). 2-(para-Aminobenzenesulfamido)-thiazole. Synonyms: Amidotiazol, Aseptosil, Azoseptale, Cibazol, Eleudron, Poliseptil, Pyrisulfon, Sulfathiazole, Sulphathiazolum, Thiazamide, etc. White or white with a slightly yellowish tint, odorless crystalline powder. Very little soluble in water, little in alcohol, soluble in diluted mineral acids and solutions of caustic and carbonic alkalis. Norsulfazole is effective against infections caused by hemolytic streptococcus, pneumococcus, gonococcus, staphylococcus, and E. coli. The drug is easily absorbed from gastrointestinal tract and is quickly excreted from the body. It is excreted primarily in the urine, mainly in a free, non-acetylated form. Used internally for pneumonia, meningitis, staphylococcal and streptococcal sepsis and other infectious diseases. For pneumonia and meningitis, adults are prescribed 2 g for the first dose, then 1 g every 4 to 6 hours until the body temperature decreases; in the future, take 1 g every 6 - 8 hours. In total, during the course of treatment the patient takes 20 - 30 g of the drug. At staphylococcal infections For the first dose, 3-4 g are prescribed, and then 1 g 4 times a day. The course of treatment lasts 3 - 6 days. For patients with dysentery, the drug is prescribed in the same way as sulfadimezin (see). For children, norsulfazole is prescribed every 4 - 6 - 8 hours in the following single doses: from 4 months to 2 years - 0.1 - 0.25 g, from 2 to 5 years - 0.3 - 0.4 g, from 6 to 12 years - 0.4 - 0.5 g. For the first dose, give a double dose. Higher doses for adults orally: single 2 g, daily 7 g. When using norsulfazole, it is recommended to maintain increased diuresis (introducing 2 - 3 liters of liquid into the body per day: after each dose of the drug, drink 1 glass of water with the addition of 1/2 teaspoon of sodium bicarbonate or a glass of Borjomi). The drug is usually well tolerated, but nausea and, in rare cases, vomiting are possible. Due to the advent of more effective chemotherapeutic agents, the use of norsulfazole is relatively limited. Release forms: powder; tablets of 0.25 and 0.5 g in a package of 10 pieces. Storage: List B. In a well-closed container.
Dictionary of medicines. 2005 .
Synonyms:Norsulfazole... Spelling dictionary-reference book
Noun, number of synonyms: 1 medicine (1413) ASIS Dictionary of Synonyms. V.N. Trishin. 2013… Dictionary of synonyms
NORSULFAZOLE- Norsulfazolum. Synonyms: azoseptol, sulfathiazole, thiazamide, cibazole. Properties. White or slightly yellowish crystalline powder, poorly soluble in water and slightly soluble in alcohol. Release form. Available in powder and tablets of 0.25 and 0.5 g. Effective... Domestic veterinary drugs
NORSULFAZOLE- (Norsulfazolum; FH, list B), antibacterial agent from the group of sulfonamides. White or white with a slightly yellowish tint, odorless crystalline powder. Very slightly soluble in water, slightly soluble in alcohol, soluble in diluted... ... Veterinary encyclopedic dictionary
A drug from the group of sulfonamide drugs (See Sulfonamide drugs). Used in tablets and powders for treatment infectious diseases(sore throat, pneumonia, dysentery, etc.) ... Great Soviet Encyclopedia
Norsulfazole, norsulfazoles, norsulfazole, norsulfazoles, norsulfazole, norsulfazolam, norsulfazole, norsulfazoles, norsulfazole, norsulfazoles, norsulfazole, norsulfazoles (
II. Pharmacological
Based on the ability of sulfonamides to be eliminated from the body over time:
It is necessary to increase the first doses of sulfonamides by 2–3 times (loading dose). It is necessary for the next doses to be maintenance.
III. Depending on the application:
1. On lung microorganisms.
2. On the intestines (phthalazole).
3. Urinary tract(urosulfan).
4. Microflora of the eyes (sodium sulfacyl).
General description : Sulfonamide preparations are white or white with a yellowish tint, odorless crystalline substances. The exceptions are sulfapyridazine, which has a yellow color, and salazopyridazine - orange color powder.
