The drug Amoxiclav - reviews of doctors and adults on the use of the drug
The abstract provides information that the antibiotic Amoxiclav (INN Amoksiklav) is a drug wide range impact. Group of antibiotics: broad-spectrum penicillins. Latin name: Amoksiklav. Manufacturer: Sandoz (Austria)
Doctors about Amoxiclav: how to take it, during pregnancy, for children, while breastfeeding, for sinusitis.
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An effective antibiotic.
Doctors of many specialties prescribe an effective and reliable antibacterial (antimicrobial) drug - Amoxiclav. Which includes Amoxicillin, semi-synthetic penicillin - a broad-spectrum antibiotic and clavulanic acid. The drug is produced in the form of tablets and suspension. It is a reliable antibiotic of choice for inflammatory bacterial infections. Country of origin: Switzerland. Amoxiclav is prescribed for inflammatory diseases of the upper and lower respiratory tract, diseases of the genitourinary system, infections of the skin and musculoskeletal system, as well as inflammation of the biliary tract (cholicystitis, cholangitis). The drug can only be prescribed by the attending physician.
Doctor's assessment:
2018-05-02 19:23:03
An effective drug with a wide spectrum of action
Amoxiclav is a combination drug. It contains amoxicillin (directly an antibiotic) and clavulanic acid.
This drug has gained quite a lot of popularity, and this is no coincidence: it effectively fights a large number of pathologies, ranging from diseases of the upper and lower respiratory tract to pathologies of the urinary system.
Tablets are most often used, but they are quite large size, but crushing them is not recommended. In this case, it is better to immediately purchase the Quiktab form - such tablets dissolve easily in water. For children, you can use the solution to make a suspension.
From side effects When taking this drug, allergies, diarrhea and thrush in women are most often observed. To reduce the risk of diarrhea, you can take the drug Linex, which restores intestinal flora, in parallel or after the course.
Doctor's assessment:
2017-11-09 22:47:22
Amoxiclav - semi-synthetic penicillin
Amoxiclav - combined antibacterial drug, which contains amoxicillin and clavulanic acid. Amoxiclav provides bactericidal effect, damages the cell wall of bacteria, leading to their death.
The drug is widely used to treat diseases of the ENT organs caused by bacterial infections (sinusitis, frontal sinusitis, otitis media, tonsillitis); for inflammatory processes of the lower respiratory tract (bronchitis, pneumonia). Amoxiclav is also used to prevent infections after surgery.
Amoxiclav is available in several forms: film-coated tablets; powder for preparing a suspension; powder for preparing a solution for intravenous administration; dispersible tablets.
Amoxiclav suspension is used for children from the neonatal period, taking into account age and body weight.
Film-coated tablets are sufficient large sizes, so some patients have trouble swallowing the tablet. As an alternative to this form of release, there are Amoxiclav Quiktab dispersible tablets, which just need to be dissolved in half a glass of water and drunk.
It is advisable to take Amoxiclav orally before or during meals. This will minimize the occurrence of antibiotic-associated diarrhea.
Doctor's assessment:
2017-08-20 18:48:53
Amoxiclav in pediatrics
Amoxiclav is combined agent based on Amoxicillin and Clavulanic acid.
The need for the combination is due to the fact that over time, many bacteria have developed natural protection against Amoxicillin. The bacteria began to produce beta-lactamases. To overcome the high resistance caused by the binding and neutralization of Amoxicillin by the beta-lactamase of bacteria, Amoxiclav contains this acid. Clavulanic acid “distracts the attention” of the bacteria so that Amoxicillin can work at full strength.
Amoxiclav is widely used in pediatrics. This drug is very effective against many infections. Most often I use it for respiratory infections.
The various forms of release of Amoxiclav allow you to prescribe the most of different ages. According to official instructions In terms of use, it can be used from 3 months of age.
Thus, Amoxiclav is more effective than drugs containing unprotected Amoxicillin. Suitable for children of any age. However, clavulanic acid may enhance intestinal dysbiosis during therapy. Therefore, after taking Amoxialav, restoration of the microflora is necessary.
Doctor's assessment:
Amoxiclav is available in the following options- powder for solution for intravenous use, powder for suspension, tablets and soluble tablets.
Preparation good quality, time-tested. I use it quite often in practice, it is effective in the treatment of diseases of the pelvic organs (metroendometritis, salpingoophoritis, hydro-, pyosalpinx), as a prevention of purulent-septic complications in the preoperative and early postoperative period. It can be prescribed to pregnant women for the treatment of pyelonephritis (according to strict indications, if the expected benefit to the mother outweighs the potential risk to the fetus). It is well tolerated by patients, has a convenient dosage regimen, and side effects are quite rare.
