TESTOSTERONE PROPIONATE Testosterone propionate
›› Testosterone*
Testosteroni propionas
›› G03BA03 TestosteronePharmacological groups: Androgens, antiandrogens
››
Antitumor hormonal agents and hormone antagonists
Nosological classification (ICD-10)
›› C50 Malignant neoplasms of the breastComposition and release form
1 ampoule with 1 ml solution for injection in olive oil contains testosterone propionate 10 or 50 mg (1 or 5% solution); complete with ampoule knife, 10 pcs in a box.
pharmachologic effect
pharmachologic effect- androgenic.
Indications
Hypofunction of the gonads in men, menopause in men, breast cancer, dysfunctional metrorrhagia, menopause in women.
Contraindications
Prostate cancer.
Increased sexual arousal, retention of salts and water in the body, masculinization.
Directions for use and doses
IM or SC, doses are selected individually depending on the diagnosis. For men with eunuchoidism, congenital underdevelopment of the gonads, acromegaly - 0.025 g daily or 0.05 g every 1-2 days. Maintenance dose 0.005-0.01 g daily or every other day. For impotence, male menopause - 10 mg daily or 25 mg 2-3 times a week for 1-2 months. For prostate hypertrophy - 10 mg every other day for 1-2 months. For dysfunctional uterine bleeding- 1 ml of 2.5% solution every other day, 20-30 injections in total.
Best before date
Storage conditions
List B.: In a place protected from light.
* * *
TESTOSTERONE PROPIONATE (Testosteroni propionas). Adrosten-4-ol-17 b-one-3 propionate. Synonyms: Agovirin, Androfort, Androlin, Andronate, Homosteron, Malestron, Oreton F, Perandren, Sterandryl, Synandrone, Testolutin, Testosterone propionate, Testosteronum propionicum, Testoviron, Virormone, etc. White crystalline powder. Practically insoluble in water, easily soluble in alcohol, soluble in vegetable oils. Testosterone is an endogenous male sex (androgenic) hormone. Produced in the male gonads, it is necessary for the formation of genital organs and the development of secondary sexual characteristics in men. Constant production of testosterone begins during puberty and continues until the decline of sexual function. According to modern data, there are specialized androgen receptors in the body. Testosterone circulating in the blood is converted in target organs into 5a-dihydrosterone (using the enzyme 5a-reductase), which binds to androgen receptors and penetrates the cell nucleus. It is also possible that testosterone itself binds to receptors in some tissues. For use in medical practice testosterone propionate is obtained synthetically. It has biological and medicinal properties natural hormone, but is absorbed more slowly and is more persistent in the body than testosterone. Testosterone propionate is used parenterally; when taken orally, it is ineffective (it is quickly destroyed in the liver). In addition to its specific androgenic effect, testosterone, like all androgens, also affects other functions and systems of the body, in particular it affects nitrogen and phosphorus metabolism. It has an anabolic effect and can be considered an endogenous anabolic hormone. Insufficient testosterone content in the body (with insufficient sexual development, after castration, etc.) is usually accompanied by impaired protein anabolism, atrophy of skeletal muscles and increased deposits in subcutaneous tissue and internal organs of adipose tissue. Replacement use of testosterone drugs may help with these changes therapeutic effect. The anabolic effect of testosterone also appears under various pathological conditions accompanied by increased breakdown of proteins (chronic infectious diseases, exhaustion, surgical interventions, severe injuries, etc.) and disorders of calcium and phosphorus metabolism (osteoporosis). Widely applicable testosterone as an anabolic agent is hampered by its strong androgenic effect. Currently, drugs have been obtained that are similar in chemical structure to testosterone, but have a more selective anabolic effect. Testosterone propionate is prescribed mainly to men for sexual underdevelopment, functional disorders in the reproductive system, menopausal syndrome, acromegaly. In some cases, testosterone propionate has a positive effect on prostate hypertrophy: it improves general state, urination disorders are reduced, etc. The administration of testosterone propionate, like other androgens, to women causes inhibition of the gonadotropic function of the pituitary gland, inhibition of the