General reactions authenticity:
1. For the free amino group:
A. Diazotization – nitrogen coupling:
b. Lignin test:
2. With Br 2, I 2:
3. On the sulfo group. Wet mineralization:
4. Pyrolysis. They give melts with individual coloring:
5. The presence of acidic properties in sulfonamide allows, if necessary, to obtain a sodium derivative and then react with copper sulfate (see the colors of the reaction products in the table below):
6. It is also possible to carry out hydrolysis and determine substituents (The presence of phthalic acid in phthalazole makes it possible to carry out a reaction with resorcinol).
7. For the azo group (discoloration occurs):
8. Sodium derivatives react with Na (flame coloring and with zinc acetate).
NaCl + Zn[(UO 2) 3 (CH 3 COO) 8 ] + CH 3 COOH + 9H 2 O à NaZn[(UO 2) 3 (CH 3 COO) 9 ] 9H 2 O¯ + HCl
9. Solutions of sulfonamide drugs in the presence of caustic alkalis, with the addition of a 1% solution of sodium nitroprusside and subsequent acidification with mineral acid, form red or red-brown colored solutions (streptocide, soluble streptocide, sulgin, sulfacyl sodium, urosulfan) or precipitates (ethazol, norsulfazole, sulfadimezin).
| Name | Solubility | Effects of reactions | |||
| H2O | HCl | NaOH | Private | ||
| NaOH, CuSO 4 | Swims. | ||||
| Streptocide. | MR | LR | R | Green-turquoise | |
| Streptocide soluble. | R | LR | LR | Green | Purple-blue color, smell of ammonia and aniline |
| Sulgin. | OMR | t° | - | Blue solution | Purple-red color, ammonia smell |
| Etazol. | Poland | MR | LR | Grass-green sediment turning black | Dark brown color, smell of hydrogen sulfide |
| Norsulfazole. | OMR | R | R | Dirty purple precipitate fading to dark purple | Dark brown color, smell of hydrogen sulfide |
| Sulfadimezin. | Poland | LR | LR | Yellow-green precipitate turning into red-brown | Dark brown color |
| Phthalazol. | Poland | LR | Dirty gray-turquoise | Dark brown color | |
| Salazodimethoxin. | MR | LR | Dark brown color | ||
| Urosulfan. | MR | LR | LR | Bright turquoise, needle-like crystals appear on the wall of the test tube when standing | Purple-red color, ammonia release |
| Sulfacyl-Na. | LR | The sediment is blue with a greenish tint (bluish-turquoise) | Dark brown color | ||
| Salazopyridazine. | MR | LR | Green-brown | Dark brown color | |
| Sulfapyridazine-Na. | Taupe |
General methods quantification:
1. Nitritometry.
2. Bromatometry: The method is based on the halogenation reaction of sulfonamides. Titrate with a solution of potassium bromate in acidic environment in the presence of bromide. The end of the titration is determined either by the discoloration (with bromine) of the methyl orange indicator, or iodometrically:
KBrO 3 + 5KBr + 6HCl à 3Br 2 + 6KCl + 3H 2 O
Br 2 + 2KI à I 2 + 2KBr
3. Reverse iodatometry f=1/4. KIO 3.
4. Reverse iodochlorometry: Like bromatometry, this method is based on the halogenation reaction. Iodization is carried out using a titrated hydrochloric acid solution of iodine chloride. The excess of the latter is determined iodometrically:
ICl + KI à I 2 + KCl
I 2 + 2Na 2 S 2 O 3 à 2NaI + Na 2 S 4 O 6
5. Acid-base titration.
A. acidimetry for sodium salts: Titrant HCl, indicator – methyl orange in an alcohol-acetone medium. f=1.
b. alkalimetry if K dis of a sodium derivative is 10 -7 -10 -8.
