Thank you
The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!
Papaverine(Latin - papaverine) is a widespread medicinal substance, which has antispasmodic, vasodilating and hypotensive effects. By origin and chemical structure, papaverine is alkaloid opium poppy, that is, it is obtained from poppy straw, but is not a narcotic substance.
Papaverine is both the trade name of some drugs and the international name (INN) of the active substance included in many drugs. Preparations with trade name"Papaverine" are one and the same with active substance"papaverine". This substance is called either simply papaverine, or papaverine hydrochloride. Moreover, papaverine hydrochloride is chemical name papaverine, and from the point of view of a doctor or patient there is no difference between these terms. Currently in countries former USSR medicinal products containing active component only papaverine is included, usually called simply “Papaverine”. In some cases, letters or abbreviations may be added to the word Papaverine, encoding the name of the drug manufacturer, for example, “Papaverine MS”, “Papaverine Bufus”, etc. However, in all cases we are talking about the same drug produced by different factories , but containing the active component papaverine.
In addition, there are multicomponent drugs with other names that simultaneously contain several active substances, including papaverine. These are drugs such as Papazol, Andipal, Theodibaverine, etc. However, in this article we will consider exclusively monocomponent drugs containing only papaverine as an active substance and having the same name accordingly. In order to distinguish and not confuse the active substance and the name of the drug, we will write the first with a small letter, and the second with a capital letter.
Monocomponent preparations containing only papaverine as an active substance are currently produced under the following commercial names:
Accordingly, the three dosage forms contain papaverine hydrochloride as an active substance in the following dosages:
Because pharmacological action papaverine is multidirectional, it is classified simultaneously into two groups of drugs, such as vasodilators (vasodilators) and antispasmodics. Accordingly, as an antispasmodic, Papaverine is used to treat functional disorders gastrointestinal tract, and as a vasodilator - in the treatment of erectile dysfunction.
Papaverine, by blocking the work of a number of enzymes, reduces the tone and relaxes the smooth muscles of all internal organs. The fact is that the internal organs (stomach, intestines, blood and lymphatic vessels, bronchi, lungs, urethra, etc.) are equipped exclusively with smooth muscles, due to the work of which their overall tone increases or decreases. When the tone increases, the organ contracts, that is, its spasm occurs, and when it decreases, on the contrary, relaxation and expansion of the existing lumen occurs. For example, when the tone increases smooth muscles intestines, bronchi or gall bladder, the organs are strongly compressed, characteristic spastic pains appear and the movement of contents through their lumens is disrupted. That is, the movement of the food bolus in the intestines is delayed, bile stops flowing from the gallbladder, and the required amount of air cannot pass through the bronchi. In addition, any spasm of internal organs is accompanied by pain of varying intensity. Papaverine relieves spasms, relaxes organs, thereby restoring their function and relieving pain. Since the drug is not selective, it effectively relieves spasm and pain of any internal organ, and therefore is used very widely. In principle, Papaverine has the same properties and therapeutic effects as the more widely known No-Shpa.
Papaverine has a relaxing effect only on internal organs, since it affects smooth muscles and does not affect striated muscles. The fact is that on the human body and in the heart there are only striated muscles, which have different properties and react to completely different stimuli and substances. Therefore, antispasmodics acting on smooth muscles do not affect the contractility of skeletal and cardiac muscles. Thus, Papaverine is able to relieve spasms and relax the muscles of internal organs without affecting the myocardium and body muscles.
Summarizing the described effects, we can highlight the following main therapeutic effects of Papaverine:
Papaverine is quickly absorbed into the bloodstream by any route of administration (tablets, rectal suppositories, intramuscular injections) and is excreted by the kidneys. Half of the administered dose of the drug is eliminated after 0.5 - 2 hours.