function of the follicular apparatus and ovaries, endometrial atrophy, suppression of the function of the mammary glands. IN medicinal purposes testosterone propionate is sometimes used in women with menopausal vascular and nervous disorders in cases where estrogen drugs are contraindicated (for tumors of the genital organs and mammary glands, uterine bleeding). It is also prescribed simultaneously with radiation therapy for breast and ovarian cancer (usually in women under 60 years of age). In older women, testosterone propionate can be used for dysfunctional uterine bleeding. Testosterone propionate may also have a beneficial effect in early stages hypertension and with angioneurotic forms of angina. In all cases, the drug is used only as prescribed by a doctor, and the patient is carefully monitored during treatment. Used intramuscularly or subcutaneous injections in oil solutions. For men with eunuchoidism, congenital underdevelopment of the gonads, their removal surgically or as a result of injury, as well as for acromegaly, 0.025 g (25 mg) is prescribed daily or 0.05 g (50 mg) every other day or every 2 days. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. Treatment is usually carried out over a long period of time. After improvement clinical picture testosterone propionate is administered in maintenance doses; 0.005 - 0.01 g daily or every other day, or switch to oral methyltestosterone. For impotence due to functional deficiency of the gonads, fatigue and nervous exhaustion, as well as for male menopausal syndrome, 10 mg daily or 25 mg 2-3 times a week is prescribed for 1-2 months. For prostate hypertrophy in the initial stage, take 10 mg every other day for 1 to 2 months. Women over 45 years old with dysfunctional uterine bleeding are prescribed 0.01 - 0.025 g (10 - 25 mg) every other day for 20 - 30 days until the bleeding stops and atrophic cells appear in vaginal smears. You should first exclude malignant neoplasms uterus. For vascular and nervous disorders of menopausal origin in women and the presence of contraindications to the use of estrogens, testosterone propionate is administered 0.01 g (10 mg) every other day or 0.025 g (25 mg) 2 times a week for 2 - 3 weeks. It is preferable to prescribe methyltestosterone in these cases. In patients with angina, a positive effect is sometimes observed when using testosterone 10.0 - 12.5 mg once a week; if well tolerated, the number of injections is increased to two per week (for 3 - 5 weeks). Towards the end of treatment, the dose and number of injections are reduced again. The course of treatment consists of 15 - 20 injections. Positive effect associated with improved blood circulation and metabolic processes in the heart muscle; Favorable changes in the lipid ratio in the blood and an increase in the lecithin/cholesterol ratio are also observed. Best result observed in angioneurotic forms of angina. In cases of severe cardiosclerosis, treatment with hormones is ineffective. At malignant tumors mammary or ovarian testosterone propionate is administered in a dose of 0.05 g (50 mg) daily for several months, then (depending on the results of treatment) the dose is reduced and maintenance doses are prescribed for a long time. As an addition to surgical intervention or radiation therapy the drug is prescribed to women under 60 years of age (older women are recommended to take estrogens). Higher dosages intramuscularly for adults: single 0.05 g (1 ml of 5% solution), daily 0.1 g (2 ml of 5% solution). When treating testosterone propionate and other androgenic drugs, it is necessary to carefully monitor the condition of patients: large doses can cause increased sexual arousal, water and salt retention in the body, dizziness, nausea; Women may experience phenomena of masculinization (virilism): deepening of the voice, excess hair growth on the face and body, facial pastiness, atrophy of the mammary glands. An overdose of drugs for dysmenorrhea can lead to the cessation of menstruation. For prostate cancer, androgen drugs are contraindicated. Release form: 1% or 5% solution in oil in 1 ml ampoules. Storage: List B. In a place protected from light.
. 2005 .
Synonyms:TESTOSTERONE PROPIONATE- Testosteroni propionas. Testosteronum propionicum. Synonyms: agovirin, androfort, andromin, hadronate, homosterone virormon, malesterone, synandron, testviron, etc. Properties. White crystalline powder, practically insoluble in water, easily dissolved...