V. if Kdis = 10 -9, then use titration in non-aqueous media:
Titrant is a solution of sodium methoxide in the presence of dimethylformamide (DMF). BTS indicator: color transition from yellow to blue. See phthalazole.
6. Argentometry (Mohr’s method only) – see phthalazole.
7. Physico-chemical methods of analysis
A. Photometry.
b. UV spectroscopy.
V. Refractometry.
g. Polarography.
Streptocidum (Streptocide)
p-Aminobenzenesulfamide.
Description
Solubility: Slightly soluble in water, easily in boiling water, in diluted HCl, solutions of caustic alkalis and acetone, difficult in alcohol.
Authenticity:
1. The drug gives characteristic reactions to primary aromatic amines.
2. The drug is heated, a violet-blue melt is formed and the smell of ammonia and aniline is felt (unlike other sulfonamide drugs).
1. When heated with alkali, an ammonia smell is observed:
2. When streptocide is exposed to oxidizing agents, for example hydrogen peroxide, and then iron III chloride, a red-violet color appears (the chemistry has not been fully studied, but apparently the amino group is somehow converted into an OH group, along which it goes reaction with ferric chloride).
Purity:
1. Melting point.
2. Acidity.
3. General acceptable impurities: chlorides, sulfates, organic impurities, sulfate ash and heavy metals.
1. Nitritometry. f=1
Storage: List B, in a well-closed container.
Application: streptocide is used to treat tonsillitis, erysipelas, cystitis, pyelitis, enterocolitis, for the prevention and treatment of wound infections and other infectious diseases.
Release form: powder; tablets of 0.3 and 0.5 g in a package of 10 pieces; 10% ointment; 5% liniment.
Streptocidum solubile (Streptocide soluble)
para-Sulfamido-benzolaminomethane-sodium sulfate.
Description: White crystalline powder.
Solubility: Soluble in water. Practically insoluble in organic solvents.
Authenticity:
1. Reactions to the primary aromatic amino group after hydrolysis.
2. Formation of aurine dye after hydrolysis with c.H 2 SO 4 (difference from streptocide):
3. The drug gives a characteristic reaction to Na +, unlike streptocide (colors the burner flame yellow).
1. Reaction with hydrogen peroxide and iron III chloride gives a cherry-red color.
Purity:
1. Transparency and color.
2. pH=4.0 - 5.0.
3. Weight loss during drying.
4. General acceptable impurities: chlorides, heavy metals.
5. A specific impurity - sodium sulfite, is determined by titration with a 0.01 M solution of I 2.
Quantification: Nitritometry after hydrolysis.
Storage: List B. In well-closed jars.
Application: indications for use are the same as for streptocide. Good solubility in water allows the drug to be used for parenteral use. Solutions can be administered subcutaneously, intramuscularly and intravenously.
Release form: powder.
Sulginum. Sulfaguanidine*. Sulgin
p-Aminobenzenesulfoguanidine.
Description: White fine crystalline powder
Solubility: Very little soluble in water and alkali solutions, little in alcohol, with diluted hydrochloric and nitric acids forms salts that are soluble in water.
Authenticity:
2. The drug is heated, a violet-red melt is formed and the smell of ammonia is felt (destruction of the guanidine residue):
Where R is the sulfanilic acid residue. This reaction combines sulgin with urosulfan, but distinguishes it from all other sulfonamide drugs.
3. To distinguish sulgin from urosulfan, shake sulgin with alkali and add 2 - 3 drops of phenolphthalein to the solution - the solution will turn red. Urosulfan does not give this reaction.
Purity:
1. Melting point.
2. Acidity.
3. Loss of weight during drying.
4. General acceptable impurities: chlorides, sulfates, organic impurities, sulfate ash and heavy metals.
Quantification: Nitritometry.
Storage
Application: prescribed orally for adults and children for acute, subacute and chronic bacterial dysentery, for colitis and enterocolitis with diarrhea. Also used for carriage of dysentery bacilli and bacilli typhoid fever, in preparation for operations on the large and small intestine.
Release form: powder; tablets of 0.5 g in a package of 10 pieces.
