Gliatilin is a nootropic drug that affects the central nervous system. Necessary for patients after brain injuries, in case of disorders of cerebral microcirculation, changes in behavior, emotional incontinence.
This is a neuroprotective drug. Contains choline alphoscerate. In the human body, the substance is divided into two components. The drug has a beneficial effect on the elasticity of membranes nerve cells. Receptor function is also affected.
It has a corrective effect on some factors of presenile psychoorganic syndrome. The drug improves cognitive abilities such as memory, thinking and attention in people who suffer from mild form dementia.
After taking it, people's mood improves, their emotional stability improves, and their thinking is activated. in full. The remedy can eliminate irritability, aggression and indifference.
Gliatilin is not an antibiotic, but it can be taken together with this group of drugs. Take the product regardless of food consumption. The duration of treatment can reach six months. Dispensed in pharmacies with a doctor's prescription.
Prescribed to women in critical days, and sometimes the reception is even useful, as it thins the blood. Use by HIV-infected patients is not prohibited, but in this case the dosage will need to be adjusted.
Does not affect the patient's ability to exercise dangerous species activities, including driving. You should not drink alcohol while taking the drug. There is no effect on blood pressure.
Gliatilin is available in the form of 400 mg capsules, injections and oral solution. The package may contain 14 capsules, 3 injection ampoules or 10 oral vials.
The composition includes glycerin and purified water.
ITALFARMACO (Italy)
Indicated for:
Gliatilin is contraindicated for use in:
May appear after administration allergic reactions and nausea.
Gliatilin has a beneficial effect on the entire body as a whole. Patients note an improvement in their condition. After taking it, your mood improves and a feeling of lightness appears. Most of the patients managed to strengthen their memory, get rid of aggression and anxiety. Getting better metabolic process, resistance to oxygen starvation increases.
Harm to the body is caused in case of uncontrolled use of the drug. It is forbidden to independently adjust dosages.
Gliatilin capsules are intended for oral use. It is recommended to take before eating. Take the pills with a small amount of liquid. Do not bite or crush the pellets. Swallow whole.
For cerebrovascular insufficiency and changes in behavior, take 400 mg three times in 24 hours. The duration of treatment is from 3 months to six months.
Gliatilin in children with mental, motor or mental retardation speech development injections into the muscle are prescribed. The course of therapy lasts up to two weeks. Capsules are taken for up to 12 weeks. The effectiveness of using injections is much higher.
With developmental delay or after birth trauma injected into the muscle. Children under one year old take from 250 to 500 mg. From one to three years, the dosage increases to 750 ml. Children over 3 years old should take 1000 mg. Use once every 24 hours. Course duration is up to 12 days.
In case of brain injuries, 1000 mg is injected into a muscle or vein per 24 hours. The course lasts a week. After this period, they begin to take capsules.
Capsules for developmental delay are prescribed to children under one year of age, one tablet three times in 24 hours. Therapy can last up to three months.
For brain injuries, one tablet is prescribed twice in 24 hours. Duration of treatment is up to two months.
If it is difficult for a child to swallow capsules, it is necessary to pierce the capsule with a clean needle from a syringe and draw out the contents. Place the composition into the child's mouth.
Elderly patients will not need to adjust their dosage. Pregnant women and nursing mothers should not take the medicine.
Substitutes for Gliatilin are:
Latin name: Gliatilin
ATX code: N07A X02
Active ingredient: choline alfoscerate
Manufacturer: Italfarmaco (Italy)
Release from the pharmacy: by prescription
Storage conditions: at temperatures below 25°C
Best before date: caps. – 3 years old, d/in. – 5 l.
Gliatilin is a nootropic and neuroprotective drug for improving brain activity. Accelerates neurotransmission, has a beneficial effect on the plasticity of nerve cell membranes, and improves metabolic reactions in the brain. Can be used to relieve acute conditions and during rehabilitation.