Papaverine tablets, injections and suppositories are indicated for use when the following diseases and states:
The tablets should be taken orally, swallowed whole, without chewing, biting or crushing in any other way, but with a sufficient amount of water (approximately 200 ml). Papaverine can be taken regardless of food, but as needed, that is, when spastic pain or painful spasms occur. However, if there are spastic pains in the organs of the gastrointestinal tract, then it is better to take Papaverine 15 - 30 minutes before meals, so that the drug relieves symptoms and the person can eat and drink calmly. For spasms and spastic pain of internal organs, adults and adolescents over 15 years of age are advised to take Papaverine 40–60 mg (1–1.5 tablets) 3–4 times a day. Children should be given tablets with a special pediatric dosage of 10 mg. Moreover, the dosage of Papaverine for children is determined by age:
The ampoules contain a sterile, ready-to-administer 2% solution of Papaverine, containing 20 mg of the active substance per 1 ml. Since the ampoule contains 2 ml of solution, the total dosage of Papaverine in the whole ampoule is 40 mg, which is equivalent to one adult tablet. The solution can be administered in its entirety subcutaneously or intramuscularly, and after dilution - intravenously. For adults and adolescents over 10 years of age, the solution is administered 2 to 4 times a day, and for children under 10 years of age – 2 times a day. A single dosage of Papaverine is determined by age:
For subcutaneous or intramuscular injection First of all, choose the injection site. It is optimal to inject the solution intramuscularly into the superolateral outer surface thighs or outer top part shoulder, and subcutaneously - into the area around the navel. Before performing the injection, the skin is wiped with an antiseptic, after which the required amount of solution is drawn into a syringe and injected into the prepared area. For intramuscular injection, the needle is inserted deep into the tissue perpendicular to the surface of the skin. And for subcutaneous injection first grab about 1 cm of skin with a large and index finger, making a fold out of it. After which the syringe needle is set at approximately an angle of 45 o to the surface of the skin and inserted into this fold. The solution is released into the tissue and the needle is carefully removed, after which the injection site is again wiped with an antiseptic. Each time, the solution should be injected into a point that is at least 1 cm away from other marks from previous injections.
For intravenous administration You must first dilute the required amount of Papaverine in 10 - 20 ml saline solution. Then this mixture is administered intravenously, slowly. Intravenous injections should be performed only in a hospital setting, and subcutaneous or intramuscular injections can be done at home independently if a person has mastered their technique and does not feel fear.
The suppositories are inserted into the rectum, gently pushing the index finger through anal hole. It is imperative to administer the suppositories with clean, freshly washed hands with soap or wearing sterile gloves. The dosage of suppositories for various diseases accompanied by spasms and spastic pain is determined by age and is 1 - 2 suppositories 2 - 3 times a day for adults, and 1 suppository 2 times a day for children over 10 years old. For children under 10 years of age, suppositories are cut into 2 or 4 equal parts and administered in these pieces containing the required amount of the active substance. Thus, children under 4 years old are given a quarter or half of a suppository, and from 5 to 10 years old - half a suppository 2 times a day. The maximum permissible single dosage of Papaverine is the highest dose indicated for each age, multiplied by four. That is, for an adult the maximum permissible single dosage is 60 * 4 = 240 mg, for a child from 10 to 14 years old - 20 * 4 = 80 mg, etc. Maximum permissible daily dosage equal to the maximum one-time multiplied by three.
If it is necessary to quickly achieve a therapeutic effect, especially in the first days of exacerbation of the disease, then injections should be used. After 2–3 days, if the person can swallow, the injections should be replaced with tablets or rectal suppositories. It is not recommended to carry out the entire course of therapy using subcutaneous or intramuscular injections, since this entails greater risks compared to taking pills. Therefore, injections should be given only if suppositories and tablets cannot be used for some reason. In general, doctors recommend following a simple rule when choosing the form of the drug - always use either suppositories or tablets, and use injections only when it is necessary to obtain a quick therapeutic effect, but at the first opportunity, replace them with tablets or suppositories.
If a person suffers from gastrointestinal spasms, then he can use Papaverine both in suppositories and in tablets, based solely on personal preferences. However, it should be remembered that when using Papaverine suppositories, the clinical effect occurs faster than with tablets. Therefore, if you need to get a quick effect, it is better to use candles. It is also recommended to choose suppositories if a person for some reason cannot swallow tablets.
For spastic pain in the organs of the urinary system, the best option is Papaverine suppositories, since when they are introduced into the rectum, the active substance very quickly reaches the affected tissues and has a powerful effect. therapeutic effect. If for some reason it is impossible or difficult to insert suppositories into the rectum, then they should be replaced with tablets.
In children, it is recommended to use Papaverine in the form of suppositories or special children's tablets with a low dosage of the active substance of 10 mg. Children should not be given halves or quarters of Papaverine tablets for adults, which contain 40 mg of the active substance.
Papaverine is not a drug intended for long-term course use, therefore it is used exclusively for one-time relief of spastic pain against the background of an exacerbation of a disease or condition. This means that Papaverine tablets, suppositories or injections can be used on their own for 2 to 3 days, after which an improvement must appear, expressed in a decrease in spastic pain and discomfort in the field of localization pathological process. If there is no improvement, you should immediately consult a doctor, as this may indicate the development of a severe surgical pathology, for example, appendicitis, bleeding, peritonitis, etc.