Aethazolum, Sulfaethidole* (Etazol)
2-(p-Aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole.
Description
Solubility: Practically insoluble in water; soluble in alcohol, easily in alkali solutions, slightly soluble in dilute acids.
Authenticity:
1. Gives reactions to primary aromatic amines.
2. A specific reaction is a test with salts of heavy metals: with a solution of copper sulfate, a grass-green precipitate is formed, turning black.
Purity:
1. Melting point.
2. Color of the solution.
3. Acidity.
4. General acceptable impurities: chlorides, sulfated ash and heavy metals, sulfates.
Quantification: Nitritometry.
Storage: List B. In a well-closed container.
Application: used for pneumonia, dysentery, pyelitis, cystitis, erysipelas, sore throat, peritonitis, wound infections.
Release form
Norsulfazolum, Sulfathiazole* (Norsulfazole)
2-(p-Aminobenzenesulfaido)-thiazole.
Description: White or white with a slightly yellowish tint, crystalline powder, odorless.
Solubility: Very little soluble in water, little in alcohol, soluble in diluted mineral acids and solutions of caustic and carbonic alkalis.
Authenticity:
2. When CuSO4 solution is added to the alkaline filtrate, a dirty precipitate is formed. purple(difference from other sulfa drugs)
3. The drug is heated in a dry test tube, a dark brown melt is formed and is felt pungent odor hydrogen sulfide (unlike other sulfonamide drugs, except phthalazole).
Purity:
1. Melting point.
2. Acidity.
3. General acceptable impurities: sulfates, chlorides, sulfate ash and heavy. Meh.
Quantification: Nitritometry.
Storage: List B. In a well-closed container.
Application: taken orally for pneumonia, meningitis, staphylococcal and streptococcal sepsis and other infectious diseases.
Release form: powder; tablets of 0.25 and 0.5 g in a package of 10 pieces.
Sulfadimezinum. Sulfadimidine* (Sulfadimezin)
2-(p-Aminobenzenesulfamido)-4,6-dimethyl pyrimidine.
Description: White or slightly yellowish crystalline powder.
Solubility: Practically insoluble in water, easily soluble in acids and alkalis.
Authenticity:
1. The drug gives a characteristic reaction to aromatic primary amines.
2. When a CuSO4 solution is added to the alkaline filtrate, a yellowish-auto-green precipitate is formed that quickly turns brown (unlike other sulfonamide drugs)
3. The drug gives a violet color with a solution of oxidized sodium nitroprusside (difference from other sulfonamide drugs).
Purity:
1.Melting point
2. Acidity.
3. Transparency and color of the solution.
4. General acceptable impurities: sulfates, sulfate ash and heavy metals, chlorides.
Quantification: Nitritometry.
Storage: List B. In a well-closed container, protected from light.
Application: for pneumococcal, streptococcal, meningococcal infections, sepsis, gonorrhea, as well as for infections caused by E. coli and other microorganisms.
Release form: powder; tablets of 0.25 and 0.5 g in a package of 10 pieces.
Phthalazolum, Phthalylsulfathiazole* (Phthalazole)
2-(p-Phthaliloaminobenzenesulfamido)-thiazole.
Description: White or white with a slightly yellowish tint powder.
Solubility: Practically insoluble in water, very slightly soluble in alcohol. Soluble in aqueous solution sodium carbonate.
Authenticity:
1. On the primary amino group after acid hydrolysis.
2. Add resorcinol and sulfuric acid and fuse in the flame of an alcohol lamp for 1-2 minutes. Then cool, dissolve in alkali, dilute with water. Green fluorescence (GF 10) is observed. This is a reaction to phthalic acid resulting from hydrolysis:
Purity:
Free phthalic acid– determined by adding phenolphthalein. The acidic properties of phthalic acid prevent the solution from turning pink.
Norsulfazole– determined nitritometrically (by the primary amino group). The content of norsulfazole should not exceed permissible limits.
