inflammatory non-steroidal drugs.
More information on how to treat a cold can be found in the video.
If after using the drug the indicated symptoms are observed after some time, then you should stop taking Erespal.
Taking into account the symptoms, symptomatic therapy and gastric lavage are indicated.
If tachycardia occurs while using Erespal, you should undergo an electrocardiogram.
If you cannot take Erespal if you are hypersensitive to the components, your doctor may prescribe other medications.
Analogues of the drug Erespal include:
These drugs have similar pharmacological effects and indications for use, but prices may vary. It is not recommended to replace Erespal medication on your own. If necessary, the doctor will prescribe another drug.
You must comply with the storage conditions not only for Erespal, but also for all other medications. If you neglect the rules specified in the instructions, you can turn it into poison.
Erespal is recommended to be stored at a temperature of no more than 25 degrees. It is prohibited to store it in an open place. The storage location should be chosen so that children do not have access to it.It is also not recommended that the drug be exposed to sunlight.
The shelf life of the drug is 3 years, after this period it is prohibited to use the drug.
The drug should not be thrown away; it must be saved in order to clarify the dosage of use if necessary.
Erespal (INN fenspiride) is an anti-inflammatory and bronchodilator drug from Les Laboratoires Servier (France), used to treat diseases of the upper and lower respiratory tract. Acute respiratory diseases (ARI) affect millions of people of any age and gender every year. The most effective way to treat infectious and inflammatory diseases of the respiratory tract is etiotropic therapy, which involves influencing not the symptoms, but directly the cause of the disease, i.e. on its pathogen. However, in most cases this is not possible due to the lack of objective information about the pathogen, and therefore the principle of influencing the pathogenetic mechanisms of the disease comes to the fore. Whatever the etiology of acute respiratory infections - bacterial, viral, toxic, allergic - the common denominator in all these cases is the inflammatory process. Therefore, anti-inflammatory drugs are chosen as first-line drugs for patients of this profile. Inflammation of the mucous membrane of the upper and lower parts of the respiratory tract is accompanied by abundant mucus formation, swelling and proliferation of the mucous membrane, and narrowing of the lumen of the bronchi. The use of symptomatic remedies in such a situation seems to be ineffective. Considering that at the base of this pathogenetic “pyramid” is inflammation in any case, the optimal choice seems to be a drug that would not only promote the removal of the damaging agent, but also reduce the severity of the inflammatory reaction by localizing its focus and inhibiting the synthesis of inflammatory mediators that act as catalysts pathological process.
Erespal, which has an affinity for the morphological parts of the respiratory system, successfully copes with this task. This drug has a powerful anti-inflammatory effect comparable to that of glucocorticosteroids, but, unlike the latter, it does not exhibit systemic adverse reactions. Erespal blocks the action of phospholipase A2, acting as an inhibitor of the arachidonic acid cycle, which leads to a decrease in the concentration of inflammatory mediators - prostaglandins, leukotrienes and thromboxanes, and therefore relieves swelling, suppresses excess mucus secretion, and eliminates spastic phenomena. Erespal also acts as a histamine antagonist and alpha-1 adrenergic blocker, providing an antihistamine effect, which consists of diluting sputum and facilitating its evacuation from the respiratory tract. In addition to this, the drug locally reduces the excitability of the nervous system, thereby exhibiting an antispasmodic effect. In other words, Erespal negatively affects all the main parts of the inflammatory process. The drug is available in the form of tablets and syrup. It has a generally favorable safety profile and is well tolerated. Its mild sedative effect (antihistamine component) should be taken into account when performing work that requires increased psychomotor reactivity.
The anti-inflammatory and anti-bronchoconstrictor activity of fenspiride is due to a decrease in the production of a number of biologically active substances (cytokines (especially TNF-α), arachidonic acid derivatives, free radicals), which play an important role in the development of inflammation and bronchospasm.
Inhibition of arachidonic acid metabolism by fenspiride is potentiated by blockade of histamine H1 receptors, because histamine stimulates the metabolism of arachidonic acid with the formation of prostaglandins and leukotrienes. Fenspiride blocks α-adrenergic receptors, the stimulation of which is accompanied by an increase in the secretion of the bronchial glands. Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of proinflammatory factors, the development of inflammation and bronchial obstruction.
Fenspiride also has an antispasmodic effect.
Suction
After oral administration, Cmax is reached within 6 hours.
Removal
T 1/2 - 12 hours. Excreted mainly by the kidneys.
White film-coated tablets, round, biconvex.
Excipients: calcium hydrogen phosphate - 104.5 mg, hypromellose - 100 mg, povidone K30 - 12.8 mg, colloidal anhydrous silicon dioxide - 0.5 mg, magnesium stearate - 2.2 mg.
Shell composition: titanium dioxide - 0.841 mg, glycerol - 0.263 mg, hypromellose - 4.37 mg, macrogol 6000 - 0.263 mg, magnesium stearate - 0.263 mg.