Gliatilin is indicated for therapy and prevention for:
Gliatilin capsules
Soft yellow ellipsoidal gelatin capsules. The body is not translucent. The filling is a viscous uncolored solution. Capsules are packaged in blisters of 14 pieces. In a cardboard package - 1 plate, annotation.
Gliatilin injections
Transparent liquid, colorless and odorless. The medicine is intended for intravenous and intramuscular use. Packaged in ampoules of 4 ml, placed in cell packaging. There are 3 ampoules in a cardboard box, a description of the injections.
Gliatilin solution
Average price: 590 rub.
The drug for oral administration is an uncolored, translucent liquid with an orange aroma. Packaged in dark glass bottles of 7 ml. A cardboard pack contains 1 container and a manual.
Currently, this dosage form of Gliatilin is not registered in the Russian Federation.
The effect of the drug Gliatilin is ensured by the properties of its main component. The substance choline alfoscerate is a cholinomimetic, a precursor of acetylcholine.
It has a stimulating effect on cholinergic receptors, largely on central ones. After penetration into the body, under the influence of internal processes, it breaks down into choline and glycerophosphate.
Acts as a substrate in the process of synthesizing acetylcholine and phosphatidylcholine in nerve cell membranes. At the same time, it activates cerebral circulation, metabolic transformations in the central nervous system, and the reticular formation (a section of the brain stem that regulates the activation of the brain cortex).
The substance improves the psycho-emotional state: mood, intellectual activity, ability to concentrate, memory, ability to reproduce and analyze received information. It also enhances learning ability and behavior, eliminates lability of emotions and apathy.
Use in the acute period after traumatic brain injury helps to normalize blood circulation in the brain, bioelectrical activity in the area of injury, and accelerates the disappearance of neurological manifestations.
After penetration of choline alfoscerate into the body, it is absorbed in a significant amount (about 89%) and freely passes through the BBB. It accumulates mainly in the brain (44-46% of the applied dosage), lungs, and liver.
It is excreted from the body mainly through the lungs in the form of carbon dioxide (85%), the remainder is excreted in urine and feces.
The substance has no effect on childbearing function, has no toxic effect on the body.
Average price: 767 rub.
Features of treatment and the choice of dosage form of Gliatilin are determined by the attending physician.
Gliatilin injections
The medicine must be administered intramuscularly and intravenously. In the latter case, the medication is used in the form of infusions (droppers). The drug is combined with saline solution(1 amp. per 50 ml). Glialitin should be administered intravenously at a rate of 60 to 80 drops/min.
If the doctor has prescribed intramuscular injections, then the injections should be administered into the anterior top part thighs (if the patient can handle the syringe himself) or into the stomach. It is not recommended to inject it into the gluteal area, as there is a high probability that Gliatilin liquid will enter the fat layer. In this case, the rate of penetration of the drug will slow down and, accordingly, the therapeutic effect will slow down.
The Gliatilin ampoule must be opened immediately before the procedure. The remaining product is disposed of. For intravenous infusions, only an unopened container is used; if injections are given intramuscularly, then it is informally allowed to use the remainder in the ampoule (subject to sterility and storage for no more than 1 day in the refrigerator).
At acute forms pathologies: daily norm for intramuscular administration - 1 amp., for intravenous administration - from 1 to 3 g. The duration of the course is about 10 days, but if necessary, it can be extended until signs of improvement in the body's condition appear. After this, the drug is used in capsules.
Capsules
Gelatin capsules (tablets) of Gliatilin, according to the instructions for use, must be swallowed whole. Chewing or opening the casing is prohibited. It is better to take the medication shortly before meals.
If the treatment regimen involves taking the drug several times throughout the day, then it is better to take most of it in the morning, and drink the rest in the daytime, since Gliatilin often has a stimulating effect.
At chronic pathologies: 1 caps. (400 mg) x 2-3 times a day. The duration of the course is from 3 to 6 months.