Quantification:
1. (GF) Non-aqueous titration in DMF. Indicator: thymol blue. Titrant – NaOH mixture methyl alcohol and benzene (produces sodium methoxide). Titrate until a blue color appears.
2. (Not GF) Argentometry (using Mohr's method) - see phthalazole.
2AgNO 3 + K 2 CrO 4 à AgCrO 4 ¯ + 2KNO 3
2HNO 3 + Na 2 B 4 O 7 + 5H 2 O à 4H 3 BO 3 + 2NaNO 3
Application: for dysentery (acute and chronic in the acute stage), colitis, gastroenteritis, as well as for surgical interventions on the intestines to prevent purulent complications.
Storage: List B. In a well-closed container.
Salazodimethoxinum (Salazodimethoxin)
5-(p-phenylazo)-salicylic acid
Description: Brownish-orange, odorless, fine-crystalline powder.
Solubility: Practically insoluble in water, very slightly soluble in alcohol, easily soluble in sodium hydroxide solution.
Application: providing anti-inflammatory and antibacterial effect in the intestines.
Storage: List B. In a place protected from light.
Urosulfanum, Sulfacarbamid* (Urosulfan)
p-Aminobenzenesulfonylurea.
Description: White crystalline powder, odorless.
Solubility: Slightly soluble in water, slightly soluble in alcohol, easily soluble in diluted acids and solutions of caustic alkalis.
Authenticity:
1. General reactions to primary amines.
2. Heat with 1 ml of 5% sodium nitrite solution to a boil - ruby red color (specific reaction).
Quantification: nitritometry.
Application: Used for cystitis, pyelitis, cystopyelitis, pyelonephritis, infected hydronephrosis and other infections urinary tract. Most effective for pyelitis and cystitis without urinary disorders.
Storage: List B. In a well-closed container.
Sulfacylum-natrium, Sulfacetamidum natricum* (Sulfacylum-sodium)
p-Aminobenzenesulfacetamide sodium.
Description: White crystalline powder, odorless.
Solubility: Easily soluble in water, practically insoluble in alcohol.
Authenticity:
1. General reactions to primary aromatic amines.
2. Reaction of formation of copper salt. The sediment is bluish-green.
Quantification: nitritometry.
Application: The drug is effective against streptococcal, gonococcal, pneumococcal and coli-bacillary infections.
Storage: List B (except ointment). The powder is stored in a container protected from light; solutions and ointments - in a cool place, protected from light.
Salazopyridazinum, Salazodin* (Salazopyridazine)
5-(p-phenylazo)-salicylic acid.
Description: Fine crystalline orange powder.
Solubility: Salazopyridazine is practically insoluble in water, slightly soluble in alcohol, soluble in sodium hydroxide solution.
Authenticity:
Specific reaction(discoloration of salazopyridazine solution).
NORSULFAZOLE
norsulfazole(Norsulfazolum; PC, list B), an antibacterial agent from the sulfonamide group. White or white with a slightly yellowish tint, odorless crystalline powder. Very slightly soluble in water, slightly soluble in alcohol, soluble in diluted mineral acids, solutions of caustic and carbonic alkalis. For parenteral administration it is used norsulfazole sodium (soluble N. ) (Norsulfasolum-natrium; PC, list B), easily soluble in water. Effective against streptococci, meningococci, pneumococci, staphylococci and coli. Easily absorbed from the gastrointestinal tract and wound surface. Toxicity is low. Prescribed for postpartum septic complications, catarrhal bronchopneumonia, diplococcal septicemia of calves, necrobacteriosis, coccidiosis of chickens (with drinking water at 0.25% concentration). Oral doses: cow, horse 5.0 x 20.0 g; sheep, pig 1.0 x 5.0 g; dog 0.3 x 1.0 g; into a vein (norsulfazole sodium): cow 6.0 x 10.0 g; horses 8.0 x 12.0 g; sheep 1.5 x 2.0 g. Store in a well-closed container.
Veterinary encyclopedic dictionary. - M.: "Soviet Encyclopedia". Editor-in-Chief V.P. Shishkov. 1981 .