As prescribed by a doctor, Papaverine is usually used for 7 to 14 days or a little longer, until the painful spastic pain is completely relieved. If a person has been suffering for a long time from any chronic disease, for example, cholecystitis, then he knows perfectly well the symptoms of its exacerbation and the dynamics of improvements that occur while taking Papaverine, and therefore can independently determine the duration of taking the drug.
If a person encounters spastic pain for the first time, then the first course of therapy should be carried out exclusively under the supervision of a doctor and independently record their own sensations, as well as positive dynamics. In the future, when the disease worsens, spasms will also be relieved with antispasmodics, and their dynamics will not differ fundamentally from what was recorded the first time. And a person who well remembers the dynamics of reducing spastic pain and normalizing the condition, during periods of exacerbations in the future, will be able to independently control how correctly and well the treatment is going, without visiting a doctor or going to the hospital for this. In addition, he will be able to record any distinctive manifestations of the dynamics of treatment and report them to the doctor, who, in turn, will specifically look for their cause and deal with the problem of diagnosing combined or atypical pathology.
In addition, No-Shpa with Papaverine is often used to prepare the cervix for childbirth, for which women take 1 tablet or administer 1 suppository of each drug 2 times a day for 2 weeks before the expected date of birth. This practice is widespread, but these cervical preparation drugs do more harm than good, because just before childbirth, when the uterus should actively contract and prepare, it is artificially “slowed down” with antispasmodics, relaxing the muscles and reducing tone. As a result of using No-Shpa with Papaverine “to prepare the cervix,” the likelihood of weakness increases labor activity and, accordingly, the use of labor stimulation, labor induction and the application of obstetric forceps or vacuum. That is, it is not the preparation of the cervix that occurs, but the suppression of labor.
The use of No-Shpa with Papaverine does not reduce the risk of ruptures, which in most cases depend only on the competent management of labor by a doctor. And to prepare the cervix for childbirth, which is carried out only in cases of postmaturity or the need for urgent delivery against the background of a threat to the mother’s life, completely different drugs (Prostin, etc.) and non-drug agents (kelp, Foley catheter, etc.) are used.
In children of the first year of life, Papaverine is used mainly to relieve spastic pain and intestinal colic, and in older children - to relieve bronchospasm, as well as in the complex treatment of pancreatitis, hepatic colic and urethral spasms. In addition, if a child has a high fever and white, cold hands and feet, then Papaverine is given to dilate blood vessels 15 - 20 minutes before the antipyretic drug. In a situation where the hands and feet are cold and the temperature is very high, an antipyretic without first taking an antispasmodic (Papaverine, No-Shpy, Drotaverine, etc.) will not work, since the narrowed, spasmodic vessels will not give off excess heat and cool the body .
Papaverine in children is used in all three dosage forms in dosages depending on age:
Papaverine expands blood vessels and moderately reduces blood pressure, however, it is not used as a specific antihypertensive drug for long-term courses of treatment. Papaverine in combination with Dibazol is usually administered by injection during a hypertensive crisis Papaverine is an effective antispasmodic that is widely used in medical practice for various diseases. Papaverine suppositories are used for pathologies accompanied by spasm of the smooth muscles of hollow organs, for example, cholecystitis, renal colic, spastic colitis, bronchospasm, endarteritis, migraines and many other diseases. When administered rectally, the drug is quickly absorbed and its active components enter the bloodstream. The therapeutic effect occurs quite quickly.
Papaverine is available in several dosage forms. These are tablets, injection solution and rectal suppositories. Many experts claim that Papaverine suppositories are the safest form of release. One suppository contains 20 mg of the active ingredient – papaverine hydrochloride.
Papaverine hydrochloride suppositories, after administration into the rectum, affect smooth muscles bronchi, lungs, colon and small intestine, stomach, uterus. However, the effect of the drug does not apply to the muscles of the skeleton and heart. After the product enters the body, these muscles work as usual.
Properties of the drug:
During childbirth, women are prescribed Papaverine suppositories to relieve cervical hypertonicity. Many people are interested in how to administer the drug vaginally or rectally? Papaverine suppositories are administered into anus patient.
What is the medicine used for? Papaverine suppositories are used for many diseases that are accompanied by pain. The drug is widely used in gynecology, urology, and surgery.
Main indications:
Papaverine helps relieve spasms in various diseases
Papaverine suppositories have a positive effect on the gastrointestinal tract during constipation and help normalize stool. The drug effectively fights migraines. For bronchitis, the medicine relieves spasm from the bronchi and helps prevent swelling of the mucous membrane.
