Staphylococcal bacteriophage - a real alternative to antibiotics or a drug with questionable effectiveness? Staphylococcal bacteriophage.

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Bacterial and viral infections in children are not uncommon. Their frequency increases in the cold season, with the beginning of visits kindergarten and schools. Many mothers worry when the disease has to be eliminated with the help of antibiotics, because they suppress not only pathogenic, but also beneficial microflora in the body. Bacteriophage for children – alternative way treatment, a drug that acts selectively only on infectious agents.

Bacteriophages have many advantages: they are approved for use in infants, are safe and effective. There are several types of such drugs, each of which is aimed at eliminating specific pathogens.

What are bacteriophages?

Most often, infections are caused by viruses and bacteria. Treatment in each case requires specific treatment, so it is necessary to distinguish what type of pathogen caused the disease. For viral infection characterized by short duration and severe symptoms, and for bacterial - a long course with less pronounced manifestations and more severe consequences. A combination of two types of diseases is often observed. In this case, first infection occurs with viruses, and then, due to weakened immunity, bacteria join.

The use of bacteriophages in children is indicated to eliminate infectious diseases with a bacterial component. These drugs are a certain type of virus. Due to their structure, they are able to penetrate bacterial cells and cause their decay.

The advantage of bacteriophages is that they act selectively. At the same time, beneficial microflora is preserved, and pathogenic microflora is destroyed. After a course of treatment, dysbiosis does not develop, as with the use of antibiotics. Another advantage of these drugs is that they do not cause bacterial resistance even after prolonged and repeated use.

Indications and contraindications for children

Bacteriophages are prescribed for infections of bacterial origin, when the type of pathogen is determined. For this purpose, at the diagnostic stage, a bacteriological and bacteriostatic analysis of the microflora is prescribed.

Bacteriophages for infants and older children are used in the treatment:

  • ear infections;
  • infections of the respiratory system (nose, nasopharynx, throat, larynx, trachea, lungs);
  • surgical infections, purulent wounds, burns, abscesses, furunculosis, etc.;
  • genitourinary infections;
  • eye infections, including those due to injury (, purulent lesion cornea);
  • infections gastrointestinal tract(gastroenterocolitis, cholecystitis, dysbacteriosis, etc.);
  • other infections caused by various types of bacteria.

It is acceptable to treat infants and even newborns with bacteriophages, since these drugs do not disturb the intestinal microflora and do not require additional intake of probiotics. There are no contraindications to their use. The only thing that can cause refusal to prescribe is the method of administration. Some newborns and infants experience pathological reactions after using an enema.

Varieties of bacteriophage

There are several types of bacteriophages, each of which affects specific pathogens:

  • Streptococcal bacteriophage is prescribed to infants and older children to treat infections caused by anaerobic bacteria Streptococcaceae. Once in the body, they multiply in the respiratory tract and digestive tract. Bacteriophages of this type are prescribed for otitis media, sinusitis, tonsillitis, laryngitis, pharyngitis, bronchitis, dysbacteriosis, cholecystitis and some other diseases.
  • Coliproteus bacteriophage affects coli This type of bacteria spreads in lower sections intestines. The drug is also effective against Proteus (Pr.mirabilis and Pr.vulgaris) - bacteria classified as opportunistic microflora intestines, that is, capable of becoming pathogenic under certain conditions. This type of bacteriophage is prescribed for enterocolitis and colpitis of coliproteus origin.
  • Klebsiella bacteriophage for infants and older children is prescribed for the treatment and prevention of infections caused by bacterial pathogens of the families Klebsiella rhinoscleromatis, Klebsiella ozaenae and Klebsiella pneumoniae. Indicated for onzema, scleroma, diseases of the gastrointestinal tract, surgical and urogenital infections, purulent-inflammatory processes in the respiratory tract and oral cavity.
  • Doctors prescribe staphylococcal bacteriophage to infants and older children for diseases of the ENT, digestive and respiratory tract, urogenital and surgical infections, purulent-inflammatory processes.
  • Pseudomonas aeruginosa bacteriophage is active against bacteria of the Pseudomonas aeruginosa family (Pseudomonas aeruginosa). Prescribed for the treatment of infections various localizations: in the ENT organs, respiratory tract, digestive tract, wounds, etc.
  • Salmonella bacteriophage is indicated for salmonellosis.
  • Dysentery bacteriophage is prescribed to children when they are infected with dysentery bacillus (Shigella dysenteriae). It enters the body with food, through the digestive organs. The indication for taking this drug is bacterial dysentery (shigellosis).
  • Typhoid bacteriophage is active against Salmonella typhoid fever, or Salmonella typhi. Prescribed for the treatment and prevention of intestinal infections caused by this pathogen.

There are preparations consisting of several sterile filtrates of phagolysates; they are called polyvalent bacteriophages and are widely used in pediatric practice. Polyvalent bacteriophage for children is most often Intestifage or Piobacteriphage. The first treats all infections of the gastrointestinal tract, the second treats purulent inflammatory infections.

Age dosage

Before giving a bacteriophage to a child, it is important to identify the causative agent of the infection. The dosage is determined by the age of the patient and the concentration of the drug. Intestinal and staphylococcal drugs are prescribed in childhood more often than others.

How to take staphylococcal and Intesti bacteriophage? Dosage of bacteriophages by age:

Age, years Staphylococcal bacteriophage(oral, ml) Staphylococcal bacteriophage (rectal, ml) Intesti bacteriophage (orally, ml) Intesti bacteriphage (rectal, ml)
0-0,5 5 10 5 10
0,5-1 10 20 15 20
1-3 15 30 20 30
3-8 20 40 30 40
8 or more 30 50 40 50

Staphylococcal bacteriophage may be administered to a child, including an infant, into the nose (2.5 ml up to six months of age).

During treatment you must adhere to the following rules:

  • Before giving staphylococcal bacteriophage to infants and older children to drink , you need to conduct a test by administering the drug rectally. Before the age of six months, spontaneous regurgitation and diarrhea may appear in response.
  • For infectious diseases of the gastrointestinal tract, intesti bacteriophage is prescribed. Before giving it to a child, you need to check the dosage with your doctor (the table shows the average values, without taking into account the severity of the disease).
  • Before giving intesti bacteriophage to an infant or older child, you must consult a doctor and undergo diagnostic examinations. When used internally, do a trial administration in the form of an enema.