The entire world around us is teeming with pathogenic microorganisms. Fortunately, every person’s body has one very pleasant feature. If everything is in order with the immune system, the skin and mucous membranes are not damaged, there is no need to be afraid of bacterial or any other infection. Otherwise, you will have to find out what amoxiclav is, what it helps with, and when this drug is prescribed.
Normal microflora is constantly present in the human body, but sometimes it can be replaced pathogenic flora and opportunistic, capable of leading to the development of disease.
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Normal |
Pathogenic |
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It begins to populate the child’s body from the first minutes of life, from the moment the baby is laid on the mother’s stomach. |
Constantly present in environment, penetrates, as a rule, into a weakened body. |
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Is part of immune system body, ensures normal digestion. |
It actively multiplies and releases toxins that can cause headaches. |
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In its absence, a diagnosis is made and therapy is carried out aimed at populating the internal environment with microbes. |
In addition to intoxication, pathogenic microflora leads to the development of infectious diseases. |
So it is necessary to fight only those microorganisms that can cause serious illnesses.Destruction normal microflora will lead to weakening of the body, digestive disorders and increased risk penetration of harmful microbes.
Since the drug is a drug, its prescription and use should be monitored by the attending physician:
Price varies depending on the dosage and form of the drug. If we take into account the tablets:
The antibiotic is sold in packages of 10-15 tablets, so by multiplying it is easy to calculate the price per battery or for the entire pack.
You shouldn’t skimp on your health, but sometimes you can get the same effect by paying significantly less. With a long course of treatment this is important, and in general, there is no point in overpaying and “donating” money to a pharmaceutical concern.
You can use by other means, produced, by the way, in Russia:
All listed drugs can effectively fight infection. Experts prefer to prescribe each of them as a choice for a specific localization of the infectious process. Therefore, it is better to stock up on a list of cheaper analogues even before going to the doctor and already in the office to ask why the better ones are not suitable for you. cheap drugs. Some health workers receive a percentage of the sales of expensive drugs, but all countries are trying to combat this practice.
Despite the fact that the listed funds cost less, they still remain strong antibiotics, the use of which must be approached “wisely”. The dosage of each drug is indicated in the instructions; you can consult a pharmacist at the pharmacy checkout.
During pregnancy, a woman is not protected from any disease, including bacterial infection. The only problem is that:
From the entire list of antibiotics, as a result of long observations, a small number of drugs were identified that can be used even in such a delicate situation. Among them was amoxiclav, but this does not mean that the tablets can be swallowed for any reason.
Antibiotic still affects the child and can lead to dire consequences, therefore, when prescribing, the doctor asks only one question: What will be more harmful for the mother and child - an untreated disease or the effect of amoxiclav?
Guided by the principle of less harm, the doctor tries to preserve the life and health of the mother, even if this causes serious harm to the baby.
Amoxiclav, like any antibiotic, is prescribed for bacterial infections:
Pathogenic microorganisms can infect genitourinary system, gastrointestinal tract, bone tissue. After examination by an appropriate specialist, the patient will be prescribed a full course of therapy, which will include antibacterial agent.
Each doctor has his own approach, but amoxiclav is used quite often; it is indicated in the treatment algorithm for many bacterial diseases.
You can find the drug in any pharmacy, By quite reasonable price, use with caution during pregnancy, breastfeeding and childhood. If the immune system cannot cope with a sudden “invasion” on its own, it is necessary to provide it with all possible assistance.
In this video famous doctor Komarovsky will tell you what he thinks about antibiotics and their use, what amoxiclav can help with and how to take it correctly:
Amoxiclav (Amoksiklav) belongs to antibiotics and is very widely used by specialists for various diseases. This drug is preferred for the treatment of sore throat, sinusitis, otitis media, bronchitis, skin infections and urinary tract, cholecystitis, pneumonia, infections of bones and joints.
Amoxiclav tablets:
Amoxiclav powder:
Amoxiclav injection solution:
Clavulanic acid provides a stable inactivated complex with these enzymes and ensures amoxicillin's resistance to the effects of beta-lactamases produced by microscopic organisms. This acid, the structure of which is similar to antibiotics of the beta-lactam type.