The therapeutic effect of Papaverine suppositories is ensured by suppressing the phosphodiesterase enzyme. Thanks to this, it is possible to relieve muscle spasms and relax muscle fibers. The medicine has an effect on the human genitourinary, digestive, and hepatobiliary systems, and also relieves vasospasm. The active component papaverine hydrochloride increases the lumen of blood vessels, thereby normalizing systemic blood pressure. After administration of the drug, its active component quickly penetrates the bloodstream. Papaverine hydrochloride is evenly distributed throughout the body, affecting the central nervous system.
Important! During use during pregnancy, the drug can penetrate the placenta to the fetus and enter milk during breastfeeding.
The instructions for use include a number of contraindications that must be taken into account when using the medicine. These include:
Papaverine is prescribed by a doctor who must study the patient’s medical history and exclude all possible contraindications.
Where to insert Papaverine and how often can it be done? Suppositories should be used only as prescribed by a doctor. Typically, adults are administered 20 - 40 mg of the drug 2-3 times throughout the day. Sometimes a specialist may adjust the dosage depending on the diagnosis. Considering the question of how long the drug takes to act, it should be noted that on average the effect occurs after 30 – 40 minutes. Sometimes you have to wait longer for results. This depends on the characteristics of the disease and the individual qualities of the body.
The suppository should be administered according to the instructions.
Increased uterine tone threatens premature birth. Papaverine suppositories help relieve spasms and relax smooth muscles. According to the doctor’s recommendation, a woman is given 2–3 suppositories throughout the day to improve the tone of the uterus. It is advisable for every pregnant woman to have home medicine cabinet This is a medicine, because when a spasm occurs, this drug will become an emergency aid. The drug should be used carefully during treatment with other vaginal and rectal suppositories.
Sometimes the medicine is used among women in labor during false contractions. During this period, the woman experiences pain in the uterus and lower back, but this condition is only a harbinger imminent birth. To make a woman feel better, suppositories can be prescribed.
For prostatitis, Papaverine helps eliminate pain and unpleasant pulling sensations. During the period of exacerbation, 1-2 suppositories are inserted into the anus. three times a day. Before starting treatment, it is important to make sure that you are not allergic to any of the components of the product.
How to place Papaverine suppositories for hemorrhoids? As with other diseases, suppositories are used rectally. The dosage for a particular patient is selected by the doctor, taking into account the characteristics of the course of the disease, the type and stage of the disease. Typically the dosage of medication is varicose veins veins in the anal area is 1 - 2 suppositories three times throughout the day. The duration of therapy depends on the achieved therapeutic effect.
Papaverine for children is used under the strict supervision of the attending physician. The instructions for use say that the medicine is prescribed to children over the age of 12, but in some cases a specialist may prescribe the medicine to a child under this age.
The drug should be used with caution among children
Negative phenomena associated with the use of suppositories are extremely rare. This is evidenced by numerous positive reviews patients and doctors who have tested the drug in practice. Sometimes during treatment with the product, minor itching and irritation occurs in the anal area. If the dose is greatly exceeded, the patient may experience the following complications:
Treatment of the complications described above consists of blood purification and symptomatic therapy sick.
Important! During development warning signs During therapy with Papaverine, you should stop taking the drug and immediately visit a doctor.
With the simultaneous use of Papaverine with antihypertensive drugs, the effect of the latter is enhanced. The antispasmodic effect of papaverine hydrochloride increases when taking barbiturates. The hypotensive effect of the drug increases with simultaneous administration with drugs such as tricyclic antidepressants, Quinidine, Procainamide, Reserpine.
When starting treatment with the drug, you should carefully study the instructions for use. It includes several special instructions which must be observed. These include:
In addition, if the patient is taking any other medications, be sure to inform the doctor.
Before starting treatment, it is important to read the instructions for the drug
How to replace Papaverine suppositories? Among the analogues of the drug, the following drugs can be distinguished:
You should take any of the analogues only after examination by a doctor.
Self-medication often causes serious negative consequences.
Papaverine suppositories are available from pharmacies with a doctor's prescription. It is recommended to store the medicine in a place where sunlight does not penetrate. Shelf life is 3 years, provided that the recommendations for storing the drug are followed. After this period, the product cannot be used.
Papaverine is an antispasmodic. The drug lowers blood pressure and relieves tension in the smooth muscles of internal organs. If you take a large dose of papaverine, you will feel a slight sedative effect and even your heart rate will become somewhat slower.
Do not self-medicate or use papaverine without a doctor's prescription. In addition to papaverine, for hypertonicity of the uterus, drugs containing vitamin B6 are also used, as well as magnesium, which relaxes the muscles very well. Magnesium, by the way, also effectively helps with leg cramps, which often torment pregnant women. Therefore, do not neglect dietary supplements (biologically active additives), containing vitamins and microelements. After consulting with your doctor, select medications that are designed specifically for pregnant women.