- … Synonym dictionary
TESTOSTERONE PROPIONATE (Testosteroni propionas). Adrosten 4 ol 17 b she 3 propionate. Synonyms: Agovirin, Androfort, Androlin, Andronate, Homosteron, Malestron, Oreton F, Perandren, Sterandryl, Synandrone, Testolutin, Testosterone propionate,… … Dictionary medical supplies
Steroid hormones that determine sexual differentiation in humans and animals in the embryonic period, the nature of secondary sexual characteristics, and functional activity reproductive system and the formation of specific behavioral... ... Medical encyclopedia
Age-related androgen deficiency in men (PADAM partial androgen deficiency in aging male): age-related decrease in androgen levels in men. In 1994, at a working meeting of the Austrian Society of Urology, this term was adopted instead of the male one... Sexological encyclopedia
Active ingredient ›› Testosterone (mixture of esters) (Testosterone) Latin name Omnadren 250 ATX: ›› G03BA03 Testosterone Pharmacological groups: Androgens, antiandrogens ›› Antitumor hormonal agents and... ... Dictionary of medicines
- (Testoenatum). Combination drug, containing a mixture of a solution in oil of testosterone enanthate and testosterone propionate. Similar drugs produced abroad under the name etc. Testosterone enanthate (Testosteroni oenanthas) is... ... Dictionary of medicines
TESTENATE (Testoenatum). A combined preparation containing a mixture of a solution in oil of testosterone enanthate and testosterone propionate. Similar drugs are produced abroad under the name and others. Testosterone enanthate (Testosteroni oenanthas) ... ... Dictionary of medicines
Testosterone ... Wikipedia
METHYLTESTOSTERONE- Methyltestosteronum. Synonyms: androral, virormon oral, glazo sterandil, gormal, madiol, methandren, oretone, testoral, etc. Properties. White crystalline powder, odorless and tasteless. Practically insoluble in water; slightly soluble in plants... Domestic veterinary drugs
Testosterone propionate: instructions for use and reviews
Latin name: Testosterone Propionate
ATX code: G03BA03
Active substance: testosterone
Manufacturer: JSC "DALKHIMFARM" (Russia)
Updating the description and photo: 26.10.2018
Testosterone propionate is an androgenic drug.
Dosage form of Testosterone propionate - solution for injection in olive oil 1% and 5%: oily liquid of light yellow or light green color, with a specific odor [1 ml in ampoules: in a cardboard pack of 10 ampoules complete with an ampoule knife/scarifier , or 5 ampoules in a blister pack, in a cardboard box, 2 packages complete with an ampoule knife/scarifier (the ampoule knife/scarifier is placed only in packs with a certain type ampoules, without breakage point/ring)].
Composition of 1 ampoule:
Testosterone propionate is a drug that has androgenic and anabolic effects (i.e., regulating the function of the male gonads and protein synthesis).
Testosterone stimulates the function and development of the external genitalia, seminal vesicles, prostate and secondary male sexual characteristics. Provides stimulation of spermatogenesis, participates in the formation of male sexual behavior and the construction of the body constitution. Under its influence, the production of follicle-stimulating and luteotropic hormones decreases.
Testosterone is an antagonist of the female sex hormones estrogen. It has an antitumor effect against tumors in the mammary glands in women.
The drug has an anabolic effect and, as a result, reduces the amount of fat deposits, stimulates protein synthesis and retains a number of elements necessary for it in the body.
Under the influence of this hormone, muscle mass grows and the degree of calcium fixation in the bones increases.
If the patient receives sufficient protein nutrition while using Testosterone Propionate, the production of erythropoietin, one of the kidney hormones that controls erythropoiesis, is also stimulated.
After intramuscular or subcutaneous administration, testosterone is slowly absorbed, after which it enters the bloodstream and organs, in which it is reduced to 5-α-dihydrotestosterone, which interacts with cell membrane receptors, then penetrates the cell nucleus.
Testosterone is characterized by high binding to plasma proteins - 98%. Metabolized in the liver. It is excreted primarily through the kidneys. In unchanged form, about 6% of the substance is excreted through the intestines.
For men:
For women:
Testosterone propionate is intended for intramuscular or subcutaneous administration. Single dose usually amounts to 1 ml of solution. The interval between injections is 1–2 days.
The doctor determines the course of treatment for women individually depending on the indications and severity of symptoms. For dysfunctional uterine bleeding, 1–2 ml of a 1% solution is prescribed every other day. Course – 20–30 injections.
When using the drug in higher doses, salt and water retention and increased sexual arousal are possible. Men may experience frequent erections. Women may experience masculinization (deepening of the voice, growth of hair on the face and body), atrophy (decreased mass) of the mammary glands, facial pastiness (loss of elasticity and whitening of the facial skin against a background of mild swelling).
If large doses of Testosterone propionate are prescribed to women for the treatment of dysmenorrhea, a complete cessation of menstruation is possible.
In boys and adolescents, the drug may accelerate puberty, promote enlargement of the genital organs.
When using the drug in high doses for a long time, the above-described side effects and symptoms associated with androgen dependence occur. Treatment in this case should be suspended until the condition stabilizes, after which Testosterone propionate should be prescribed in lower doses.
In women with an overdose, menstruation may stop.
Before prescribing the drug, men are advised to carry out medical examination to exclude prostate cancer, since Testosterone propionate increases the risk of developing prostate hyperplasia.
When administering the drug, care should be taken to prevent the solution from entering the vessels. To avoid the development of unwanted side effects, including local ones, it is recommended to administer the product very slowly.