15 pcs. - blisters (2) - cardboard packs.
For adults, the drug is prescribed 80 mg (1 tablet) 2-3 times a day.
The maximum daily dose is 240 mg. The duration of treatment is determined by the doctor.
In case of an overdose of the drug (cases of overdose have been reported when taking the drug at a dose of more than 2320 mg), the patient should immediately seek medical help.
Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia.
Treatment: gastric lavage, ECG monitoring, maintaining vital body functions.
No special studies have been conducted on the interaction of fenspiride with other drugs.
Due to the possible sedative effect when taking histamine H1 receptor blockers, the use of Erespal ® in combination with drugs that have a sedative effect or with alcohol is not recommended.
The most common adverse reactions to the drug Erespal ® are observed in the digestive system.
The frequency of adverse reactions that may occur during therapy is given in the following gradation: very often (>1/10); often (>1/100,<1/10); нечасто (>1/1000, <1/100); редко (>1/10 000, <1/1000); очень редко (<1/10 000); неустановленной частоты (частота не может быть подсчитана по доступным данным).
From the cardiovascular system: rarely - moderate tachycardia, the severity of which decreases with decreasing dose of the drug; unknown frequency* - a feeling of palpitations and a decrease in blood pressure, possibly associated with tachycardia.
From the digestive system: often - gastrointestinal disorders, nausea, epigastric pain; unknown frequency* - diarrhea, vomiting.
From the side of the central nervous system: rarely - drowsiness; unknown frequency* - dizziness.
From the skin and subcutaneous fat: rarely - erythema, rash, urticaria, angioedema, fixed erythema pigmentosa; unknown frequency* - skin itching, toxic epidermal necrolysis, Stevens-Johnson syndrome.
General disorders: unknown frequency* - asthenia, increased fatigue.
* Data from post-registration use.
The patient should be informed of the need to inform the doctor about any, incl. undesirable reactions not mentioned above, as well as changes in laboratory parameters during therapy with Erespal ® .
Diseases of the upper and lower respiratory tract:
Otitis and sinusitis of various etiologies.
There are no or limited data on the use of Erespal ® in pregnant women. The use of the drug during pregnancy is not recommended.
Fenspiride therapy is not a reason to terminate an ongoing pregnancy.
Erespal ® should not be used during breastfeeding due to the lack of data on the penetration of fenspiride into breast milk.
Erespal ® syrup should be used to treat children and adolescents under 18 years of age.
Impact on the ability to drive vehicles and operate machinery
No studies have been conducted to study the effect of Erespal ® on the ability to drive vehicles and operate machinery. Patients should be aware of the possible development of drowsiness while taking the drug Erespal ®, especially at the beginning of therapy or when combined with alcohol intake, and should be careful when driving vehicles and when performing work that requires a high speed of psychomotor reactions.
Many people are interested in the question of what cough Erespal helps with. The use of the drug for severe coughing attacks helps restore breathing and alleviate the patient’s condition. The medication has several release forms: they are different for adults and children. The manufacturing company (Les Laboratoires Servier) is located in France.
Erespal is an effective bronchodilator, the use of which for medicinal purposes should be carried out according to the instructions. The presence of contraindications prescribed in the annotation makes it impossible to use the drug. Prices may vary depending on the location of sale.
The concentration of the active substance - fenspiride hydrochloride - may vary depending on the release form. The drug is marketed in tablet and syrup form. Cough tablets are round, milky, biconvex, coated with an enteric film. They contain 80 mg of the active ingredient and a number of additional substances:
Children's medicine is a slightly caramelized (consistency) suspension of brownish-yellow color. The concentration of the main component in Erespal syrup does not exceed 2 mg per 1 ml of product. Auxiliary components provided by the manufacturer:
Anti-inflammatory cough syrup is sold in dark glass bottles, hermetically sealed with an aluminum stopper (150 ml). Pills - in blisters of 10-30 pcs. All forms of release are sold in cardboard boxes, inside of which there is an annotation.
Erespal in the form of syrupErespal, like most cough medicines, has anti-inflammatory, mucolytic, antimicrobial and antispasmodic properties. When the active substance enters the body, it quickly reaches the site of inflammation and reduces the productivity of cytokines and free radicals involved in the inflammatory process.
Syrup and tablets help against chronic cough (in smokers). With regular use, the severity of inflammation decreases and swelling subsides. Thanks to its antihistamine properties, the medication eliminates discomfort in the throat (stingling, burning, pain). A decrease in muscle tone ensures expansion of the lumen of the bronchopulmonary tract.
The main indications for use are relief of the severity of the clinical syndrome. In addition to coughing, the medication helps get rid of a number of pathologies.