In acute forms: first, injections are used (1 amp per day), after the patient’s condition improves, they are transferred to the oral form of the drug (capsules or syrup). The course is up to six months.
In pediatrics
Gliatilin for children can be used in the form of injections and capsules. Injections are prescribed for acute forms of disorders, as well as in cases where it is difficult for children to swallow a capsule. Whether or not children need to take the drug Gliatilin is determined by the doctor. The treatment regimen and its duration are also determined individually.
During pregnancy and breastfeeding
Animal studies of the properties of Gliatilin have shown that the drug does not have a teratogenic effect on intrauterine development offspring. Such experiments have not been conducted on humans, so the medicine is prohibited for use during pregnancy.
If a woman becomes pregnant during treatment with Gliatilin, she must inform her doctor about this, after which she will have to do the appropriate laboratory tests to determine whether or not there are disturbances in the development of the embryo/fetus.
It is also not advisable for nursing women to combine therapy and lactation, since it is known that the substance can penetrate into milk. During treatment, lactation should be abandoned to prevent unpredictable consequences for the child’s health.
The use of Gliatilin in children is possible only at the discretion of the doctor.
Use Gliatilin in any dosage form prohibited when:
Special instructions
If a patient experiences nausea after using Gliatilin, you should contact your doctor to review the dosage.
Cross drug interactions
At present, no clinically significant reactions have yet been recorded when combining the drug Gliatilin with other drugs. Therefore, it can be prescribed simultaneously with other medications in the same complex scheme therapy.
As a rule, Gliatinin is well accepted by most patients, even with a long cycle of therapy.
In some patients, during the first days or weeks after starting treatment, side effects in the form increased anxiety, agitated state, insomnia. These phenomena are temporary in nature and, as treatment continues, go away on their own without any treatment. Dosage reduction may be necessary for some patients.
One common side effect is nausea. Most often occurs due to secondary dopaminergic stimulation. It also happens: decreased blood pressure, headaches, extremely rarely - abdominal pain, transient clouding of consciousness. In such cases, a dosage reduction is required.
Hypersensitivity reactions are manifested by a skin rash, itching, urticaria, Quincke's edema, and redness of the dermis. Some patients may experience delayed side effects.
The use of high dosages of Gliatilin can cause nausea, increased anxiety, nervous excitement, insomnia.
The developing condition should be reported to your doctor. Usually the effects of an overdose are eliminated after reducing the dosage.
The possibility of replacing Gliatilin with analogues depends on the patient’s diagnosis and the properties of other drugs. Possible options: Nooprin, Gleacer, Choline alfoscerate, Delecite, Cereton, Holitylin. The use of other drugs is carried out only in agreement with the treating specialist.
Veropharm (RF)
Price: amp. (3 pcs.) – 413 rub., (5 pcs.) – 512 rub., caps. (14 pcs.) – 533 rub., (28 pcs.) – 909 rub., (56 pcs.) – 1642 rub.
LS - an analogue of Gliatilin in capsules and injections according to active substance and dosage form. Intended for therapy in acute and rehabilitation periods after TBI, hemorrhagic and ischemic strokes, treatment chronic form insufficiency of blood flow in the brain, cognitive disorders, senile dementia. Prohibited for use in case of personal intolerance, pregnancy, breastfeeding.
In the acute period, injections are prescribed, which can be administered intravenously or intramuscularly; after stabilization (after 10-15 days), the patient is transferred to the oral form of Cerepro.
At chronic conditions capsules are used: 1 pc. three times a day. The duration of the treatment cycle is from 3 months to six months.
Pros:
Flaw:
Gliatilin or Cerepro: which is better?
Despite the identical properties and purpose of drugs, drugs cannot be replaced independently, so as not to inadvertently affect the course of therapy.
Gliatilin is an original Italian drug. It is traditionally believed that such drugs act more effectively and are easier to tolerate. Cerepro is a domestic analogue of an imported nootropic, therefore cheaper than Gliatilin. According to observations, its effect appears after 2-3 days of use.