The action of Amoxiclav is effective against bacteria that are vulnerable to its effects. The symbiosis of amoxicillin and clavulanic acid is very unique. The use of an antibiotic leads to the death of bacterial cells by binding them together with surface receptors. The bacteria on which its influence is directed begin to get used and destroy this remedy through the enzyme Beta-lactamase. Clavulanic acid helps reduce the energy of this enzyme. This has led to the fact that Amoxiclav, which contains this unique acid, is used in various fields of medicine.
The instructions note that the combination of amoxicillin and clavulanic acid destroys bacterial strains resistant to amoxicillin. Amoxiclav is endowed with pronounced bacteriostatic and bactericidal properties against all streptococci, echinococcus and listeria.
According to the instructions, the medicine must be taken for the following infectious diseases:
Amoxiclav is used for complications that appear in postoperative period surgical intervention on the abdominal organs:
For surgical prophylaxis:
According to the instructions, Amoxiclav has the following side effects:
If side effects occur while using an antibiotic, you should immediately consult a doctor to replace the antibiotic with a similar one that does not cause side effects. Otherwise, irreversible processes may occur in the human body that can lead to death.
Amoxiclav may cause side effects affecting different systems and human organs, and they are expressed as follows:
Gastrointestinal tract. Impaired digestion and synthesis of certain vitamins (B and K) - bloating, lack of appetite, urge to feel sick and nausea itself, inconsistent stool, alternating diarrhea with constipation. The stomach suffers from side effects, 12 duodenum, gallbladder and the pancreas.
Liver. Liver dysfunction and sometimes cause drug-induced jaundice.
Kidneys. The drug has a toxic effect on kidney function, which leads to inflammatory processes in them and the formation of stones in the tracts that remove urine.
Central nervous system. Amoxiclav can cause constant headaches, dizziness, tremors and convulsions are possible when using the medicine.
Circulatory system. Blocks the synthesis of leukocytes, as a result, immunity decreases. And when platelet synthesis is suppressed, blood clotting decreases and bleeding occurs. Also, red blood cells under its influence can stick together, which leads to severe hemolytic anemia.
Allergic reactions. Urticaria, Quincke's edema. But such reactions occur quite rarely.
Amoxiclav should be taken immediately after meals. For mild or moderate forms infectious disease The rate of use is 375 milligrams (1 tablet) every 8 hours, or 625 (1 tablet) milligrams every 12 hours. Patients with severe disease or infection respiratory system, prescribe 625 (1 tablet) milligrams every 8 hours, or 1000 (1 tablet) milligrams every 12 hours.
Maximum daily norm taking the product should not exceed 6 grams. The duration of treatment is no more than two weeks. After completing the treatment course, you do not need to see a doctor for a re-examination. Odontogenic infection - 375 (1 tablet) milligram every 8 hours, or 625 (1 tablet) milligram every 12 hours. The course of taking the medicine is 5 days.
Kidney failure medium shape severity – 625 milligrams (1 tablet) every 12 hours. Severe renal failure - 625 milligrams (1 tablet) every 24 hours. Anuria - the medication dosage interval is 48 hours or more.
Amoxiclav tablets:
Before use, the tablet must be removed from the blister and dissolved in water. Half a glass of chilled water is enough boiled water. Or, when taking it, you can chew it and wash it down with water. You should not drink carbonated water, as carbonated water negatively affects the body’s perception of this antibiotic, which greatly reduces its effectiveness.
Amoxiclav in ampoules:
In cases where Amoxiclav tablets do not give the expected effect, or it is necessary to cure the patient in a shorter time, this drug is prescribed medicine in the form of intravenous injections.
An intravenous infusion of the antibiotic Amoxiclav is given into a vein located in the area elbow joint. When administering the medicine, care must be taken to ensure that it does not get under the skin. Otherwise, various allergic reactions. The drug must be administered slowly over 30-60 minutes. The one-time consumption rate is 1.2 grams. The interval between injections is 8 hours.
Amoxiclav for children
The pediatrician sets the dose rate for each child personally, and it depends on the severity of the disease and the location of the infection. When prescribing, sensitivity to the drug, age and the state of his health are taken into account. It is very important to strictly follow the dosage prescribed by your doctor.
It is recommended that Amoxiclav be taken by children under 12 years of age in the form of:
It is taken orally three times every 24 hours.
The one-time dosage depends on the age of the child:
In case of severe disease, the norm must be doubled.
Water is used to prepare the suspension, syrup and drops.
Amoxiclav should be taken with water, milk or fruit juices. Children should swallow the tablet whole without chewing it.
If a child suffers from gastritis or various stomach disorders, then the antibiotic should be taken with food.
During pregnancy and lactation
The use of Amoxiclav during pregnancy and breastfeeding is possible, but only in cases where the expected effect outweighs the possible risk.