During treatment, monitoring of the condition of patients suffering from migraine is required, kidney diseases, arterial hypertension, heart failure, epilepsy.
Testosterone propionate increases the tendency to form blood clots, so it should be used with caution when treating patients who have recently undergone injury or surgery.
In case of long-term therapy, it is necessary to monitor the following indicators: functional state liver, testosterone concentration, hemoglobin level and hematocrit.
In children, testosterone can cause accelerated growth, premature closure of the pineal growth plate and excessive maturation bone tissue.
Pregnant and breastfeeding women are prohibited from taking the drug, as it has a teratogenic effect.
Data on the safety of testosterone use in childhood are absent, therefore the drug is not prescribed in pediatrics.
Testosterone propionate is contraindicated in patients with impaired renal function.
Testosterone propionate is contraindicated in patients with impaired liver function.
The drug is not prescribed to elderly men.
According to the instructions, Testosterone propionate enhances the effects anabolic drugs, vitamins, oral anticoagulants and medicines containing phosphorus and calcium. Its effect is reduced by barbiturates, carbamazepine, phenytoin, phenylbutazone, rifampicin, ethanol.
With simultaneous use of adrenocorticotropic hormone or corticosteroids, the risk of edema increases.
Under the influence of androgens, the effect of hypoglycemic drugs and insulin may be enhanced, which may require a reduction in their dose.
Testosterone slows down the elimination of cyclosporine.
For patients with severe hypogonadism, Testosterone propionate is recommended to be used in combination with estrogens and function-stimulating agents. thyroid gland.
Analogues of Testosterone propionate are: Andriol, Androzhel, Nebido, Testoviron, Synandron, etc.
Shelf life – 5 years.
Store away from sunlight, out of reach of children at a temperature of 5–25 °C.
Release form: Liquid dosage forms. Injection.
Active ingredient: testosterone propionate;
1 ml of solution contains testosterone propionate in terms of 100% substance 50 mg;
excipient: ethyl oleate.
Pharmacodynamics. Testosterone propionate has a specific androgenic effect: it stimulates the development and function of the external genitalia, prostate gland, seminal vesicles, as well as secondary sexual characteristics in men (voice, hair). Participates in the formation of body constitution and sexual behavior in men, enhances libido and potency, stimulates spermatogenesis. Reduces the production of luteotropic and follicle-stimulating hormones. Testosterone is an antagonist of female sex hormones - estrogens, and has an antitumor effect in breast tumors in women. It has an anabolic effect, which is manifested in stimulation of protein synthesis, reduction in fat deposition, retention in the body of potassium, phosphorus, sulfur necessary for protein synthesis, increased fixation of calcium in bones and increased muscle mass. With sufficient protein nutrition stimulates the production of erythropoietin.
Pharmacokinetics. After intramuscular or subcutaneous administration, it is slowly absorbed from the injection site. Testosterone circulating in the blood reaches target organs, where it is reduced to 5-α-dihydrotestosterone, which interacts with cell membrane receptors and penetrates the cell nucleus. Up to 98% of the drug in the blood plasma is bound to proteins, mainly globulins. Metabolized in the liver to low-active and inactive metabolites, which are excreted from the body in the urine. Approximately 6% of the drug is excreted unchanged by the intestines.
Pharmaceutical characteristics
Basic physicochemical characteristics: oily liquid of light green or light yellow color with a specific odor.
Replacement therapy with primary and secondary hypogonadism, eunuchoidism; impotence of endocrine origin; due to , ; caused by androgen deficiency; ; menopausal disorders in women (in combination with estrogens); dysfunctional uterines with hyperestrogenism; , accompanied by premenstrual painful tension of the mammary glands; , .
Important! Get to know the treatment
For men with eunuchoidism, congenital underdevelopment of the gonads, their removal surgically or as a result of injury, as well as acromegaly, the drug is prescribed intramuscularly or subcutaneously at 25-50 mg every other day or every 2 days. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. After the clinical picture improves, Testosterone propionate is administered in maintenance doses of 5-10 mg daily or every other day. With impotence of endocrine origin, as well as with male menopause accompanied by vascular and nervous disorders, Testosterone propionate is prescribed 10 mg daily or 25 mg 2-3 times a week for 1-2 months. For treatment male infertility The drug is used in doses of 10 mg 2 times a week for 4-6 months or 50 mg every other day for 10 days. For pathological male menopause, the drug is prescribed at a dose of 25 mg 2 times a week for 2 months with a one-month break. On initial stages prostate hypertrophy, administer 10 mg once every 2 days for 1-2 months.