Side effects

There are no clinical data on the side effects of bacteriophages. However, before treatment, you should consult a doctor and, in accordance with his recommendations, select the dose and method of administration of the drug.

Some infants exhibit pathological reactions in response to enemas. As a rule, these are frequent regurgitation, diarrhea and other digestive disorders.

Analogs

There are no drugs that would be structurally similar to bacteriophages. When replacing them, products with similar properties, but with different active substances, are prescribed.

The selection of substitutes should be made exclusively by a doctor. Many of them have contraindications and side effects. Staphylococcal bacteriophage, according to the instructions, allowed for infants, in certain cases can be replaced by Fosfomycin, Linemax, Monural, Zyvox, Forteraz and some other drugs.

Bacteriophages are actively used to treat infectious diseases in children. These products are aimed at eliminating a specific type of bacteria, so laboratory tests must be carried out before prescribing them. The advantage of bacteriophages is that they act selectively, preserving the beneficial microflora of the body, have no contraindications and side effects.

Useful video about bacteriophages

The composition of the drug includes: the active substance - a sterile filtrate of phagolysates of bacteria of the genus Staphylococcus and excipients - the preservatives 8-hydroxyquinoline sulfate or hydroxyquinoline sulfate monohydrate. Available in bottles of 20 or 100 milliliters. One pack contains 4 or 8 bottles of 20 ml or one bottle of 100 ml. The bacteriophage must be stored and transported at a temperature of 2 to 8 Co in a place protected from light rays.

Staphylococcal bacteriophage

  • Diseases of the oral cavity, throat, nose, nasopharynx, ear, respiratory tract (sinusitis, tonsillitis, pharyngitis, tonsillitis, bronchitis, laryngitis, pneumonia, pleurisy, tracheitis);
  • Urogenital infections (cystitis, colpitis, vaginosis, urethritis, pyelonephritis, salpingoophoritis, endometritis);
  • Enteroinfections (gastroenteritis, gastroenterocolitis, cholecystitis, intestinal dysbiosis);

Doses and rules of administration:

In children under 6 months: (at one time) orally (through the mouth) – 5 ml, rectally – 5-10 ml. If sepsis or enterocolitis occurs in children of this age (this also applies to premature babies), the bacteriophage is administered using high enemas - through a catheter or vent pipe per day 2-3 times at a dose of 5-10 ml. If there is no regurgitation or vomiting, you can administer the drug orally, mixing with breast milk. A combination of rectal and oral administration of the bacteriophage is possible. Usually the course of treatment lasts from 5 to 15 days. If the disease relapses, it is possible to carry out repeated courses of treatment.

In children from 6 to 12 months:

In children from 1 to 3 years:

In children from 3 to 8 years:

From 8 years and adults:

Staphylococcal bacteriophage.

Refers to pharmacological group drugs: MIBP-bacteriophage. Available in the form of a solution, used for oral administration, for rectal administration, local and external use in the form of applications, irrigations; is introduced into the nasal cavity, nasal sinuses, into the wound cavity, into drained cavities, into the vaginal cavity, uterus (use rules can be found here).

The composition of the drug includes: the active substance - a sterile filtrate of phagolysates of bacteria of the genus Staphylococcus and excipients - the preservatives 8-hydroxyquinoline sulfate or hydroxyquinoline sulfate monohydrate. Available in bottles of 20 or 100 milliliters. One pack contains 4 or 8 bottles of 20 ml or one bottle of 100 ml. The bacteriophage must be stored and transported at a temperature of 2 to 8 C o in a place protected from light rays.

The drug is suitable for use for two years from the date of release, subject to appropriate storage rules. But if, when purchasing a drug, the integrity of the bottles or labeling is damaged, the solution becomes cloudy or sediment is observed, or the expiration date has expired, then such a drug is not suitable for use.

Staphylococcal bacteriophage– it is a transparent liquid without sediment, yellow tint varying degrees of intensity. It has biological properties to cause specific lysis (dissolves the membrane) of Staphylococcus bacterial strains.

The bacteriophage does not have side effects, but may cause sensitivity to any components of the solution or intolerance. In such cases, the bacteriophage is contraindicated.

The bacteriophage can be used in combination with other pharmaceuticals, including antibiotics. No overdose of the drug was detected.

Staphylococcal bacteriophage is used for the treatment and prevention of various bacterial infections. These can be either purulent-inflammatory or enteral diseases, but there is only one condition for use - the presence of bacteria of the genus Staphylococcus, the strains of which are previously identified during bacterial culture.

Diseases with indications for the use of staphylococcal bacteriophage :

  • Diseases of the oral cavity, throat, nose, nasopharynx, ear, respiratory tract (sinusitis, tonsillitis, pharyngitis, tonsillitis, bronchitis, laryngitis, pneumonia, pleurisy, tracheitis);
  • Infections after surgical interventions (festering wounds, burns, phlegmon, abscess, carbuncle, furuncle, panaritium, osteomyelitis, mastitis, paraproctitis, bursitis, hydroadenitis);
  • Urogenital infections (cystitis, colpitis, vaginosis, urethritis, pyelonephritis, salpingoophoritis, endometritis);
  • Enteroinfections (gastroenteritis, gastroenterocolitis, cholecystitis, intestinal dysbiosis);
  • Septic diseases of a generalized nature;
  • Purulent – inflammatory diseases in newborns (pyoderma, omphalitis, sepsis, conjunctivitis, blepharitis, gastroenterocolitis and others);
  • Many other diseases are caused by the staphylococcus bacteria.
  • For particularly severe manifestations of staphylococcal infection, the drug is used in complex therapy along with other antibacterial agents.
  • To prevent wound infection, the drug is used in the treatment of newly infected and postoperative wounds.
  • To prevent nosocomial infections, the drug is used as part of epidemiological measures.