During pregnancy, a woman tries to protect herself from various kinds of negative influences and factors that can lead to complications. And this includes not only all kinds of diseases, but also disorders, experiences, as well as stressful situations that pose a threat to normal development baby and maintaining pregnancy. Unfortunately, it is not always possible to isolate yourself from stress, and sometimes situations arise that require medical care. Nervous tension and stress also cause anxiety in the baby, which is why he becomes mobile. Its movements cause the uterus to tense, increasing its tone, which can cause contractions and threaten the continuation of the pregnancy. In this case, in order to prevent negative consequences, the doctor may prescribe special drugs, one of which is suppositories with papaverine during pregnancy.
Papaverine suppositories or Papaverine hydrochloride belong to the antispasmodic group of drugs, the purpose of which is to relax smooth muscle cells. Its effect is on all systems and organs human body, which contain smooth muscles, including blood vessels. This particular drug is one of the few drugs that are so often used during pregnancy. Read more about pregnancy management→
Papaverine or Papaverine hydrochloride suppositories are administered rectally during pregnancy, but the drug does not have any effect negative impact on the fetus, but, on the contrary, helps to maintain pregnancy when there is a threat of termination, since it perfectly reduces the increased tone of the uterus and blood flow in the placental-uterine circle.
The main effect of the drug is aimed at:
The drug is available in three forms:
During pregnancy, the doctor may prescribe not only suppositories with papaverine, but also an injection solution. And here it is important to take into account one point: if appointed intravenous injections, then they should only be carried out in a hospital under the constant supervision of a doctor. This form of the drug should be administered very slowly. When prescribing subcutaneous or intramuscular injections treatment can be carried out at home.
Most often, during pregnancy, doctors prescribe suppositories with papaverine. This form of release is universal and quite convenient, which allows you to quickly reduce uterine hypertonicity to normal condition if necessary.
Overstrain of the uterus during the development of a baby in it can lead to miscarriage. early stages and premature births - at later ones. The uterine muscles cannot relax on their own. A child growing inside it constantly stretches its walls, which leads to severe tension.
Among the direct indications for the use of Papaverine in various forms can be noted:
During the period of nine months of bearing a baby, few women will not resort to the help of this drug at least once. Some reduce the increase in uterine tone regularly, while others use the product only occasionally, for example, after a hard day at work or being on their feet for a long time, as well as during periods of severe stress, in order to save themselves from possible problems and eliminate risks to the fetus.
The instructions for Papaverine suppositories during pregnancy say that there is no data indicating the effect of the drug on the body. At the same time, during clinical observations over many years of use of the product by pregnant women, no negative influence the fetus and the course of pregnancy were not established. Of course, you should not prescribe such a drug yourself, since only a specialist can correctly assess the condition female body and establish the need to use medicine.
Papaverine hydrochloride has a pronounced antispasmodic effect myotropic in nature, affecting not only the muscles of the uterus, but also the smooth muscles of many other organs, for example, the respiratory, urinary, and reproductive systems. The effect of the drug also extends to the gastrointestinal tract. By influencing the smooth muscles of blood vessels, the drug promotes their expansion, which significantly improves blood flow and reduces pressure. During pregnancy, Papaverine is most often used to eliminate spasms of many internal organs, peripheral and cerebral vessels, bronchi, uterine hypertonicity and improve placental blood flow.
The dosage of suppositories with papaverine during pregnancy is determined by the doctor, but in most cases suppositories should be administered 2 to 4 times a day, maintaining equal time intervals. The duration of treatment in each case will be individual, it depends on the symptoms and condition of the patient. On average, treatment can last from several days to a month, but sometimes longer.
Once in the rectum, the suppository begins to dissolve under the influence of body temperature, gradually releasing the medicinal substance, which is absorbed into the bloodstream and delivered circulatory system to all organs, affecting blood vessels along the way. Under the influence of the drug, the level of excitability of the uterine muscles is significantly reduced, painful sensations and voltage, at the same time decreases and blood pressure, which is necessary for many pregnant women later.
So, to the question of where to place suppositories with papaverine during pregnancy, every doctor will answer - in the rectum exclusively by the rectal method. Under no circumstances should they be used vaginally.
Each medicine has side effects, as well as prohibitions and restrictions on use. Taking into account the provision hypotensive effect, the drug should not be used by women with hypotension (low blood pressure).
The use of Papaverine suppositories during pregnancy is contraindicated in the following cases:
In some cases, suppositories can only be used with caution, and this category includes not only pregnancy, but also disruption of the adrenal glands, the functions of the pituitary gland, as well as hypothyroidism.