For women over 45 years of age with dysfunctional uterine bleeding, prescribe 10-25 mg every other day for 20-30 days until the bleeding stops and atrophic cells appear in vaginal smears.
Like all oil solutions, Testosterone propionate is administered intramuscularly. Care must be taken to ensure that the substance being injected does not enter the vessel. By administering the solution very slowly, short-term reactions that sometimes occur during or immediately after injection can be avoided. oil solution(urge to cough, seizures, respiratory depression).
Prescribe with caution to patients with heart failure, arterial hypertension, epilepsy, migraine, and impaired renal function.
In patients with a history of cardiac, renal, or hepatic impairment, androgen use may cause complications with or without congestive heart failure. Caution should be exercised when using the drug in patients with conditions causing fluid retention and causing development swelling. Use the drug with caution in patients with porphyria.
During treatment with the drug, liver and kidney function indicators, thyroid function and blood sugar levels should be monitored.
Before starting treatment in men, it is necessary to exclude the diagnosis, since when using the drug androgens increase the risk of developing prostatic hyperplasia. WITH for preventive purposes Regular prostate examinations are recommended.
In patients taking androgens for long period, besides laboratory measurements concentration of Testosterone, it is necessary to check the following laboratory parameters: hemoglobin, hematocrit (initially - every 3 months, then - once a year) and functional tests liver.
Due to a possible tendency to blood clots, the drug should be prescribed with caution to men after recent surgery or injury.
Drug abuse or addiction. Androgens should not be used to enhance muscle development in healthy people and to improve physical abilities.
The ability to influence the reaction rate when driving a vehicle or working with other mechanisms
While taking the drug, you should refrain from driving vehicles and operating other mechanisms.
From the reproductive system and mammary glands: increased sexual arousal, increased libido and frequent erections, pain in the mammary glands. When using high doses in men, inhibition of spermatogenesis and testicles is possible. Androgens in men can cause prostate hyperplasia, the growth of the prostate. Women may experience phenomena of masculinization (virilism): deepening of the voice, excess hair growth on the face and body, facial pastiness, suppression of ovarian function, menstruation disorders, atrophy of the mammary glands and endometrial tissue, oily skin, clitoral hypertrophy. Virilization may be irreversible even after testosterone use is stopped.
From the outside respiratory system: respiratory disorders, sleep apnea.
From the musculoskeletal system: pain in the legs, muscles.
Gastrointestinal disorders: , . Hepatobiliary disorders: increased levels of aminotransferases, liver dysfunction, jaundice, cholestatic, cases have been reported when using high doses over a long period.
From the blood system and lymphatic system: isolated cases, tendency to thrombosis, increased hematocrit, inhibition of blood clotting factors.
From the skin and its derivatives: various skin reactions, including seborrhea, baldness, itching.
Metabolic and nutritional disorders: weight gain, impaired glucose metabolism, increased levels of low-density lipoproteins, decreased levels of high-density lipoproteins.
Neurological disorders: increased sweating, nervousness, .
General disorders and condition of the injection site: pain at the injection site, subcutaneous pain at the injection site; Long-term treatment with Testosterone propionate or its use in high doses can sometimes lead to an increased incidence of fluid retention and edema; hypersensitivity reactions, incl. in the form of an increase in temperature and a feeling of heat throughout the body.
At combined use with substances that are inducers of microsomal liver enzymes (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin), the effect of testosterone may be weakened. In cases of severe hypogonadism, Testosterone propionate can be combined with drugs that stimulate thyroid function, estrogens.
Enhances the effect anabolic agents, vitamins, drugs containing calcium, phosphorus, slows down the elimination of cyclosporine.
Androgens may increase glucose tolerance and reduce the need for insulin or oral antidiabetic agents in individuals with diabetes.
Androgens can affect the metabolism of other drugs (an increase in serum concentrations of oxyphenbutazone was noted). In addition, testosterone and its derivatives have been reported to increase the activity of oral anticoagulants, which may require dose adjustment. Regardless of this fact, you should always adhere to the restrictions regarding intramuscular injections, patients with acquired or hereditary disorders blood clotting.
Concomitant use of Testosterone and adrenocorticotropic hormone or corticosteroids may increase the risk of edema.
Barbiturates and alcohol reduce testosterone activity.
Individual intolerance to the drug, prostate or breast cancer in men, current or history of liver tumors, severe liver dysfunction, hypercalcemia, untreated congestive .
When using the drug in high doses or for a long time, side effects described in the appropriate section may develop. In this case, the drug should be discontinued and, after the disappearance of androgen-dependent side effects, continued in smaller doses. If necessary, carry out symptomatic treatment.