Domestic pharmacies sell medications whose actions are similar to Amoxiclav. These include:
All these medications have been tested in domestic laboratories and approved by the Russian Ministry of Health. Their cost is low and they are available to everyone.
The price of Amoxiclav in different pharmacies may vary significantly. This is due to the use of cheaper components and the pricing policy of the pharmacy chain.
Read the official information about the drug Amoxiclav, the instructions for use of which include general information and treatment plan. The text is provided for informational purposes only and cannot serve as a substitute for medical advice.
– a drug that is prescribed for many infectious diseases, as well as for their prevention. This medicine is an antibiotic, therefore it requires caution in use - it must be taken strictly as prescribed by the doctor, observing the prescribed duration of the course of treatment.
Amoxiclav contains two main components - amoxicillin and clavulanic acid. Chemically they do not interact with each other. The main form of release is tablets, but Amoxiclav is available in solution for injection (intramuscular and intravenous). The drug belongs to antibiotics, a group of protected synthetic penicillins.
Amoxicillin is an antibiotic, a synthetic analogue of penicillin. Its spectrum of action includes staphylococci, streptococci, as well as a number of pathogens of other infections - whooping cough, brucellosis, especially dangerous infections, but in practice this effect is quite weak. Amoxicillin is included in the reserve regimen for the eradication of Helicobacter (a bacterium that is the causative agent of gastritis and peptic ulcer stomach).
One of the important advantages of amoxicillin is its low frequency side effects.
Penicillin and its analogues are considered the most safe antibiotics. This is due to the fact that their target - the bacterial cell wall - is completely absent in the cells human body. The toxicity of this drug for humans is extremely low, so amoxicillin is considered a safe drug.
However, it has a significant drawback. A number of bacteria (mostly) produce the enzyme penicillinase, which destroys the antibiotic. Amoxicillin, like other antibiotics penicillin series, is susceptible to the action of this enzyme. In order to protect the antibiotic from the effects of the enzyme, clavulanic acid, or more precisely, the sodium compound clavulanate, is used. It neutralizes penicillinase, which reduces the risk of bacterial resistance and increases the effectiveness of the drug. Therefore, the appointment of Amoxiclav is preferable compared to unprotected penicillins - amoxicillin, penicillin, and others.
The drug is prescribed for bacterial infections caused by microorganisms sensitive to it. To determine sensitivity, a bacteriological analysis and an antibiotic sensitivity test (antibioticogram) are performed.
In some cases, when in serious condition patient or high risk complications, it is permissible to prescribe Amoxiclav until the test results are received. In this case, the material for research must be taken before the start of treatment.
Infections for which Amoxiclav is prescribed:
Amoxiclav can also be prescribed after surgical interventions to prevent infectious complications, as well as for injuries if they were infected (contaminated with earth or other substances). For human and animal bites, this remedy is effective against infections in the oral cavity.
At nosocomial infections Amoxiclav is most often ineffective, since hospital microorganisms are most often resistant to the most commonly used antibiotics, including various types of penicillins.
The drug is available in several dosage forms, and each of them should be taken in accordance with the instructions. The tablets are taken orally, the dosage depends on the disease, the patient’s body weight, and the characteristics of the disease. For adults, the dosage is usually 250 mg every 8 hours or 500 mg every 12 hours. Adolescents over 12 years of age or weighing more than 40 kg take the medicine at adult dosage. For severe infections, the dose may be increased.
For children under 12 years of age, a suspension made from powder is preferred. It is also taken orally, but the dosage of the active substance is lower, which reduces the risk of side effects, especially allergic reactions. Daily dosage 40 mg in 3 doses. The drug is intended for children under 12 years of age or weighing less than 40 kg.
Injectable forms of the drug are intended for the treatment of severe infectious diseases; the exact dosage is prescribed by the doctor, and it can vary significantly depending on the patient’s condition. They may also be prescribed if oral administration of the medication is not possible ( serious illnesses stomach, intestines).
The duration of treatment ranges from 5 to 14 days.
It is impossible to shorten the course - this leads to the selection of resistant strains of bacteria. Even if the symptoms of the disease quickly disappear, the course of treatment must be completed. If after 14 days of taking the disease the disease is not cured, this indicates that the drug is ineffective and needs to be replaced with more effective means. As a rule, replacement occurs earlier.
The drug quite often causes hypersensitivity and allergic reactions, especially in children younger age whose immune system has not yet matured enough to adequate reaction for amoxicillin.