The use of Papaverine suppositories during the period deserves special attention. breastfeeding. To date, there is no reliable data on the effect of the substance on the baby during this period. However, doctors in many clinics and scientific centers It is not recommended to use suppositories during lactation. If there is an urgent need for their use, it is better to temporarily wean the baby (for the period of therapy) and resume feeding after treatment.
Despite the good healing effect and safety for the baby, it is not worth abusing the use of Papaverine suppositories.
The most commonly observed side effects are:
Despite the safety of Papaverine for the development of the fetus and the effective assistance of the drug in terms of maintaining pregnancy, you should not self-medicate.
Only a doctor should prescribe the use of Papaverine suppositories during pregnancy if there are indications for this drug and the need for its use. Therefore, if any symptoms of malaise, colic, uterine tension, or severe stressful situations, you must consult a doctor immediately. Suppositories with papaverine can significantly alleviate the condition of a pregnant woman if all the doctor’s recommendations on how to use the drug are followed. And when a woman knows where to insert suppositories with papaverine during pregnancy, this will help her quickly relieve tension in the uterus, which is a very important point.
The main component of the drug relaxes muscle fibers and reduces spasms. The medication affects the smooth muscles of various organs: stomach, large and small intestines, bronchi and lungs, blood vessels and uterus. Papaverine does not affect the muscles of the skeleton and heart, which work in the same mode after using the drug.
Suppositories help dilate arteries and lower blood pressure. The main component, which penetrates the bloodstream in small quantities, reduces the excitability of the heart muscle.
Dilates blood vessels, lowers blood pressure.
Improves blood supply to internal organs, including the uterus.
It has a calming effect and normalizes heart rhythm.
Suppositories with papaverine before childbirth are used to relax the muscles of the cervix.
Cholecystitis (inflammation of the mucous membrane of the gallbladder).
Diseases digestive tract(inflammation of the colon, increased gas formation, functional intestinal failure).
Urinary tract infections (inflammation of the urethra or bladder).
Late toxicosis is a complication that causes swelling, spasms, and high blood pressure.
Many people use suppositories with papaverine to speed up labor. In addition, the drug has a sedative effect and normalizes heart rhythm. However, such an effect is observed only as a result of long-term use of the drug.
Hypersensitivity to the active component or additional substances of the drug.
Constant or periodic increase in eye pressure.
Functional liver disorders.
AV block is a violation of the transmission of electrical impulses between the atrium and ventricle.
Defecation disorders (constipation);
Reduced blood pressure.
The drug is also prescribed to children and the elderly.
2. From the 13th week of pregnancy, the list of approved drugs increases. To reduce the tone of the uterus, more serious medical supplies(Ginipral, Bricanil, Magnesia, etc.), which relax smooth muscles. With the help of papaverine suppositories, pain and spasm are eliminated in the following diseases: renal colic, diseases of the digestive tract, and genitourinary system. The drug is also used to normalize blood pressure.
High uterine tone long before birth. Suppositories are taken together with steroid hormones.
Suppositories are used before childbirth to detect true contractions. If after insertion of the suppository the uterus continues to contract, it means that labor has already begun.
With the help of the drug, the uterus is prepared for the upcoming birth at 38–39 weeks. Suppositories soften the cervix.
Papaverine suppositories during childbirth reduce pain.
The duration of the therapeutic course depends on the symptoms, stage of pregnancy and is determined solely by the attending physician.
Use the drug under the supervision of a doctor for functional kidney and adrenal insufficiency, diseases thyroid gland, heart rhythm disturbances.
During treatment with suppositories with papaverine (as throughout the entire pregnancy), it is strictly forbidden to drink alcohol.
The decision to take Papaverine together with other medications is made by the attending physician.
The drug has a sedative effect, and therefore it is not recommended to take it before work that requires increased attention.
And they even prescribed me to put it on 2 times a day every day, starting from 4 weeks. They told me to put it on until 12 weeks, and then we’ll see.
women on baby.ru
Our pregnancy calendar reveals to you the features of all stages of pregnancy - an extremely important, exciting and new period of your life.
We will tell you what will happen to your future baby and you in each of the forty weeks.
Papaverine is a drug that is widely used in modern medicine. Due to the fact that there are several forms of release, it can be prescribed by a specialist to people with varying degrees of susceptibility. Indications for the use of Papaverine are different, so in hospitals, for example, injections are used, while at home you can use tablets or suppositories.