An overdose of the drug can lead to the cessation of menstruation.
Use during pregnancy or breastfeeding
There is insufficient data on the use of the drug during pregnancy or lactation. Given the characteristic virilizing effect of the drug on the fetus, its use is contraindicated during pregnancy or breastfeeding. The use of the drug should be discontinued if pregnancy is diagnosed.
The safety and effectiveness of use in children have not been studied, therefore the drug is not recommended for use in pediatric practice. The use of Testosterone in children along with masculinization can cause accelerated growth and maturation of bone tissue, as well as premature closure of the epiphysis growth zone, which will result in a decrease in final growth.
Best before date. 2 years. Do not use the drug after the expiration date indicated on the package. Store in original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children.
On prescription
1 ml per ampoule. 5 or 10 ampoules per pack. 5 ampoules in a blister. 1 or 2 blisters per pack.
And also the auxiliary ingredient ethyl oleate.
The solution is an oily liquid that has a light yellow or green tint. The solution has a specific smell. Testosterone is sold in ampoules of 1 ml, the package contains 10 ampoules. The oil solution can be 1% or 5%.
Wikipedia indicates that the drug provides pronounced anabolic and androgenic activity, regulating the process of protein synthesis and the function of the male gonads.
Testosterone Propionate has a specific androgenic effect on the body. Its effect on the body stimulates the development and function of the external genitalia, prostate, seminal vesicles, and secondary male sexual characteristics. Testosterone takes part in the formation of male sexual behavior, and also participates in the construction of the body constitution and provides stimulation of spermatogenesis. Under the influence of testosterone, the production of luteotropic and follicle-stimulating hormones decreases.
After performing subcutaneous or intramuscular injection the substance is slowly absorbed from the place where it was injected. Once in the bloodstream, testosterone gradually enters the organs, where it is reduced to 5-α-dihydrotestosterone, which interacts with cell membrane receptors. It then penetrates into the cell nuclei. In blood plasma, 98% of testosterone is bound to proteins. Metabolism occurs in the liver, metabolites are excreted from the body through the kidneys. Another 6% is excreted unchanged through the intestines.
A testosterone injection is indicated for men who have sexual underdevelopment, disorders of the reproductive system of a functional nature, menopause (in a man’s mature years), as well as related vascular and nervous system. The drug is also indicated for prostate hypertrophy, acromegaly, eunuchoidism, associated with endocrine disorders, post-castration syndrome, oligospermia.
For women, the drug is indicated for nervous and vascular disorders that are associated with the period, for the treatment of ovarian and breast cancer (women under 60 years of age). Testosterone is prescribed for dysfunctional uterine bleeding in elderly women; with, which is accompanied by tension in the mammary glands in the premenstrual period; at , .
Sportswear indicates that the product should not be used when the following diseases and states:
Testosterone is not prescribed to patients with severe asthenia, elderly men, women with and.
During treatment with testosterone, in particular when taking large doses, the following side effects may be observed:
If a woman takes large doses of the drug for treatment , she may stop menstruating completely.
In boys and adolescents, when treated with the drug, puberty may become too active and the genitals may become enlarged.
In addition, the following side effects may occur:
When taking Testosterone Propionate, the instructions for use must be carefully followed by the patient. The instructions stipulate that a solution of 1% or 5% is administered to the patient subcutaneously or intramuscularly, 1 ml. The interval between injections is 1-2 days, the course of treatment lasts from two weeks to several months.
How to take Testosterone Propionate for women is determined by the doctor depending on the disease and symptoms. At dysfunctional bleeding from the uterus 1-2 ml of 1% solution is administered for about one month.
At eunuchoidism , acromegaly , congenital underdevelopment of the gonads 25-50 mg of the drug is administered once every two days. The duration of therapy depends on its effectiveness. Later, a maintenance dose is prescribed - 5-10 mg every other day.
At menopause in men , and also when impotence of endocrine origin 10 mg of medication is prescribed every day or 25 mg 2-3 times a week. Treatment should last 2-3 months.
At prostatic hypertrophy for 1-2 months, 10 mg is administered every other day.
How to inject Testosterone Propionate with male infertility , is determined by a specialist, taking into account the individual characteristics of the body.
Doctors do not recommend taking the drug to healthy people to develop muscles and increase endurance. However, with sports training and strong physical activity Some trainers recommend a course of Testosterone Propionate alone or a combination of this drug with other drugs. For example, a course is assigned in parallel Winstrol . The drug Winstrol is anabolic steroid. A combined course of Testosterone with drugs is also possible , and etc.