In addition to allergies to Amoxiclav itself, there are cross reactions hypersensitivity to penicillin antibiotics, as well as cephalosporins and other beta-lactams.
This is a fairly large and common group of antibiotics, an allergic reaction to one of the drugs in which may mean the presence of hypersensitivity to all related drugs. All such phenomena in the anamnesis are contraindications to the use of Amoxiclav.
It should also not be taken with various lesions liver - hepatitis, including drug-induced, phenomena of bile stagnation. These phenomena may be associated with taking Amoxiclav and be temporary; in this case, it is necessary to stop taking the drug and replace the drug with an analogue that does not have a hepatotoxic effect.
The third group of contraindications are severe pathologies of the immune system, in particular infectious mononucleosis and various types leukemia.
In these cases, taking antibiotics can further deteriorate the immune system and worsen the patient's condition.You should take the medicine with caution in case of renal failure and phenylketonuria in adults. Tablets are contraindicated for children under 12 years of age; injections are allowed only in severe cases when there is a danger to life.
Improper use of the drug may cause side effects
Dosage forms, which are intended for oral administration, may cause malfunction digestive system– loss of appetite, abdominal pain, diarrhea, nausea, vomiting and any other manifestations of dyspepsia.
If they are so strong that they make it impossible to take the drug, you should discard Amoxiclav and replace it with other drugs or injectable forms.
In turn injection forms can cause inflammatory reactions at the injection site, the formation of infiltrates under the skin, pain, swelling and others unpleasant phenomena. It's also possible dangerous complication– phlebitis (with intravenous administration).
Regardless of the dosage form, allergic reactions, a decrease in the number of leukocytes and a decrease in immunity as a consequence are possible. To combat this, it is advisable to combine the drug with measures to strengthen the immune system - taking vitamins, increasing the proportion of fruits in the diet.
Also possible headache, dizziness, convulsions, especially in patients with impaired renal function.
In children, the drug can cause increased excitability, nervousness, and moodiness. This is a temporary phenomenon that goes away fairly quickly. It does not pose a danger to the health and development of the baby.
The active substances penetrate the placental barrier and into breast milk, That's why this drug It is not advisable to take during pregnancy and breastfeeding. However, the presence of an untreated infection in the mother’s body is much more more dangerous than use antibiotics. The question of whether you need to take the medicine is decided only by your doctor.
Hello friends! Today I will tell you about the indications for use of amoxiclav, as well as what forms and dosages of this drug can be given to children.
In the previous article I talked about its composition and its analogues.
Now that we know the mechanism of its action, let’s figure out which diseases it is most effective for.
Amoxiclav indications for use
If you remember, in the last article I said that this medicine is unique. The uniqueness lies in the fact that the enzymes that bacteria secrete to protect against medications are not able to destroy its active substance.
This is what allows it to be used for a wide variety of diseases. And its property of being harmoniously distributed in the tissues of the body is suitable for combating pathogens living in a variety of places.
Here are the indications for use of amoxiclav by doctors:
1.Upper respiratory tract infections:
2. Infections of the genitourinary system:
3. Gynecological diseases:
4. Biliary tract infections:
5.Venereal diseases:
At the same time, the medication has indications for use in the fight against infectious agents developing in various tissues (bone, connective, muscle, mucous).
What do the indications for amoxiclav use say about the dosage?
The method of application and its dosage differ in each individual case. The severity of the disease, the patient’s age, the condition of the liver and kidneys, and anthropometric data are taken into account.
Also, the indications for use indicate that the usual course of treatment is two weeks, and the daily dosage is calculated based on the patient’s weight.
It is worthwhile to dwell in more detail on the method of treating children.
It is known that this medicine is available in several various forms appropriate for its purpose. These could be:
It's no secret that treating children has its own characteristics. You yourself know that it is difficult to explain to them that something healthy can be tasteless and disgusting.
Therefore, especially for such cases, a powder for the preparation of amoxiclav suspension for children is being produced.
In addition to the main components, fruit flavors and sweet ingredients are added to the powder to make the suspension have a pleasant taste and appeal to children.
The Forte variety contains a double dose of antibiotic. This suspension is prescribed for severe forms of infection:
What else do they write about Amoxiclav indications for use?
Speaking about the indications, I was asked why doctors rarely prescribe this medication for sore throat, therefore, I want to talk about this in more detail.
Let's start with the fact that the causative agents of sore throat can be bacteria, viruses or fungi.
Therefore, it is reasonable to prescribe amoxiclav for angina only if it is established that the causative agents are bacteria.
In any other case, treatment will be ineffective and will do more harm than good. For example, side effects are indicated in the indications for use.