Synonyms:norsulfazole- norsulfazole... Spelling dictionary-reference book
NORSULFAZOLE- (Norsulfazolum). 2 (para Aminobenzenesulfamido) thiazole. Synonyms: Amidotiazol, Aseptosil, Azoseptale, Cibazol, Eleudron, Poliseptil, Pyrisulfon, Sulfathiazole, Sulphathiazolum, Thiazamide, etc. White or white with a slightly yellowish tint... ... Dictionary of medicines
norsulfazole- noun, number of synonyms: 1 medicine (1413) ASIS Dictionary of Synonyms. V.N. Trishin. 2013… Dictionary of synonyms
NORSULFAZOLE- Norsulfazolum. Synonyms: azoseptol, sulfathiazole, thiazamide, cibazole. Properties. White or slightly yellowish crystalline powder, poorly soluble in water and slightly soluble in alcohol. Release form. Available in powder and tablets of 0.25 and 0.5 g. Effective... Domestic veterinary drugs
Norsulfazole - medicine from the group of sulfonamide drugs (See Sulfonamide drugs). Used in tablets and powders in the treatment of infectious diseases (tonsillitis, pneumonia, dysentery, etc.) ... Great Soviet Encyclopedia
norsulfazole- norsulfazole, norsulfazoles, norsulfazole, norsulfazoles, norsulfazole, norsulfazolam, norsulfazole, norsulfazoles, norsulfazole, norsulfazoles, norsulfazole, norsulfazoles (
1. When assessing the quality of norsulfazole and streptocide in samples of several batches, the appearance did not meet the requirements of the ND in the “Description” section - the powders were wet and yellow in color. Give justification for the reasons for changes in their quality under this section in accordance with storage conditions and properties. Provide a set of tests to characterize the quality of norsulfazole and streptocide.
· Bring them chemical formulas, Latin and rational names, characterize the structure, justifying physical and chemical properties each of them (appearance, solubility in water, spectral characteristics) and the possibility of using them to assess the quality of a substance.
· Suggest group and differentiating reactions for their detection in drugs.
· Give methods for the quantitative determination of streptocide and norsulfazole.
Streptocide and norsulfazole are derivatives of n-aminobenzenesulfamide (sulfanilic acid amide). They differ in the character of R in the sulfamide group. They are acidic forms of sulfonamide and exhibit amphoteric properties:
Basic properties due to the aromatic NH 2 group (solubility in acids)
Acidic properties due to the H imide group (solubility in alkalis)
They are white or white with a slightly yellowish tint, odorless crystalline powders, streptocide - slightly, norsulfazole - very slightly soluble in water, soluble in alcohol, soluble in solutions of mineral acids, solutions of caustic and carbonated alkalis.
Tpl.str.=164-167° Tpl.norst.=198-203° (with unfolded)
Spectral characteristics:
1) Streptocide, 0.0008% solution in 0.01 M NaOH or lmax = 251 nm; 0.015% solution in 1M HCI lmax = 264, 271 nm, lmin = 241, 268 nm and shoulder from 257 to 261 nm.
2) Norsulfazole
Authenticity:
Based on qualitative reactions into functional groups.
1) Reaction caused by an aromatic amino group (general)
1.1 GF X reaction of azo dye formation
Azo dye (cherry red)
1.2 Condensation reaction
1.3 Oxidation reaction
2) Reaction of pyrolysis (thermal decomposition) of GF X
Streptocide forms a purple melt and ammonia is released
Norsulfazole forms a dark brown melt and there is a strong smell of hydrogen sulfide
Pb(CH 3 COO) 2 + H 2 S PbS ↓ + 2CH 3 COOH
3) Reaction caused by the sulfamide group (acidic properties, formation of complex salts).
According to GF X for norsulfazole, the reaction is different: a dirty purple precipitate is formed with CuSO 4.