If the drug is administered in large doses over a long period of time, problems may subsequently occur. side effects which are described above. In this situation, treatment should be suspended and can be continued only after the symptoms associated with androgen dependence disappear. In this case, smaller doses of testosterone should be administered.
In case of an overdose, women may stop menstruation.
The effect of Testosterone Propionate is reduced if you combine it with Rifampicin, barbiturates, Phenylbutazone, Carbamazepine, Phenytoin.
If the patient has severe hypogonadism, it is recommended to combine Testosterone Propionate with , with agents that stimulate thyroid function.
The drug enhances the effect of vitamins, anabolic drugs, drugs that contain phosphorus and calcium. Testosterone slows down elimination.
Under the influence of androgens, the hypoglycemic effect of insulin may increase; therefore, a reduction in the dose of the hypoglycemic agent may be necessary.
Possible effect on the metabolism of a number of drugs. There is also evidence that Testosterone increases the level of activity of oral anticoagulants. Sometimes there is a need to reduce the dose of the latter.
When taking Testosterone and corticosteroids or adrenocorticotropic hormone simultaneously, the risk of edema increases.
Testosterone activity decreases with simultaneous intake of alcohol and barbiturates.
You can buy the medicine at the pharmacy with a prescription.
The drug should be kept away from light and away from children. Its storage temperature is from 15 to 25 degrees Celsius.
The solution can be stored for 2 years. In this case, you should consider how to store Testosterone Farmak correctly.
When injecting the solution, it is important to ensure that it does not get into the vessels. To avoid negative local and general reactions, you need to inject the product very slowly.
When treating with Testosterone, it is necessary to monitor the body condition of people suffering from arterial hypertension, , kidney diseases, , heart failure.
Before you start administering the drug, you need to conduct an examination and rule out prostate cancer in men, as the likelihood of prostate hyperplasia increases.
When treating children with Testosterone, their accelerated growth and excessive maturation of bone tissue may be observed. The growth plates of the pineal gland may also close prematurely.
Those patients who take this medicine for a long period of time need to monitor some laboratory parameters: Testosterone concentration, hematocrit, and also perform liver function tests.
Because this drug may make you more prone to blood clots, you should use it cautiously after you have had recent surgery or injury.
When treating with the drug, it is advisable to refrain from driving and performing other actions that require precision.
Analogues of Testosterone Propionate are other drugs that contain testosterone. These are drugs Androgel , Synandrone , Testoviron and etc.
Due to the lack of data on the safety of such treatment, the drug is not recommended for use in the treatment of children.
Since Testosterone Propionate can provoke the development of a teratogenic effect, the drug is contraindicated for the treatment of and. It is especially dangerous to take it in the first trimester of pregnancy.
(Testosterone Propionate)active substance: testosterone propionate;
1 ml of solution contains testosterone propionate in terms of 100% substance 10 mg or 50 mg;
Excipients: ethyl oleate.
Injection.
Androgens. ATC code. G03B A03.
Replacement therapy for primary and secondary hypogonadism, eunuchoidism; impotence of endocrine origin, post-castration syndrome, male menopause; infertility as a result of impaired spermatogenesis, oligospermia; osteoporosis caused by androgen deficiency; mammary cancer; menopausal disorders in women (in combination with estrogens); dysfunctional uterine bleeding due to hyperestrogenism; mastopathy, accompanied by premenstrual painful tension of the mammary glands; endometriosis, uterine fibroids.
Individual intolerance to the drug, prostate cancer or breast cancer in men, prostatic hyperplasia, urinary disorders, gynecomastia, impaired liver and kidney function, hypercalcemia, heart failure, myocardial infarction, edema, diabetes mellitus, severe asthenia in patients, elderly age men, pregnancy and lactation.
For men with eunuchoidism, congenital underdevelopment of the gonads, their removal surgically or as a result of injury, as well as acromegaly, the drug is prescribed intramuscularly or subcutaneously at 25-50 mg every other day or every 2 days. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. After the clinical picture improves, Testosterone propionate is administered in maintenance doses of 5-10 mg daily or every other day. For impotence of endocrine origin, as well as for male menopause, accompanied by vascular and nervous disorders, Testosterone propionate is prescribed 10 mg daily or 25 mg 2-3 times a week for 1-2 months. For the treatment of male infertility, the drug is used in doses of 10 mg 2 times a week for 4-6 months or 50 mg every other day for 10 days. For pathological male menopause, the drug is prescribed 25 mg 2 times a week for 2 months with a month's break. In the initial stages of prostate hypertrophy, 10 mg is administered once every 2 days for 1-2 months.