Therefore, for the treatment of sore throat, antibiotics are prescribed only after preliminary microbiological tests to identify the pathogen and its sensitivity to drugs.
In conclusion, let me give you some advice. Perhaps analogues such as Augmentin or Flemoxin will be more effective for you.
By the way, if you know what other indications amoxiclav has for use, which I did not mention in the article, write comments.
Amoxiclav is combination drug, which contains semisynthetic penicillin and clavulanic acid. This drug is used for antibacterial therapy for many diseases of infectious etiology.
Table of contents: Dosage forms and composition of Amoxiclav Pharmacological action What diseases does Amoxiclav help with? Who is Amoxiclav contraindicated for? Recommended dosages Side effects Overdose Interaction of Amoxiclav with other drugs Amoxiclav during pregnancy and breastfeeding child Additional Rules for storage and dispensing from pharmacies Analogues of AmoxiclavAmoxiclav is produced in the form of regular and dispersible tablets, which contain the β-lactam antibiotic amoxicillin (250, 500 or 875 mg amoxicillin trihydrate) and the β-lactamase inhibitor clavulanic acid (125 mg potassium clavulanate).
The product is available in the form of a ready-made suspension and powder for its self-cooking . 5 ml of suspension contains 125, 250 or 400 mg of semi-synthetic penicillin, as well as 31.25, 62.5 or 57 mg of the potassium salt of clavulanic acid, respectively.
The liquid form is supplied in bottles of 35, 50, 70 and 140 ml, and the tablet form is supplied in blisters of 2, 5, 6, 8 and 20 pieces.
Amoxicillin is an antibiotic that is active against a wide range of pathogenic microflora. Many bacteria synthesize β-lactamase, which makes penicillin drugs ineffective. Therefore, the composition includes an inhibitor of this enzyme – clavulanic acid. Its potassium salt forms a stable inactive complex with the enzyme that destroys the antibiotic.
The drug is evenly distributed in the tissues and fluids of the body. After oral administration, the highest plasma concentration is recorded after 60 minutes. The degree of bioavailability of amoxicillin trihydrate is 90%, and potassium clavulanate is about 70%.
The process of biotransformation of drugs occurs in the liver, and the unchanged substance and its metabolites are excreted mainly in the urine.
This antibiotic is effective against infectious diseases caused by bacteria sensitive to β-lactam drugs.
Indications for the use of Amoxiclav are:
The drug is contraindicated in persons with individual hypersensitivity to active or auxiliary ingredients, as well as hypersensitivity to other antibacterial agents of the penicillin series. Caution must be exercised if you have a history of allergies to cephalosporins.
Please note
Do not take Amoxiclav if the use of amoxicillin in combination with clavulanic acid caused liver dysfunction or stagnation of bile.
Other contraindications include:
This antibacterial agent in tablet form is not prescribed to children and adolescents under 12 years of age.
Please note
Amoxicillin is intended for course treatment; The course duration ranges from 5 days to 2 weeks. Prolonged uncontrolled use and interruption of the course can contribute to the formation of antibiotic resistance in pathogenic microflora.
In terms of amoxicillin for mild or moderate course for an infectious disease, take 250 mg of the drug at 8-hour intervals (3 tablets per day).
For severe bacterial infections and diseases respiratory system 500 mg every 8 hours or 100 mg 2 times a day is indicated.
The maximum specified dose of amoxicillin trihydrate for patients over 12 years of age is 6 g, and potassium clavulanate is 600 mg.
Children under 12 years of age can be given a suspension. The dosage is determined at the rate of 45 mg/kg/day. (for amoxicillin) and 10 mg/kg/day. (for clavulanic acid). To make the liquid form easier to measure, the package includes pipettes or 5 ml measuring spoons.
Please note
Odonotogenic infections (periodontitis, periostitis) require taking 250/125 mg tablets 3 times a day for 5 days.
For suspensions of 125 and 250 mg of amoxicillin per 5 ml:
Babies in the first 3 months of life are given 30 mg/kg of the drug per day, dividing the dose into 2 doses. Children from 3 months. prescribed (depending on the severity of the infectious process) from 20 to 40 mg/kg per day, dividing the volume into 3 doses.
For suspensions of 400 mg/5 ml:
Amoxiclav with a high concentration of the antibacterial component is given at 25-45 mg/kg/day. for severe infections, dividing the dose into 2 doses.
Please note
To prepare a suspension, add boiled or distilled water to the bottle with powder, close the container with a lid, and shake vigorously until a homogeneous liquid is obtained.