Dirty fillet sediment
4) Reaction of the benzene ring (halogenation)
Quantification:
1) GF X nitritometry, based on the property of primary ar. amino groups form diazonium salts
feq =1 FPT
Ind tropeolin 00 (norsulfazole)
tropeolin 00 + m/blue (streptocide)
In t.eq. 2KBr + 2NaNO 2 + 4HCI Br 2 + 2NO + 2KCI + 2NaCI + 2H 2 O
|
Conditions – cooling (18°-20°, 0°-10°) so that diazonium salts do not decompose;
catalyst – KBr
2) UV spectrophotometry is possible, the concentration of a certain substance is based on a comparison of the absorption of the test substance with the absorption of RSO.
Cx = Cst×Dx / Dst
Solvent 0.1M NaOH or HCI; region l = 210-360nm
Storage: in a well-closed container.
Samples of several series did not meet the requirements of the RD in the “Description” section; the powders were wet and yellow, because storage conditions were not observed - they became damp in humid air and, having restorative properties due to the aromatic amino group, they oxidized to quinoneimide and turned yellow.
Procainamidi Hydrochloridum *
B-Diethylaminoethylamide n-aminobenzoic acid hydrochloride
C 13 H 21 N 3 O HC1 M. c. 271.79
Description. White or white with a slightly creamy tint crystalline powder, odorless.
Solubility. Very soluble in water, easily soluble in alcohol, slightly soluble in chloroform, practically insoluble in ether.
Storage. List B. In well-closed dark glass jars.
The highest single oral dose is 1.0 g.
The highest daily dose orally is 4.0 g.
The highest single dose into a vein is 1.0 g.
The highest daily dose into a vein is 3.0 g.
See also the article “Solutio Novocainamidi 10% pro injectionibus”.
Antiarrhythmic drug.
458. Norsulfazolum
Sulfathiazolum*
2- (n-Aminobenzenesulfamido)-thiazole
C 9 H 9 N 3 O 2 S 2 M.c. 255.32
Description. White or white with a slightly yellowish tint, odorless crystalline powder.
Solubility. Very slightly soluble in water, slightly soluble in alcohol, sparingly soluble in acetone, practically insoluble in ether, soluble in dilute mineral acids and solutions of caustic and carbonic alkalis.
Storage. List B. In a well-closed container.
Antibacterial agent.
460. Norsulfazolum- sodium
Norsulfazolum solubile
Norsulfazole soluble
Sulfathiazolum Natricum *
2- (n-Aminobenzenesulfamido)-thiazole-sodium
C 9 H 8 N 3 NaO 2 S 2 bH2O M. c. 385.39
Description. Lamellar, shiny, colorless or odorless crystals with a slightly yellowish tint.
Solubility. Easily soluble in water.
Storage. List B. In a container protected from moisture and light.
The highest single oral dose is 2.0 g.
The highest daily oral dose is 7.0 g.
Antibacterial agent.
488. Oxacillinum- sodium
Sodium salt of 3-phenyl-5-methyl-4-isoxazolyl-penicillin monohydrate
C l 9 H 18 N 3 NaO 5 S H 2 O M. c. 441.4
The content of the amount of penicillins in the preparation is not less than 90% and the content of C l 9 H 18 N 3 NaO 5 S H 2 0 is not less than 90%. Note. When determining activity by biological method, the total activity of the drug (sum of penicillins) must be at least 820 µg/mg(U/l(g) (page 943). Theoretical activity of oxacillin sodium salt monohydrate 909 mcg/mg. One microgram of chemically pure anhydrous oxacillin acid corresponds to a specific activity equal to one Action Unit (AU). The accuracy of the determination should be such that the confidence limits at P=95% deviate from the mean value by no more than ±5% (p. 963). The average value of the activity found must be at least 820 µg/mg(U/mg).
Description. White fine crystalline powder, bitter taste. Resistant in a slightly acidic environment and to the action of penicillinase.
Solubility. Easily soluble in water, slightly soluble in 95% alcohol, slightly soluble in chloroform, practically insoluble in acetone. ether and benzene.
Storage. List B. In a dry place, at room temperature. For doses see page 1028. Antibiotic.
486. Osarsollim