The development of a child’s psyche is long and complex process, which occurs purely individually and depends on many factors. From how true the becoming is nervous system, depends general health baby. Features of gestation, pregnancy, genetic predisposition, birth injuries and other negative circumstances lead to developmental delays. In this case, children can come to the rescue nootropic drugs, in particular Gliatilin.
Gliatilin - nootropic remedy, the effect of which is to normalize blood circulation and metabolism in the cells of the cerebral cortex.
Once in the blood, the drug breaks down into two components, which take an active part in biochemical processes in the body. Thanks to this, neurons receive greater protection, damaged connections are restored, bypassing the affected areas of the brain. In this case:
Numerous clinical studies have proven the high effectiveness of the drug.
Gliatilin helps restore loss of consciousness, and also improves the condition of young patients who have suffered traumatic brain injury or serious illnesses associated with impaired blood circulation in the brain.
There are two types of medicine: capsules and solution for infusion (intravenous or intramuscular).
The preferred form of drug administration for children of all ages is injection, since it:
According to the instructions, a nootropic can be prescribed for:
Numerous studies have expanded this list. Special attention focuses on the problem of traumatic brain injury. Although this type of injury is extremely rare in childhood, any concussion can affect further development baby.
Most often, head injuries occur in children 3–7 years old and can be accompanied by severe impairment of consciousness.
Gliatilin is prescribed to children as part of complex therapy for traumatic brain injuries, if there is no intracranial bleeding.
In addition, the drug can be prescribed to children for:
The nootropic does not have a mutagenic effect and does not cause developmental disorders, so it can be considered safe for treating children.
But parents should remember that the drug has a potent effect, so self-medication is strictly prohibited. The dosage, duration of therapy and methods of administration are prescribed only by a doctor.
Gliatilin is generally well tolerated, but can sometimes cause adverse reactions in the form:
When unpleasant symptoms You should immediately stop taking the medication and consult a doctor for advice.
The only contraindication to the use of the drug is individual intolerance to its individual components.
When prescribing Gliatilin in the form of injections, it should be remembered that the solution must not be mixed in the same syringe with other drugs.
The drug is taken only under the strict supervision of a neurologist or pediatrician. The duration of treatment depends on the baby’s disease and on average ranges from 1 to 3 months.
It is recommended to take the capsules before meals with plenty of liquid. They are swallowed whole without chewing. The medicine should be taken in the morning, since the medicine has an stimulating effect, and late use can affect sleep.
Newborns and children infancy the drug is prescribed in the form intramuscular injections. The dosage and duration of therapy is determined by the doctor.
For children over two years old, the medicine is first prescribed in the form of injections or droppers, and later capsules are prescribed.
Choice medicines nootropic action is quite wide, so the pediatrician can prescribe to the child similar drug, which is more suitable for a particular situation.
| Name | Release form | Main Components | Indications | Contraindications | Age restrictions | Price, rub. |
| N-nicotinoyl-gamma-aminobutyric acid |
|
| from 3 years old | 73–105 | |
| pills | glycine |
|
| from 2 years | 30–140 | |
| drops | Semax |
|
| from 5 years old | from 400 | |
| calcium hopantenate |
|
| from 3 years old | 360 |
Pantogam is a nootropic drug that improves mental activity and motivates the child to understand the world around him. 
Semax - available in the form of nasal drops, which promotes rapid absorption of the drug 
According to reviews, after taking Picamilon, patients’ feelings of anxiety disappear, sleep normalizes, and their condition improves with motor and speech disorders 
Glycine is well tolerated and has virtually no contraindications.
Most doctors consider Gliatilin effective drug for treatment neurological disorders in the child and restoration of his mental abilities. Expert opinions are based on long-term observations of such children. However official medicine has not yet identified nootropics as a separate class due to the lack of evidence base.
Regarding the replacement of Gliatilin with analogues, the opinions of doctors differ.