Doses and rules of administration:

During pregnancy and breastfeeding The bacteriophage is used in doses recommended by the doctor.

In children under 6 months. (at one time) orally (through the mouth) – 5 ml, rectally – 5-10 ml. If sepsis or enterocolitis occurs in children of this age (this also applies to premature babies), the bacteriophage is administered using high enemas - through a catheter or gas outlet tube 2-3 times per day in a dose of 5-10 ml. If there is no regurgitation or vomiting, the drug can be administered orally, mixed with breast milk. A combination of rectal and oral administration of the bacteriophage is possible. Usually the course of treatment lasts from 5 to 15 days. If the disease relapses, it is possible to carry out repeated courses of treatment.

For the prevention of sepsis and enterocolitis during intrauterine infection or in case of a threat of nosocomial infection in newborns the drug is used by enemas 2 times a day for 5-7 days.

For the treatment of omphalitis, pyoderma, and infected wounds in children of this age, the drug is used daily in the form of applications twice a day. In this case, a sterile gauze pad is moistened in a bacteriophage solution and applied to the umbilical wound or other affected areas of the skin.

In children from 6 to 12 months:(at one time) orally – 10 ml, rectally – 10-20 ml

In children from 1 to 3 years:(at one time) orally – 15 ml, rectally – 20-30 ml

In children from 3 to 8 years:(at one time) orally – 15-20 ml, rectally – 30-40 ml

From 8 years and adults:(at one time) orally – 20-30 ml, rectally – 40-50 ml

In the treatment of purulent-inflammatory diseases with limited lesions, it is carried out simultaneously local treatment and taking the drug orally 2-3 times on an empty stomach an hour before meals, starting from the first day of illness and for 7-20 days (according to indications).

If before using the bacteriophage solution the wound was treated with chemical antiseptics, then the wound before using the bacteriophage is first thoroughly washed with a sterile 0.9% sodium chloride solution.

Depending on the location of the foci of infection, staphylococcal bacteriophage is used:

By irrigation, rinsing, lotions, tamponing in volumes of up to 200 ml, depending on the size of the lesion. In case of an abscess, after removing the pus, a bacteriophage is injected into the wound using a puncture in an amount less than the volume of the removed purulent contents. For ostiomyelitis after surgical intervention a bacteriophage solution with a volume of 10-20 ml is poured into the wound.

When introducing a bacteriophage into the pleural, articular and other limited cavities use a volume of up to 100 ml, after which a capillary drainage is left through which the bacteriophage is introduced for the required number of days.

In case of cystitis, urethritis, pyelonephritis the drug is taken orally. When draining the cavity of the renal pelvis or bladder, the bacteriophage solution is administered through a nephrostomy or cystostomy up to two times a day inclusive in doses of 5 to 7 ml into the renal pelvis, from 20 to 50 ml into bladder.

For gynecological diseases of a purulent-inflammatory nature The bacteriophage is injected into the vagina (uterus) in doses of 5-10 ml once daily, in the case of colpitis - 10 ml, irrigated or tamponed twice a day. The tampon is placed for two hours.

Purulent-inflammatory diseases of the nose, throat, ear require the use of bacteriophage in doses of 2-10 ml 1 to 3 times a day. In this case, the bacteriophage solution is used in the form of instillation, irrigation, rinsing, washing, and turundas soaked in it are also introduced into the nasal passage (or ear canal) for an hour.

In cases of treatment of dysbiosis, enteral infections The bacteriophage is taken 1-3 times a day, an hour before the next meal. You can also combine oral administration of the bacteriophage with rectal administration (using an enema after a bowel movement) in a combination of two oral and one rectal administration per day.

Bacteriophages. Features of use in children

Infectious diseases in children can be caused by viruses or bacteria. Viral infections are treated with specific medications - antiviral drugs#8212; only in case of severe intoxication. Modern medicine treats diseases caused by pathogenic (disease-causing) microflora in two ways: by suppressing the entire microflora of the body (antibiotics) or selectively destroying pathogenic microflora (bacteriophages).

What are bacteriophages and how do they differ from antibiotics?

First of all, you need to understand that viral and bacterial infections are treated differently. If the course of a viral infection usually has a shorter duration and brighter manifestations, then a bacterial infection is not as pronounced, but its consequences are more severe.

Often, a bacterial infection is a complication of a viral one and occurs in parallel. In any case, to treat an infection that contains a bacterial component, suppression is necessary bacterial microflora. Bacteriophages are often prescribed for this purpose.

Bacteriophages are viral agents that invade bacterial cells and cause their decay and lysis. The essence of the interaction lies in the sensitivity of specific bacteria to certain bacteriophages.

The advantage of using bacteriophages in children is selectivity of influence. at which normal microflora remains unharmed while pathogenic bacteria die. The phenomena of dysbacteriosis are almost not observed. Another fundamental difference is the absence of resistance to bacteriophages. They will be effective every time and will not cause side effects that are difficult to treat such as dysbiosis.

Why is the drug used in children, and what is its principle of action?

Currently, bacteriophages are used for bacterial infections with a known type of pathogen. With a responsible approach to diagnosing an infection, the doctor prescribes bacterioscopic and bacteriological examination to determine the specific pathogen and prescribe the necessary drug.

Bacteriophage is effectively used to treat the following diseases in children:

  1. Diseases of the ears, upper respiratory tract, throat, lower respiratory tract and lungs.
  2. Surgical infections (treatment and prevention) - purulent wounds, burns, abscesses and phlegmons, furunculosis, etc.
  3. Infections of the genitourinary system.
  4. Post-traumatic eye infections, such as conjunctivitis and keratoconjunctivitis, purulent ulcers cornea.
  5. Diseases and infections of the gastrointestinal tract, for example, gastroenterocolitis, cholecystitis, dysbacteriosis after the use of antibiotics.
  6. Inflammatory diseases in newborns and infants.
  7. Other diseases caused by staphylococci, streptococci, Klebsiella and pathogenic bacilli.

The bacteriophage in children does not cause microflora disturbances and therefore does not require the use of probiotics, which can greatly reduce treatment costs.