Side effects
Most patients tolerate a course of antibiotic therapy with Amoxiclav without complications. In case of individual intolerance, allergic reactions may develop in the form of skin itching, rashes (urticaria) and angioedema. In severe situations, anaphylactic shock cannot be ruled out.
In rare cases, the following undesirable effects have been observed:
If age-related single and (or) daily dosages are significantly exceeded, various disorders are possible digestive function and disturbances of water-salt balance. Renal dysfunction is also possible.
Against the background of an overdose, psychomotor agitation, unmotivated feelings of anxiety, sleep disturbances and convulsions are sometimes noted.
The victim needs to have his stomach cleansed and symptomatic therapy. It is advisable to give the patient enterosorbents (according to age indications, these can be activated carbon, Smecta, Enterosorb, etc.). In severe situations, it may be necessary to hospitalize the victim in a specialized hospital department and carry out hardware cleanup blood - hemodialysis.
Plasma concentration of the antibiotic increases during administration Probenecida.
Amoxiclav increases overall toxicity Methotrexate due to slower excretion of the latter.
When combined with Allopurinol the risk of exanthema (skin rashes) increases.
The effectiveness of amoxicillin may be reduced when taken in parallel with macrolide antibiotics, tetracycline agents And sulfonamides.
A combined antibacterial drug can reduce the effectiveness birth control pills , because it interferes with their absorption.
Antagonism between Amoxiclav and Rifampicin (therapeutic effect mutually weakened).
Parallel use with indirect anticoagulants leads to an increase in prothrombin time, which increases the risk of bleeding of various locations.
Amoxicillin freely penetrates the blood-placental barrier, but this antibiotic does not have mutagenic, teratogenic or embryotoxic properties. Pregnant women can take it only as prescribed by their doctor. If it is necessary to carry out antibiotic therapy during lactation, the question may be raised about temporarily transferring the baby to artificial milk formula, although only a very small amount of antibiotic passes into breast milk.
To reduce the likelihood of dyspeptic disorders, it is advisable to drink Amoxiclav immediately after meals.
You do not need a doctor's prescription to purchase Amoxiclav.
The medicine should be stored in a place shielded from sunlight, at a temperature not exceeding +25°C.
The shelf life for suspension and tablets is 2 years from the date of issue (marked on the factory container).
Keep away from children!
Analogue drugs based on the active substance and mechanism of action include:
Plisov Vladimir, doctor, medical observer
Amoxiclav is used in gynecology, urology, and otolaryngology. This medicine is an antibiotic that contains amoxicillin and clavulanic acid.
Amoxiclav is a semi-synthetic penicillin that inhibits enzymes of pathogenic bacteria along the biosynthesis pathway. This leads to the death of the malicious infection.
Release form: tablets and suspension. In obstetrics, pills are prescribed for women. The suspension is recommended for children under 12 years of age.
Analogues of the drug Amoxiclav:
For what diseases should you take Amoxiclav?
Amoxiclav has shown particular effectiveness in gynecology in the treatment of ureaplasmosis. Instructions for use for Amoxiclav contain information that the drug is prescribed for chlamydia. But doctors recommend giving preference to Vilprafen in this pathology, because, as practice shows, chlamydia has become immune to Amoxiclav.
Contraindications:
The tablets should be taken with plenty of water. It is better to take the medicine after meals. Thus, the components of the medication will not affect the mucous membranes of the gastrointestinal tract.
The dosage of the drug is determined by the gynecologist for each individual patient. It all depends on the type of pathology, severity, age of the woman, general condition of the body, and the presence of other pathologies in the anamnesis.
The duration of therapy is from 5 days to 2 weeks. For treatment lung pathologies And medium degree severity, it is recommended to take 1 tablet (250) 3 times every 8 hours or 2 times throughout the day every 12 hours. For the treatment of severe pathologies - 1 tablet (500) 3 times a day or 1 tablet (875) mg every 12 hours.
Side effects:
At long-term use taking medications, dysbacteriosis may develop, and yeast-like fungi may develop on the skin and mucous membranes. Therefore, there is no need to self-medicate. The exact dosage prescribed by the gynecologist should be followed. No cases of overdose have been recorded.
Judging by the reviews of women who took Amoxiclav, side effects occur extremely rarely.
Use of Amoxiclav during pregnancy and lactation
Gynecological diseases very often develop during pregnancy. Amoxiclav is allowed to be taken during pregnancy and breastfeeding. This antibiotic is one of the few that does not have a harmful effect on the fetus. Amoxiclav acts only on the infection, without affecting intrauterine development fetus
The drug is prescribed after the woman undergoes a gynecological examination. Based on indications and examination results, a course of antibacterial therapy is prescribed.