Women over 45 years old with dysfunctional uterine bleeding are prescribed 10-25 mg every other day for 20-30 days until the bleeding stops and atrophic cells appear in vaginal smears.
When using the drug in high doses or for a long time, side effects described in the appropriate section may develop. In this case, the drug is discontinued, and after the disappearance of androgen-dependent side effects, it is continued in smaller doses. If necessary, carry out symptomatic treatment.
An overdose of the drug can lead to the cessation of menstruation.
Due to the possible teratogenic effect of androgens, prescribing the drug during pregnancy (especially in the first trimester) and breastfeeding is contraindicated.
The safety and effectiveness of use in children have not been studied, so the drug is not recommended for use in pediatric practice.
Like all oil solutions, Testosterone propionate is administered intramuscularly. Care must be taken to ensure that the substance being injected does not enter the vessel. By administering the solution very slowly, it is possible to avoid the occurrence of short-term reactions that are sometimes observed during or immediately after injection of the oil solution (the urge to cough, coughing fits, respiratory depression).
During treatment, it is necessary to monitor the condition of patients with heart failure, arterial hypertension, epilepsy, migraine, and renal dysfunction.
Before starting treatment in men, it is necessary to exclude the diagnosis of prostate cancer, since when using the drug androgens increase the risk of developing prostatic hyperplasia.
The use of Testosterone in children along with masculinization can cause accelerated growth and maturation of bone tissue, as well as premature closure of the growth plate of the epiphysis, which will result in a decrease in final growth. Common acne may appear.
In patients taking androgens for a long period, in addition to laboratory measurements of Testosterone concentration, it is necessary to check the following laboratory parameters: hemoglobin, hematocrit (initially every 3 months, then once a year) and liver function tests.
Due to a possible tendency to blood clots, the drug should be prescribed with caution to men after recent surgery or injury.
Drug abuse or addiction. Androgens should not be used to enhance muscle development in healthy individuals or to enhance physical performance.
The ability to influence the reaction rate when driving a vehicle or working with other mechanisms.
While taking the drug, you should refrain from driving vehicles and operating other mechanisms.
When combined with substances that are inducers of microsomal liver enzymes (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin), the effect of Testosterone may be weakened. In cases of severe hypogonadism, Testosterone propionate can be combined with drugs that stimulate thyroid function, estrogens.
Enhances the effect of anabolic agents, vitamins, drugs containing calcium, phosphorus, and slows down the elimination of cyclosporine.
Androgens can enhance the hypoglycemic effect of insulin, so it may be necessary to reduce the dose of the hypoglycemic drug.
Androgens can affect the metabolism of other drugs (an increase in serum concentrations of oxyphenbutazone was noted). In addition, Testosterone and its derivatives have been reported to increase the activity of oral anticoagulants, which may require dose adjustment. Regardless of this fact, restrictions regarding intramuscular injections should always be adhered to in patients with acquired or hereditary bleeding disorders.
Co-administration of Testosterone and adrenocorticotropic hormone or corticosteroids may increase the risk of edema.
Barbiturates and alcohol reduce testosterone activity.
Pharmacodynamics. Testosterone propionate has a specific androgenic effect: it stimulates the development and function of the external genitalia, prostate gland, seminal vesicles, as well as secondary sexual characteristics in men (voice, hair). Participates in the formation of body constitution and sexual behavior in men, enhances libido and potency, stimulates spermatogenesis. Reduces the production of luteotropic and follicle-stimulating hormones. Testosterone is an antagonist of female sex hormones - estrogens, and has an antitumor effect in breast tumors in women. It has an anabolic effect, which is manifested in stimulation of protein synthesis, reduction in fat deposition, retention in the body of potassium, phosphorus, and sulfur necessary for protein synthesis, increased fixation of calcium in bones and increased muscle mass. With sufficient protein nutrition, it stimulates the production of erythropoietin.
Pharmacokinetics. After intramuscular or subcutaneous administration, it is slowly absorbed from the injection site. Testosterone circulating in the blood reaches target organs, where it is reduced to 5-α-dihydrotestosterone, which interacts with cell membrane receptors and penetrates the cell nucleus. Up to 98% of the drug in the blood plasma is bound to proteins, mainly globulins. Metabolized in the liver to low-active and inactive metabolites, which are excreted from the body in the urine. Approximately 6% of the drug is excreted unchanged by the intestines.
Basic physical and chemical properties: oily liquid of light green or light yellow color, with a specific odor.