The principle of action of bacteriophages is the selective effect of the bacteriophage on specific strains of bacteria. The phage attaches to a bacterial cell, penetrates it and begins to absorb its structures, thereby destroying it from the inside.

What types of bacteriophages are used in the treatment of childhood infectious diseases

Today the following groups of bacteriophages are used:

  • streptococcal,
  • coli-proteus,
  • klebsiella,
  • staphylococcal,
  • Pseudomonas aeruginosa,
  • salmonella,
  • dysenteric,
  • typhoid,
  • polyvalent bacteriophages.

Children are most often prescribed staphylococcal, streptococcal or polyvalent bacteriophages.

Staphylococcal and streptococcal bacteriophage are prescribed for the treatment of otitis, sinusitis, laryngitis, tracheitis, pharyngitis, tonsillitis, pleurisy, bronchitis or pneumonia.

There are also polyvalent bacteriophages for children such as Intestifage and Piobacteriophage. Intestifag is used to treat all bacterial infections of the gastrointestinal tract. Pyobacteriophage - as a prevention of purulent inflammatory infections.

How to give the drug to a child

The dosage of the drug depends on its concentration and age little patient. It's about about staphylococcal and intestinal bacteriophages, since they are prescribed to children in most cases.

Staphylococcal bacteriophage is usually prescribed to a child in the form of nasal drops, orally, or as enemas.

  1. Children under 6 months are prescribed 10 ml as an enema, 5 ml of bacteriophage orally (in the mouth) and 2.5 ml in the nose. Before taking staphylococcal bacteriophage, an infant must undergo an enema with the drug to check for possible side effects such as the development of spontaneous regurgitation.
  2. Children aged 6–12 months are prescribed 20 ml rectally and 10 ml orally.
  3. Children from one to three years of age are prescribed 30 ml of the drug rectally, 15 ml of the drug orally. It is important to remember that before taking staphylococcal bacteriophage, the child must administer the first dose of the drug in the form of an enema.
  4. Children 3–8 years old are given an enema with 40–50 ml of bacteriophage, and 20 ml are given by mouth.
  5. Children over 8 years of age are recommended to take 30 ml orally and 50 ml of the drug as an enema.

Before giving staphylococcal bacteriophage to children, in any case, it is necessary to consult a doctor and find out the causative agent.

For acute intestinal infections and sensitive bacterial infections, intesti-bacteriophage is used. How to give this drug to a child is described in detail below:

  1. Newborns and infants up to 6 months are given 5 ml of bacteriophage orally, and 10 ml at rectal administration.
  2. The dose of the drug at the age of 6–12 months is 10–15 ml orally and 20 ml when administered rectally as an enema.
  3. Average single dose the drug for children from one to three years old is 15–20 ml when taken orally and 20–30 ml as an enema.
  4. The dosage for a single administration for children 3–8 years old is 20–30 ml orally and 30–40 ml rectally.
  5. For children over 8 years of age, the dose of the drug is 30–40 ml of bacteriophage orally and 50–60 ml for rectal administration.

Contraindications

In pediatric practice, there are practically no contraindications for the use of drugs. The exception is the occurrence of pathological reactions after an enema during the use of bacteriophages for infants.

What to remember during treatment

  • The course of treatment with bacteriophages is 7–10 days.
  • Before giving the bacteriophage to an infant in the form of drops or an oral solution, it is necessary to administer the first dose of the drug as an enema and carefully monitor the reaction. If regurgitation, stool problems or other digestive disorders occur, you should contact your pediatrician for a second consultation.
  • The drug does not cause side effects, but before using it you need to get a doctor's advice.

How do bacteriophages work?

Staphylococcal bacteriophage is an ideal remedy that helps treat purulent diseases. The undoubted advantage of this drug is that it has absolutely no contraindications. The bacteriophage is naturally capable of quite effectively fighting absolutely any infectious diseases, however, you need to know how to take staphylococcal bacteriophage correctly and take into account the dosage.

1. This drug is good because it has no side effects, which is why it can be taken at any age. Moreover, it is completely indestructible immune system, but on the contrary, even strengthens it, thereby helping the body fight harmful microorganisms.

2. In order to be able to correctly take staphylococcal bacteriophage, it is necessary to initially determine the patient’s sensitivity to microorganisms and then calculate the resistance of various infections to the drug.

3. The bacteriophage is applied directly to the lesion itself. Treatment with this drug is carried out for two weeks, if necessary, the course of the required treatment is repeated until the patient completely recovers.

4. The most effective treatment with this drug will be diseases caused by a variety of microorganisms.

1. Knowing how to properly take staphylococcal bacteriophage, you can get rid of huge amount various bacteria that contribute to the development serious illnesses. If a person has purulent diseases of the nasopharynx, then the bacteriophage is used as special lotions and various rinses, which must be done approximately two to three times a day.

2. For various types intestinal diseases, the drug is taken orally three times a day approximately one hour immediately before meals. If there are boils, it is necessary to inject the drug directly into the source of the resulting inflammation, or into the resulting swelling.

3. When taking the drug, it is necessary to strictly follow the dosage and precautions so that side effects can be avoided.

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Bacteriophage refers to biological products that contain beneficial viruses that affect pathogenic microorganisms. The peculiarity of these drugs is that a certain medicine can fight only one type of virus. Staphylococcal bacteriophage, reviews of doctors about which characterize it as effective remedy for many diseases, refers specifically to such medications. This will be discussed further.

It should be noted right away that such a medicine cannot be taken without a doctor’s prescription. Self-medication can be bad for your health. The doctor prescribes such a medicine only after establishing accurate diagnosis and determining the type of harmful viruses in the body.

General information

The use of drugs with bacteriophages

Reviews will tell you how well these drugs affect the body. Staphylococcal bacteriophage copes well with purulent infections. It is used to treat mucous membranes, skin and visceral organs.

In addition to staphylococcal infections, certain types of bacteriophages are able to cope with Pseudomonas aeruginosa, streptococci, salmonella, enterococcal bacteria and a number of other harmful microorganisms.