Papaverine belongs to the group of opioid alkaloids produced by synthesizing various components. Its main active ingredient is papaverine hydrochloride. The medication is available in three dosage forms:
Papaverine is a drug that can be found in any pharmacy
Papaverine hydrochloride inhibits the activity of an enzyme called phosphodiesterase, which in turn provokes the accumulation of cyclic adenosine monophosphate at the cellular level. After this, the level of calcium decreases and ultimately this leads to the fact that the smooth muscles relax, and the number of their contractions returns to normal.
The medication can relieve a person from spasms of the smooth muscles of the intestines, stomach and other organs of the digestive system, bronchi, uterus, kidneys, urinary and gall bladder. When exposed to the components of the drug, there is an exceptionally relaxing effect, elasticity and natural movements of all muscle groups are preserved in in full.
As mentioned earlier, Papaverine is an antispasmodic that also has a hypotensive and anticonvulsant effect. What is Papaverine used for:
After entering the body, the drug begins to be absorbed almost immediately; the maximum effect of Papaverine is achieved within half an hour. Excreted from the body through the kidneys.
Recommendation: if there is an emergency need to remove all components of the medication from the body, you can resort to dialysis. During this procedure, the blood is completely cleansed of toxins, as well as unnecessary and harmful substances.
The main indications for the use of Papaverine are muscle spasms which arise in the following cases:
Papaverine can also be used during surgery. It is administered by an anesthesiologist to reduce muscle tone in the airways. Thanks to this, it will be much easier for the patient’s body to tolerate anesthesia.
Papaverine affects smooth muscles, regulating their tone
The vast majority of pregnant women are faced with the phenomenon of uterine hypertonicity. This condition is considered quite dangerous because it can provoke premature birth. Even during attacks, blood flow to the fetus decreases, which entails negative consequences - the child simply does not receive all the necessary nutritional elements and substances. To reduce muscle tone, women are prescribed Papaverine, which can also lower blood pressure if it suddenly rises. Along with this, blood flow to the uterus improves, which has a positive effect on the development of the child.
One more positive property Papaverine is that it has a sedative effect. It relieves nervous tension, which is typical for many pregnant women, and it is this that, as is known, can provoke the development of uterine tone.
Important: you should take the antispasmodic Papaverine carefully during pregnancy; if you have the slightest suspicion of worsening your condition, you should stop taking it and consult a doctor.
A number of side effects are possible:
A completely logical question that arises in many women is where, in fact, to insert suppositories (if this particular dosage form was prescribed), if they are intended for rectal administration, but is it necessary to provide a therapeutic effect in the genitourinary system? The answer is simple - where indicated, since the active components are quickly absorbed into the bloodstream and are first distributed locally to nearby organs, and then further throughout the body. This ensures that the smooth muscles of the uterus will be saturated with the substances of the drug in full and in a short time.
Papaverine is often prescribed during pregnancy because it can alleviate a woman’s condition.
In order to avoid the appearance and development of allergic reactions, you should not take Papaverine if you have an individual intolerance to active substance or other components of the drug. Medication treatment should be interrupted immediately if signs of allergy are detected. The instructions for the medicine state that the contraindications for Papaverine are as follows, and it is prohibited to take it:
Papaverine should be taken with extreme caution by those diagnosed with:
It is possible to develop atrioventricular block, a condition in which the electrical impulse between the ventricles and atria slows down or stops altogether. This leads to heart rhythm disturbances. Along with this, a decrease in blood pressure and ventricular tachycardia is possible.
Here are the possible:
To everyone else side effects Papaverine includes allergic reactions, excessive sleepiness and eosinophilia - an increase in the blood level of special cells responsible for fighting toxins and various microorganisms.
It should be remembered that side effects themselves develop extremely rarely. They can appear only in cases where a person began taking Papaverine independently and without consulting a specialist, or when he significantly exceeded the dosage recommended by the doctor.
The information in the article is for informational purposes only; self-medication is not recommended. Only a doctor should prescribe Papaverine and select the dosage.
Update: October 2018
Papaverine – antispasmodic medicinal product, which is actively used to reduce the contractile function of smooth muscle fibers and reduce muscle tone, which leads to rapid relaxation of smooth muscles. It is a derivative of opioid alkaloids and is produced by synthesis.
Prescribed to eliminate spasms of the biliary tract, ureters, gastrointestinal tract, and decrease the tone of the uterus. Used as a vasodilator for the coronary circulatory system for subarachnoid hemorrhages and coronary bypass surgery, as well as in a number of other cases.
Pharmgroup: myotropic antispasmodics.