Perhaps I am subjective, but in general I have negative attitude to generics. Theoretically, such a drug is completely consistent with the original, but practice shows that very often the similarity does not sufficiently possess the properties of its sample.
Professor M. M. Odinak
http://apteka.uz/novosti_farmacevticheskih_i_medicinskih_kompaniy/gliatilin_-_vchera_segodnya_zavtra
Which helps to cope with genetic disorders and developmental defects in the child. In addition, the above medicine is actively used by neurologists to restore the functions of a child’s brain in case of traumatic brain injuries, as a result of which his thinking process is disrupted and memory deteriorates. Also, the instructions for use for children suggest using the drug “Gliatilin” to remove little patient from a comatose state. Read on for more details about the above medicine.
The above therapeutic nootropic agent is one of a number of neuroprotectors. The instructions for use for children recommend using the drug “Gliatilin” in neurological practice for a long time.
It should be noted that this remedy has proven to be highly effective in many clinical studies. The drug helps restore emotional and cognitive functions.
This nootropic medicine helps restore lost consciousness and rehabilitate patients who have suffered serious illnesses such as ischemic stroke, chronic cerebral circulatory disorders, and traumatic brain injury.
The medicine is an oval-shaped gelatin soft opaque capsule, yellow tint. In their middle there is a viscous colorless solution.
Another form of release of the drug "Gliatilin" for children is colorless glass ampoules, which contain 4 ml of solution. The latter is odorless and colorless.
The nootropic drug should be stored at room temperature. In addition, it is important to reliably limit children’s access to it. If all storage rules are followed, the shelf life of the capsules this tool is about 3 years, and injections - up to 5 years.
The drug is not sold in pharmacies without a special prescription.
This nootropic consists of the following substances:
The capsule shell contains the following substances:
One package contains 14 pcs. such capsules.
The instructions call the drug “Gliatilin” the strongest neuroprotector, which contains about 40% of a substance such as choline. The latter in the human body transforms into its active form - phosphorylcholine.
88% is absorbed when taking Gliatilin orally. Use in children produces the following therapeutic effect:
The above nootropic agent is a cholinomimetic central action, which directly predominantly affects the central nervous system. It should be noted that choline is an active participant in the biosynthesis of acetylcholine. The latter is the main mediator of nervous excitation.
Therefore, experts suggest giving the drug “Gliatilin” to children. Reviews claim that this nootropic does not affect reproductive cycle, does not cause genetic mutations and developmental disorders.
The above substance is excreted from the body by the lungs in the form of carbon dioxide (about 85%), the rest through the intestines and kidneys.
The drug "Gliatilin" for children is very effective for the treatment of the following diseases:
The instructions do not suggest using the drug “Gliatilin” for children if symptoms of hypersensitivity to its components are observed.
It should be noted that in some situations the above nootropic drug may cause side effects. Among them are the following health problems:
Neurologists warn that if the above is observed side effects Parents should stop giving the drug to their child and seek medical help immediately.
Memory, attention and thinking disorders are observed in 20% of children and adolescents, speech disorders, difficulties with reading and writing are recorded in 5–20%, and signs of autism are detected in 17% of patients childhood at an outpatient appointment with a psychiatrist. These figures indicate the prevalence of such problems, for the treatment of which different types therapy, including medicines, for example, Gliatilin.
Gliatilin is a nootropic drug that affects the blood supply and functioning of the brain and nervous system.
It comes in the form of:
Both solution and capsules are used to treat children.
If the solution is used in a hospital during an exacerbation of the disease, then the capsules are suitable for outpatient treatment at home.
The active substance of Gliatilin is choline alfoscerate. Water is used as an auxiliary component in the solution. Capsules contain:
This is interesting! Glycerol makes the contents of the capsules thick and viscous.
Choline alfoscerate, under the action of enzymes in the human body, breaks down into:
Gliatilin has a positive effect on the functioning of the nervous system, improves blood flow in the brain, solves problems associated with insufficient permeability of neuronal membranes and reduced activity of receptors sensitive to acetylcholine.