When is staphylococcal bacteriophage used?

Reviews from doctors say that this medicine will help with the following diseases:

  • sinusitis;
  • angina;
  • otitis;
  • laryngitis and pharyngitis;
  • pneumonia, bronchitis and tracheitis;
  • pleurisy;
  • purulent wounds, abscess, panaritium, boil, complex burns with suppuration;
  • inflammatory processes urinary system, including cystitis, nephritis and pyelonephritis;
  • diseases of the digestive system caused by streptococcal infection, including gastritis, cholecystitis, gastroenterocolitis;
  • intestinal dysbiosis.

Release form

Staphylococcal bacteriophage is available in the form of a solution, packaged in 100 ml bottles in a cardboard box or 20 ml in a pack. Each box contains detailed instructions for use.

The drug is also available in tablets, in the form rectal suppositories and aerosol for comfortable use for various diseases.

Methods of using the medication and reviews

Staphylococcal bacteriophage, depending on the type of inflammatory focus, can be used as follows:

  • The solution is injected into the wound for an abscess after surgical intervention in the form of a puncture to remove purulent contents. The amount of the drug depends on the volume of removed pus and can reach 200 ml. The medicine is also effective for osteomyelitis, as evidenced by reviews. Staphylococcal bacteriophage is poured into the wound after treatment, 20 ml. The effect of the medicine is enhanced if, in addition to this, irrigation and lotions are given.
  • The drug is administered into limited cavities, such as the pleural and articular cavities, while a special drip drainage is left, through which the solution is added after a while.
  • Also, the medicine can be prescribed by a doctor for oral administration for diagnoses such as cystitis, urethritis, pyelonephritis. For patients with drained bladder or pelvis, the medicine is administered orally through a cystoma or nephrostomy up to 2 times a day (from 20 to 50 ml into the bladder and from 5 to 7 ml into the pelvis).
  • The drug will help cope with a number of gynecological diseases, and this is confirmed by numerous reviews. Staphylococcal bacteriophage is prescribed to patients with purulent-inflammatory foci. The solution is injected into the vagina or uterus, 5-10 ml every day. For a disease called colpitis, irrigation of 10 ml and tamponing 2 times a day for 2 hours will be effective.
  • This medicine will help cope with diseases of the ENT organs. Staphylococcal bacteriophage is very often prescribed for sore throat. Reviews from doctors say that rinsing with this solution helps rapid recovery patient. In addition, the medicine is instilled into the nose and used to moisten turundas in the ears.
  • How are staphylococcal bacteriophage reviews positioned? For dysbacteriosis and infectious lesions, the medication shows good results. It is prescribed 2-10 ml up to three times a day an hour before meals. In addition, rectal administration of the drug is also practiced to achieve maximum effect from therapy.
  • Staphylococcal bacteriophage will help with furunculosis. Reviews from patients indicate that spraying an aerosol and lotions in the form of applications speed up the process of tissue restoration and lead to a speedy recovery.

How is staphylococcal bacteriophage prescribed to adults? Reviews from doctors say that with an adequate approach to therapy using antibiotics and other drugs, positive dynamics are observed in such serious diseases as abscess, sepsis and other manifestations of advanced infection. However, early contact medical institution will allow you to timely diagnose the cause of a particular disease and provide assistance without waiting for complications and consequences.

Prescription for children

The drug is widely used in pediatrics. What do they say about such a medicine as staphylococcal bacteriophage? For infants, a disease such as omphalitis is very dangerous. It is manifested by suppuration at the umbilical wound, redness of the skin around it and swelling, as well as an inflammatory process in the subcutaneous fat layer. The cause of this disease is staphylococcal infection. Progression of the disease can lead to sepsis. Timely, systematic treatment of the wound with a composition such as staphylococcal bacteriophage will help quickly neutralize the effect of harmful microorganisms, which will lead to recovery.

Another common disease in infants is vesiculopustulosis. It is characterized by skin lesions, which are accompanied by the formation of bubbles with cloudy contents. The condition of the little patient depends on the number of rashes. The cause of the disease is also a staphylococcal infection, which can be defeated through lotions with a remedy such as staphylococcal bacteriophage.

Reviews about the treatment of children of different ages

In older children, staphylococcal skin lesions often manifest as furunculosis and folliculitis; in some cases, hidradenitis and carbuncles may be observed. How does the instruction advise to use the staphylococcal bacteriophage? For children (reviews from doctors confirm this) during treatment skin manifestations This type of treatment will be effective if you take an aerosol, as well as use lotions and applications on the affected areas of the skin.

For diseases of the gastrointestinal tract and respiratory system caused by staphylococci, which are characterized by obvious signs intoxication, oral and rectal administration of the drug may be prescribed.

What should you study before taking staphylococcal bacteriophage? Reviews. It is very important for children to carry out timely antibacterial therapy, which must be preceded by laboratory tests to identify the bacterium that caused the disease. This will help to quickly and without complications stabilize the condition of the little patient, which will lead to recovery.

Reviews about acne treatment

Quite often this drug used to treat skin imperfections, in particular, staphylococcal bacteriophage helps against acne. Reviews indicate that after treating areas of the skin affected by a pustular rash, the inflammation quickly goes away, leaving no scars or marks. This therapy can be used for rashes such as infants, and in adolescence. Naturally, the drug will be effective if the rash is caused by microorganisms sensitive to it.

Use in pregnant and lactating women

Contraindications for treatment in this period no, because the medicine has no side effects. Moreover, this biological product will become the most faithful assistant in treatment various diseases during periods when many other medications are contraindicated. The medicine should be used only on the recommendation of a doctor.

Contraindications and side effects

Due to the fact that the medicine is a biological product of natural origin, it has no side effects, nor can it cause an overdose. In addition, the medication can be part of a complex therapy and used together with antibiotics and other medications.

The only contraindication is intolerance to the components included in the drug.

Special requirements when using the medicine

The manufacturer of this medicine warns that under no circumstances should it be used if the integrity of the bottle is damaged. Also, it should not be used if it has expired or is cloudy.