Available in three forms: rectal suppositories (suppositories), tablets, solution for injection.
| Pills | Solution 2% (Papaverine in ampoules) | Suppositories | |
| Main substance | 10 or 40 mg of papaverine hydrochloride in 1 tablet. | 20 mg of papaverine hydrochloride in 1 ml of solution - 2 ml of solution in 1 ampoule | 20 mg papaverine hydrochloride |
| Excipients | Sugar, starch, stearic acid, talc | Edetate disodium, L-methionine, water for | Semi-synthetic glycerides up to 2 g |
| Physico-chemical properties | White tablets with two perpendicularly located marks dividing the tablet into 4 equal parts |
Clear solution, colorless or slightly yellowish |
Torpedo-shaped suppositories, solid. White. Odorless. |
| Package | 10 pcs. in contour cell blisters. In cardboard packs of 1-3 blisters |
5 or 10 ampoules in cardboard packages |
5 suppositories in polyethylene blisters. 2 blisters per cardboard package |
| Price | 40 mg No. 10 – 10-40 rub. | No. 10 – 35-50 rub. | No. 10 – 35-70 rub. |
Papaverine hydrochloride is an inhibitor (inhibiting) of the phosphodiesterase enzyme and leads to the accumulation of cyclic 3,5-adenosine monophosphate, a decrease in calcium levels inside cells, which causes impaired contractility of muscle fibers and relaxation of the smooth muscle structures of internal organs and blood vessels. In average therapeutic doses it has no effect on the central nervous system. In high doses leads to a decrease in excitability muscle tissue heart and slows down the speed of intracardiac conduction. A special feature of the drug is the absence of a paralytic effect - the muscles only relax, while their movements and functions are completely preserved.
In addition to the antispasmodic effect, the drug has a moderate local analgesic effect and is characterized by minor hypotensive and sedative properties.
Completely and quickly absorbed, binds to plasma proteins by 90%. Penetrates through the blood-brain barrier and into all tissues. Undergoes biotransformation in the liver. The half-life ranges from 0.5-2 hours. Excreted by the kidneys in the form of metabolites.
Prescribed as an auxiliary drug for premedication before surgical interventions on the gastrointestinal tract, proctological and urological procedures.
Suppositories with Papaverine during pregnancy are quite often prescribed by doctors. The main reason for prescribing the drug is uterine hypertonicity, which is known to be one of the causes of miscarriage (Papaverine is especially often prescribed in the early stages of pregnancy), as well as. Since the uterus is a muscular organ, the drug is prescribed to relax it, very often in combination with hormonal drugs.
In combination with No-Shpa, Papaverine is prescribed in late stages of pregnancy to prepare the cervix for labor. However, many obstetrician-gynecologists are against such preparation, since it leads to artificial inhibition of uterine contractility and.
The instructions for Papaverine note that the effect of the drug during pregnancy and lactation has not been studied, so it cannot be stated about its safety. This means that the appointment can only be made by a doctor, after weighing possible benefit and risks. How much and how to take Papaverine, the attending physician must say; self-medication is unacceptable.
In children under one year of age, the main indication for treatment is spastic pain in the gastrointestinal tract and intestinal colic. For older children it is prescribed to relieve bronchospasm, urethral spasms, and hepatic colic.
Another area of application is the relief of peripheral vascular spasms due to hyperthermia: Papaverine is given 20 minutes before the antipyretic.
During treatment, an increase in the activity of liver transaminases and development is likely. Eosinophilia is possible.
With rapid intravenous administration or when prescribed in high doses, AV block may develop. Thrombosis is possible at the injection site.
The dosage of Papaverine differs for different dosage forms and different age groups.
Use of Papaverine tablets for younger children age group should be carried out after preliminary dissolution in water.
Enter rectally. The suppository can be cut.
The drug can be administered subcutaneously, intravenously and intramuscularly. IV administration is carried out slowly, monitoring heart function, especially in patients with stenosing coronary sclerosis.
Visual impairment, weakness, redness of the skin, dry mouth, arterial hypotension, constipation, ataxia, asystole, tachycardia, ventricular flutter, collapse.
There is no specific antidote, so it is organized symptomatic treatment, and in severe cases - hemodialysis.
Since smoking reduces the effectiveness of papaverine, you should give up the habit at least for the duration of treatment. Also, you should not drink alcohol together with Papaverine (it potentiates the effect of alcohol).
During therapy, you should avoid work and activities where reaction speed is important.
For elderly patients, patients with head injury, chronic renal failure, supraventricular tachycardia, decompensated, diseases endocrine system, at states of shock the initial dose is set below the average therapeutic dose, most often no more than 10 mg (or 0.5 ml of a 2% solution).
Papaverine bufus, Papaverine hydrochloride MS, Papavin.