The experience of using a nootropic in pediatric neurological practice speaks of its high efficiency and good tolerance. The drug helps in the treatment of brain injuries, improves attention, memory, psycho-emotional and muscle tone, increases motor activity, relieves mood instability, weakness and indifference.
Prescription of the drug is justified when:
In pediatrics, the drug is used to treat various diseases associated with disorders of the brain and central nervous system:
Gliatelin is contraindicated only in children with hypersensitivity to the components of the drug. Among the side effects in official instructions indicated:
The manufacturer claims that the nootropic is well tolerated, and if nausea occurs, the dose should be reduced. But in practice, some children may experience the following behavioral abnormalities a few days after the start of treatment:
Many mothers are frightened by such drastic changes in behavior, and they think about stopping taking the drug. The appearance of the above symptoms requires additional consultation with a specialist, dose adjustment or complete discontinuation of Gliatilin.
Only a doctor should prescribe Gliatilin; self-medication is unacceptable.
Gliatilin - drug long-term use. The duration of treatment depends on the child’s illness and can range from 1 to 6 months. Sometimes the positive results of therapy after discontinuation of the nootropic gradually disappear, so it is prescribed in courses to consolidate the effect.
You need to take Gliatilin in the morning. This is due to the fact that the medication can act as a stimulant and negatively affect sleep.
To treat small children, you can puncture the capsule, mix its contents with water and give it to the child in this form.
The drug is prescribed intramuscularly or intravenously in the acute period of the disease, as well as in small children who cannot swallow the capsule.
The domestic analogue of Gliatelin is the drug Tsarepro, which costs slightly less than the original. In addition, there are nootropics in a more convenient form of release for children, for example, Pantogam and Encephabol. The choice of medications is quite extensive, so the doctor can prescribe a different medication for the child based on individual characteristics and indications.
| Drug name | Release form | Active ingredient | Indications | Contraindications | From what age is it used? |
| Tsarepro | capsules | choline alfoscerate |
| from birth | |
| Cortexin | lyophilisate for preparing a solution for intramuscular administration | peptides derived from the cerebral cortex of pigs and cattle |
| individual intolerance to the drug | from birth |
| Pantogam |
| calcium salt of hopantenic acid |
|
|
|
| Encephabol | suspension for oral administration | pyritinol dihydrochloride monohydrate |
|
| from 3 days after birth |
| Aminalon | pills | gamma-aminobutyric acid |
| hypersensitivity to GABA | from birth |
| pills | microencapsulated glycine |
| hypersensitivity to the components of the drug | from 3 months |
Doctors consider Gliatilin an effective drug. Their opinion is based on the observation of positive dynamics in the treatment of children with speech development disorders, psycho-emotional and motor retardation, brain injuries, and abnormalities in the functioning of the nervous system.
To the question “can Gliatilin be replaced with a cheaper one? domestic analogue? Experts do not have a clear answer. Some pediatricians themselves advise this to save budget, but there is an opinion that Tsarepro does not fully replicate the properties of the original drug.
Perhaps I'm subjective, but in general I have a negative attitude towards generics. Theoretically, such a drug is completely consistent with the original, but practice shows that very often the similarity does not sufficiently possess the properties of its sample.
Miroslav Mikhailovich Odinak, doctor medical sciences, Corresponding Member of the Russian Academy of Medical Sciences, Honored Doctor of the Russian Federation, Head of the Department and Clinic of Nervous Diseases of the Military Medical Academy, Chief Neurologist of the Ministry of Defense of the Russian Federation.
http://apteka.uz/novosti_farmacevticheskih_i_medicinskih_kompaniy/gliatilin_-_vchera_segodnya_zavtra
Despite positive results treatment of children with Gliatilin, experts believe that the clinical experience of its use is too small, and the range of use of the drug can be expanded, but this requires further research.