The thing is that the drug contains live bacteria with a special environment in which harmful microorganisms can develop. They are what cause the solution to become cloudy. To prevent this phenomenon, you should adhere to the following rules when opening the bottle:

  • wash your hands thoroughly and treat them with an antiseptic;
  • wipe the bottle and cap with an alcohol solution;
  • do not allow the inner plug to come into contact with the table or other objects;
  • Do not leave the bottle of medicine open under any circumstances;
  • store the drug in the refrigerator.

To avoid premature deterioration of the solution, experts recommend removing the contents of the bottle by using a sterile syringe, which will need to carefully pierce the rubber stopper. Subject to these simple rules cloudiness will be avoided. This will allow you to make the most of the bottle until its contents expire.

The medicine can be stored for two years at a temperature of 2 to 8 degrees. If transportation is necessary, the temperature range from 9 to 25 degrees is allowed. However, the drug can remain in this state for no longer than one month. This medicine is sold in pharmacies without a prescription, so purchasing it is not difficult.

The active component of the drug Staphylococcal Bacteriophage is antistaphylococcal bacteriophage in liquid, suppository, ointment or tablet form.

Additional substance - quinosol.

Release form

  • 50 or 100 ml of such a solution in a bottle - one bottle in a cardboard box.
  • 20 ml of this solution in a bottle - four bottles in a cardboard box.
  • 25 ml of such a solution in aerosol packaging - one package in a cardboard box.
  • 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
  • 10 candles per package, one package in a cardboard box.
  • 10, 25 and 50 tablets per package, one package in a cardboard box.

Pharmacological action

Antibacterial action.

Pharmacodynamics and pharmacokinetics

What is a Bacteriophage?

This drug is relatively new on the drug market and many patients have a natural question: “Bacteriophage - what is it?”

Bacteriophages are viral particles that kill only certain species. pathogenic bacteria. On their basis, appropriate drugs are created. The discovery of the drugs belongs to the Canadian scientist Felix D'Herelle.

Structure of Bacteriophages

An ordinary bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double-stranded or single-stranded RNA or DNA with inactive transcriptase surrounded by a shell of protein or lipoprotein called capsid.

Reproduction of Bacteriophages

As with conventional viruses, the reproduction cycle of lytic bacteriophages can be divided into adsorption of the phage on the cell wall, introduction of DNA, reproduction of the phage, and evacuation of daughter populations from the cell.

Attachment of the phage to the bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, acidity of the environment, the presence of cations and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall splits enzymes lysozyme. At the same time, calcium ions are released, activating ATPase- this causes contraction of the sheath and insertion of the tail shaft into the cell. The viral DNA is then injected into the cytoplasm. Having penetrated the bacterium, the phage DNA takes control of the cell’s genetic apparatus, carrying out reproductive cycle phage.

First of all, the synthesis of enzymes necessary for the formation of copies of phage DNA occurs ( DNA polymerases, thymidylate synthetase, kinases). It takes 5-7 minutes from the moment of infection. RNA polymerase cells converts viral DNA into mitochondrial RNA, which is translated by ribosomes into “early” proteins. “Early” proteins are mainly viral RNA polymerase and proteins that limit bacterial gene expression. The viral RNA polymerase transcribes the so-called “late” proteins necessary for the assembly of new phage particles.

The reproduction of nucleic acids occurs due to the activity synthesized DNA polymerases virus. By the end of the cycle, the components of the phage are combined into a mature virion.

Evacuation of Bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes the DNA of the offspring. Specialized regions in the viral DNA induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail to form a daughter phage. After the offspring are released, the host cell is destroyed, releasing a new population.

An alternative to cell destruction may be an integrative form of interaction in which the phage DNA, instead of replicating, is integrated into the bacterial chromosome or becomes plasmid. As a result, the viral genome replicates along with the host DNA.

Types of Bacteriophages

The use of bacteriophages causes them clinical classification. Based on this thesis, we can highlight the following types bacteriophages:

  • bacteriophages for therapy intestinal infections : dysentery, polyvalent, salmonella ABCDE-group, typhoid, coliproteus, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
  • bacteriophages for therapy purulent-septic lesions: Klebsiella pneumoniae, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, Proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of infections of a purulent-septic nature).

The use of bacteriophage preparations in medicine is becoming increasingly widespread due to the increasing incidence of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to take this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus:

  • urogenital infections ( cystitis, urethritis, pyelonephritis, salpingoophoritis, endometritis, colpitis);
  • infections in surgery (burns, wound suppuration, abscesses, boils, phlegmon, carbuncles, felons, hidradenitis, paraproctitis, bursitis, mastitis, osteomyelitis);
  • diseases of the throat, ear, nose, respiratory organs ( inflammation of the middle ear, sinuses, pharyngitis, sore throat, pneumonia, laryngitis, bronchitis, tracheitis, pleurisy);
  • infections digestive tract (gastroenterocolitis), intestinal dysbiosis, cholecystitis;
  • prevention of postoperative septic complications;
  • prevention of hospital infections.

Contraindications

There are no contraindications to the use of this product.

Side effects

Adverse reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation.

Instructions for staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The frequency of injections and their size are determined using the definition clinical form illness, character infectious focus and standard recommendations. Average duration treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for using staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be used topically in the form of lotions, irrigation or tamponing in a volume of up to 200 ml, taking into account the size of the affected area. An ointment is also available for topical use.

Therapy purulent-inflammatory limited lesions It is advisable to carry out both locally and orally for 1-4 weeks.

At purulent-inflammatory lesions of the throat, ear or nose the drug is used for rinsing, instilling, washing and administering moistened turundas 2-10 ml up to three times a day.

At carbuncles And boils liquid bacteriophage injected directly into or around the lesion, 0.5-2 ml daily. In total, up to 5 injections are given per course of treatment.

Treatment chronic osteomyelitis carried out by infusing the drug into the wound immediately after surgical treatment.

At abscesses The bacteriophage is injected into the cavity of the lesion, emptied of pus. When opening an abscess, a tampon moistened with the drug is inserted into the wound.