Before answering the question for which cough Erespal can be taken, it is necessary to determine the type of clinical syndrome. There are several main types of cough: dry cough and wet cough, accompanied by sputum production. The drug can be used in both cases. With a dry cough, Erespal eliminates irritation; with a wet cough, it thins the mucus in the bronchi.
Erespal for dry cough helps reduce attacks of unproductive cough. The medication gradually transforms a dry cough into a wet one. Another function of the medicine for barking cough in children and adults is protective. It protects the mucous membrane from ruptures and damage. Children's dry cough syrup dilates the bronchi, eliminates bronchospasms, soreness and a feeling of dryness in the throat.
Erespal with a wet cough eliminates swelling of the bronchi and stops the spread of the inflammatory process to healthy areas of the respiratory system. The smooth muscles relax - against the background of this, the patient experiences shortness of breath and painful phenomena that accompany coughing attacks. Long-term use of the drug for wet cough helps prevent relapse.
Taking medication for dry and wet cough in a child The main indications for use are diseases of the internal respiratory organs. The instructions for use describe the following pathologies:
The medicine for children is taken when diagnosing the following diseases:
The medication is approved for use for sinusitis and otitis of various etiologies.
Use of Erespal for otitis media The drug has contraindications, which depend on the form of release. Restrictions for taking the tablet form:
For the medicine:
Any ailments that accompany taking the medication are classified as side effects. They occur against the background of an incorrectly selected dosage regimen. Most often, side effects are observed in internal organs and the central nervous system.
From the digestive system, ailments are expressed in the form of pain in the epigastric region, stool disturbances (diarrhea) and vomiting. From the cardiovascular system, rapid heartbeat and surges in blood pressure are observed.
Dizziness, headaches and sleep disturbances are considered side effects from the nervous system. Most often, children experience all kinds of allergic reactions in the form of facial flushing, erythema, and urticaria. Skin itching and burning sensation are the most common manifestations of allergies. With prolonged use of the syruped form, the child quickly gets tired.
Dizziness from taking Erespal Before using the medicine, you must carefully study the instructions for use of Erespal, included inside the box. The medicine is prescribed by the doctor based on the results of tests previously taken by the patient. The course of application and dosage regimen is determined individually depending on the age of the patient.
The daily dosage of the drug for adult patients should not exceed 240 mg, which is equivalent to 3 tablets. The drug must be taken at the same time, 15 minutes after eating. The tablets are drunk whole, without breaking or chewing. You can take the medicine only with boiled water - carbonated drinks, energy drinks, tea and coffee cannot be used for these purposes. The period of application is no more than 10 days.
The therapeutic norm of the mixture for children is determined based on the body weight and age of the child. For convenience, the medicine is poured into a bottle (for children under 3–4 years old). Before opening, it is recommended to shake the bottle vigorously for 20–30 seconds - this will dissolve the sediment.
It is recommended to give 4 mg/1 kg to children under 4 years of age - if the baby weighs less than 10 kg, then he should be given 1 teaspoon of syrup once before or during meals. If the child's weight exceeds 10 kg, he is given 1 tbsp. l. emulsions once. Adolescent children (12 years and older) are given 2 tbsp once. l. You can take no more than 5–6 tablespoons of the product per day. The course of treatment is 7–10 days.
The use of Erespal for medicinal purposes during pregnancy is possible for health reasons in the absence of a threat to the health of the mother and fetus. The appointment is carried out under the supervision of a specialist. The recommended dosage regimen is to take half doses (no more than 120 mg/day). The course of treatment must be reduced by 2 times. If ailments occur in the digestive tract or nervous system, the use of the medication must be stopped immediately.
Features of taking Erespal during pregnancy A bronchodilator is often combined with antiviral, immunomodulatory, and mucolytic agents. With the simultaneous use of Erespal and antihistamines, the sedative effect of the bronchodilator may be enhanced.
Experts recommend taking vitamins simultaneously with the medication. Against the background of infectious diseases, the body’s defense reactions decrease, so treatment with an anti-inflammatory drug is accompanied by taking vitamin-mineral complexes (Supradin Kids, Kaltsinova, Pikovit).
The medicine is in the middle price category; prices for the medicine and tablets vary depending on the region and place of sale. The cost of the tablet form is from 300 rubles, the price of syrup is from 230 rubles. Both dosage forms can be ordered on the manufacturer's official website - in this case the price will be higher than in pharmacies. Shipping costs will be included.
Erespal syrup and tablets have several structural analogues that have therapeutic properties similar to the original. Analogues of the drug for adults:
The closest analogue of children's medicine is Lazolvan syrup. The active ingredient is ambroxol. The mucolytic has a pleasant fruity aroma and taste; it can be used for bronchitis, pharyngitis, tracheitis and laryngitis in children.
When asked by patients which is better - Erespal or Askoril (, Lazolvan, etc.), there is no clear answer. Drugs act differently on the body due to its individual characteristics.