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IN modern world More and more throat diseases require treatment with antibiotics. The most dangerous are bacterial infections, giving purulent complications.
The need to take antibiotics often arises in advanced (chronic) diseases, as well as in the event of complications after surgery. viral infection. If the course of the disease allows, it is better to conduct a sensitivity test to certain antibiotics in order to effective treatment. It is usually rarely possible to determine the type of bacteria before starting treatment. Antibiotics that have a fairly wide range of effects are usually used.
Such drugs include Amoxiclav, a combination drug that includes the following substances:
The components of the drug are quickly absorbed in the stomach and have a short elimination period. In this regard, treatment is carried out for a duration of 1 to 2 weeks, divided into several doses throughout the day.
When taking the medicine, you must drink enough fluid to prevent dehydration.
This medicine is used:
Amoxiclav is produced in the form of:
The type of drug and dose are determined by the doctor in accordance with the symptoms, nature and duration of the disease, as well as the age of the patient.
Main types medicinal product:
Amoxiclav tablets contain:
In case of illness with low-grade fever Both adults and children are prescribed 1 tablet of the drug (250 mg amoxicillin) three times a day, with an interval of eight hours.
In case of sore throat with more high temperature use the following scheme medicine: amoxicillin 500 mg with clavuanic acid – 125 g. In this case, it is enough to take 1 tablet 2 times a day with an interval of 12 hours.
In especially severe cases, the drug is prescribed 500 mg of amoxicillin 3 times a day, with an interval of eight hours.
The medicine in tablets can be used by chewing or dissolving in water.
This is important! Amoxiclav tablets can be given to children weighing over 40 kg.
To avoid side effects and harmful effects on the gastric microflora, it is better to take the drug immediately before meals.
The duration of treatment is determined by the doctor. There is one generally accepted rule - for a period of no more than 2 weeks.
In particularly severe cases of tonsillitis or other inflammatory diseases, amoxiclav must be administered intravenously. Injections are used to achieve a more stable patient’s condition with the ability to subsequently switch to tablets.
For intravenous administration, take sterile powder of the drug in vials, dilute it with water for injection, inject it into a vein very slowly or slowly inject it over 30 minutes. Such manipulations are carried out up to three times a day, monitoring the patient’s condition.
In the treatment of sore throat and other inflammatory diseases in children, the medicine is usually used in the form of a suspension. In pediatrics, the dosage calculation is made by the attending physician for each little patient individually. The calculations take into account the weight and age of the child, as well as the severity of the disease.
The daily amount of the drug for children over 3 months of age, based on amoxicillin, is thirty mg/kg.
So, if the patient weighs 8 kg, the daily dose of amoxicillin will be 240 mg. The drug in the form of a suspension is divided into two doses - 120 mg per dose and given to the patient at regular intervals with an interval of 12 hours.
If the patient weighs up to 40 kg (children from three months and older), the medicine is prescribed in a dosage of 20-25 mg per kg at moderate severity course of the disease up to 40-45 mg per kg in severe cases. Daily dose divided into 2-3 doses. Very rarely, when treating young patients, there is a need for intravenous antibiotics when the child cannot swallow independently in particularly severe cases of the disease.
Very often, it is difficult for parents of small children to correctly calculate the amount of suspension, since the doctor’s prescription most often contains only the amount of the active substance (amoxicillin, clavuanic acid), and not the amount of suspension.
When prescribing a medicine, you need to check with your doctor, down to the gram, in what proportion water is added to the powder, as well as how many milliliters of suspension to give to the child.
All active ingredients amoxiclav will be excreted by the kidneys at the same time, so in people suffering from renal failure the drug may be delayed. In this case, it is necessary to monitor the concentration of the drug in blood and urine and individually adjust the dosage and intervals of taking the medication. An antibiotic can give a false-positive urine test for glucose, which should also be taken into account for an objective interpretation of the test result.
Amoxiclav should not be taken by people who have previously had allergic reactions to antibiotics such as penicillins or cephalosporins.
It has been scientifically proven that patients suffering from infectious mononucleosis Using this drug may cause allergic reactions skin rash. Therefore, it is better for such people to use another drug.
Amoxiclav is prescribed with caution to pregnant women and people suffering from liver diseases.
Side effects when taking this drug occur extremely rarely, in most cases they are temporary and disappear when you stop taking the drug. If any side effects occur, you should immediately report them to your doctor.