Treatment of deep pyodermatitis carried out by making intradermal injections of the product into one place, 0.1-0.5 ml, or into several places in a total dose of up to 2 ml. Administration is carried out every 24 hours, a total of 10 injections.

For an introduction to abdominal, pleural, articular cavities use capillary drainage and inject up to 100 ml of bacteriophage every other day. There are only 3-4 such introductions.

At cystitis the drug is injected into the bladder using a catheter.

At purulent bursitis, pleurisy or arthritis the drug is administered into the cavity, previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 administrations.

Staphylococcal bacteriophage is also used orally in the form of tablets in the treatment of urogenital infections ( cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis), intestinal infections and other diseases caused by staphylococcus.

How to use Staphylococcal Bacteriophage for intestinal staphylococcal lesions And intestinal dysbiosis: the drug is used orally on an empty stomach three times a day 2 hours before meals; The drug is prescribed rectally in the form of suppositories or enemas once a day. Treatment lasts 7-10 days.

For newborn children, the drug is diluted with an equal amount of water in the first 2 doses. It can also be mixed with breast milk.

At sepsis or enterocolitis In newborns, the drug is used by performing high enemas up to three times a day. A combination of rectal and oral use is permitted.

At therapy of pyoderma, omphalitis, purulent wounds in newborns, the drug is used in the form of applications twice a day and in the form of tablets - 1 piece up to four times a day. The ointment is used locally with bandages of 5-20 grams up to two times a day.

For prevention enterocolitis And sepsis in newborns at risk of developing a hospital infection or intrauterine infection, the drug is used in the form of enemas twice a day for a week.

In aerosol form, staphylococcal bacteriophage is used to irrigate affected mucous membranes and skin during purulent-inflammatory lesions, burns, septic wounds And sore throat.

The most justified use this remedy in cases of infection antibiotic-resistant strains.

Overdose

Such cases have not been studied.

Interaction

If antiseptic solutions (not including furatsilin) the affected area should be washed with saline or 3% solution sodium bicarbonate.

Terms of sale

Dispensing of the drug is permitted without a prescription.

Storage conditions

Store at a temperature of 2-10 degrees in a dark place. Keep away from children.

Best before date

Special instructions

Treatment with the drug should be started as early as possible.

The drug must be shaken before use; a cloudy solution should not be used.

When opening the bottle, storing and sampling the product, the following rules should be observed:

  • hands must be washed thoroughly;
  • Before removing, the cap must be treated with an alcohol solution;
  • the cap should be removed without removing the stopper;
  • the drug should be removed from an opened bottle only by piercing the stopper with a sterile syringe;
  • If, during opening, the cork was accidentally uncorked along with the cap, then it should not be placed with the inner surface on the table, and the bottle should not be left open (after taking the product, it must be closed with the cork);
  • It is recommended to store the opened bottle in the refrigerator.

Subject to compliance with the specified rules and in the absence of turbidity, the product from the opened bottle can be used throughout the entire shelf life.

Analogs Level 4 ATX code matches:

Analogs of Staphylococcal Bacteriophage: 5-Nok, Dioxidin, Zyvox, Kirin, Kubitsin, Linezid, Linemax, Monural, Nitroxoline, Sextaphage, Piobacteriophage, Trobitsin, Forteraz, Fosmitsin.

The drug is approved for use in newborns and children of all ages.

With antibiotics

It is not prohibited to combine the drug with antibiotics.

During pregnancy and lactation

It is possible to use the product during the specified periods under the supervision of the attending physician.

The drug staphylococcal bacteriophage is a light yellow liquid, odorless and tasteless. Distinctive feature All bacteriophages are able to selectively destroy a specific type of pathogen, biting into a bacterial cell and feeding on its life-supporting structures, thereby contributing to the rapid death of the cell. Staphylococcal phage acts in this way on staphylococcal bacteria.

The bacteriophage cell includes a head containing single- or double-stranded RNA with deactivated transcriptase in an amino acid shell, and a tail that is approximately 3 times longer than the head.

When attaching to a staphylococcal cell, the phage releases lysozyme, which destroys the cell wall, releasing calcium and activating ATP. The phage injects its RNA into the cell and from this moment the bacteriophage begins to control the genetic apparatus of the cell. Thanks to the synthesis of multiple enzymes, it becomes possible formation many new copies of the phage capturing new bacterial cells.

Can it be given to children?

The drug is approved for use in children starting from six months of age. When using and selecting the dosage, you must strictly follow the instructions in these instructions.

If a child experiences an adverse reaction to a syringe test, it is not recommended to give the drug. The bacteriophage does not provoke changes in the intestinal microflora, so when consuming it there is no need to resort to antibiotics.

Indications for use

  • Infectious inflammatory diseases of the ENT organs.
  • Infections of the genitourinary system.
  • Intestinal infections and dysbiosis.
  • Other purulent-inflammatory processes, the diagnosis of which revealed the presence of staphylococci.

Forms of release of the drug and conditions of release from pharmacies

The drug is produced in the form of a solution for oral and external use in opaque glass bottles with a capacity of 20, 50 or 100 ml. Bottles with a capacity of 20 ml are packaged in cardboard boxes of 4 bottles, with a capacity of 50 and 100 ml - produced in individual packaging. All packages have instructions for use inside.

The solution is also available as aerosol, in a 25 ml bottle with instructions for use.

Pills are produced in blisters of 10, 25 and 50 pieces, packed in a cardboard box. One box contains one blister and instructions for use.

Candles Available in packs of 10 pieces in a cardboard box.

Ointment Available in tubes of 10 and 20 grams, in cardboard packaging with instructions for use.

All forms of the drug are available in pharmacies without a prescription.

Instructions for use

The course of treatment with bacteriophage is 6-9 days and involves a combination of rectal and oral administration of the drug.

At rectal use Children under 6 months should be given 10 ml of phage, from 6 months to a year - 20 ml, from one to three years - 30 ml, and older ones - 50 ml.

Dosage for oral use: up to 6 months - 5 ml, from 6 months to a year - 10 ml, from one to three years - 35 ml, from 3 to 8 years - 20 ml, for older ones - 30 ml. Children under one year of age are given half the indicated dosage of the drug in the first two doses, mixed with milk or water.

An aerosol with phage is used for irrigation of the oropharyngeal cavity in case of sore throat, pharyngitis, for irrigation of purulent and inflamed areas skin and mucous membranes.

For festering wounds, a combination of topical application (bandage with ointment, change twice a day) and tablets (up to 4 pieces per day) is recommended. Before your appointment be sure to consult your doctor!

Compound

1 ml of solution contains up to 1 ml active substancephagolysates of staphylococcal bacteria.

Excipients: preservative 8-hydroxyquinoline sulfate - about 0.1 ml.

Contraindications

In pediatric practice, there are practically no contraindications for the use of bacteriophage preparations. The exception is the occurrence of pathological reactions after a test enema during the use of bacteriophages for infants.

Side effects

When administered subcutaneously into the body, short-term swelling and redness of the surface may be observed.

Otherwise, undesirable effects when taking the drug are possible only in the presence of increased individual sensitivity to active substance. Before starting to use the product for a child, it is advisable to test for a pathological reaction by administering a microenema with a bacteriophage solution. Whenever adverse reactions Oral use of the drug is not allowed.

Analogs

  • Kubitsin
  • Trobitsin
  • Nitroxoline
  • Dioxidine

Modern medicine treats diseases caused by pathogenic (disease-causing) microflora in two ways: by suppressing the entire microflora of the body (antibiotics) or selectively destroying pathogenic microflora (bacteriophages).

What are bacteriophages and how do they differ from antibiotics?

First of all, you need to understand that viral and bacterial infections are treated differently. If the course of a viral infection usually has a shorter duration and brighter manifestations, then a bacterial infection is not as pronounced, but its consequences are more severe.

Often, a bacterial infection is a complication of a viral one and occurs in parallel. In any case, to treat an infection that contains a bacterial component, it is necessary to suppress the bacterial microflora. Bacteriophages are often prescribed for this purpose.

Bacteriophages are viral agents that invade bacterial cells and cause their decay and lysis. The essence of the interaction lies in the sensitivity of specific bacteria to certain bacteriophages.

The advantage of using bacteriophages in children is the selectivity of the effect, in which the normal microflora remains unharmed, while pathogenic bacteria die. The phenomena of dysbacteriosis are almost not observed. Another fundamental difference is the absence of resistance to bacteriophages. They will be effective every time and will not cause side effects that are difficult to treat such as dysbiosis.

Why is the drug used in children, and what is its principle of action?

Currently, bacteriophages are used for bacterial infections with a known type of pathogen. With a responsible approach to diagnosing an infection, the doctor prescribes a bacterioscopic and bacteriological examination to determine the specific pathogen and prescribe the necessary drug.

Bacteriophage is effectively used to treat the following diseases in children:

  1. Diseases of the ears, upper respiratory tract, throat, lower respiratory tract and lungs.
  2. Surgical infections (treatment and prevention) - purulent wounds, burns, abscesses and phlegmons, furunculosis, etc.
  3. Infections of the genitourinary system.
  4. Post-traumatic eye infections, such as conjunctivitis and keratoconjunctivitis, purulent corneal ulcers.
  5. Diseases and infections of the gastrointestinal tract, for example, gastroenterocolitis, cholecystitis, dysbacteriosis after the use of antibiotics.
  6. Inflammatory diseases in newborns and infants.
  7. Other diseases caused by staphylococci, streptococci, Klebsiella and pathogenic bacilli.

The bacteriophage in children does not cause microflora disturbances and therefore does not require the use of probiotics, which can greatly reduce treatment costs.

The principle of action of bacteriophages is the selective effect of the bacteriophage on specific strains of bacteria. The phage attaches to a bacterial cell, penetrates it and begins to absorb its structures, thereby destroying it from the inside.

What types of bacteriophages are used in the treatment of childhood infectious diseases

Today the following groups of bacteriophages are used:

  • streptococcal,
  • coli-proteus,
  • klebsiella,
  • staphylococcal,
  • Pseudomonas aeruginosa,
  • salmonella,
  • dysenteric,
  • typhoid,
  • polyvalent bacteriophages.

Children are most often prescribed staphylococcal, streptococcal or polyvalent bacteriophages.

Staphylococcal and streptococcal bacteriophage are prescribed for the treatment of otitis, sinusitis, laryngitis, tracheitis, pharyngitis, tonsillitis, pleurisy, bronchitis or pneumonia.

There are also polyvalent bacteriophages for children such as Intestifage and Piobacteriophage. Intestifag is used to treat all bacterial infections of the gastrointestinal tract. Pyobacteriophage - as a prevention of purulent inflammatory infections.

How to give the drug to a child

The dosage of the drug depends on its concentration and the age of the small patient. We will talk about staphylococcal and intestinal bacteriophages, since they are prescribed to children in most cases.

Staphylococcal bacteriophage is usually prescribed to a child in the form of nasal drops, orally, or as enemas.

  1. Children under 6 months are prescribed 10 ml as an enema, 5 ml of bacteriophage orally (in the mouth) and 2.5 ml in the nose. Before taking staphylococcal bacteriophage, an infant must undergo an enema with the drug to check for possible side effects such as the development of spontaneous regurgitation.
  2. Children aged 6–12 months are prescribed 20 ml rectally and 10 ml orally.
  3. Children from one to three years of age are prescribed 30 ml of the drug rectally, 15 ml of the drug orally. It is important to remember that before taking staphylococcal bacteriophage, the child must administer the first dose of the drug in the form of an enema.
  4. Children 3–8 years old are given an enema with 40–50 ml of bacteriophage, and 20 ml are given by mouth.
  5. Children over 8 years of age are recommended to take 30 ml orally and 50 ml of the drug as an enema.

Before giving staphylococcal bacteriophage to children, in any case, it is necessary to consult a doctor and find out the causative agent.

For acute intestinal infections and sensitive bacterial infections, intesti-bacteriophage is used. How to give this drug to a child is described in detail below:

  1. Newborns and infants up to 6 months are given 5 ml of bacteriophage orally, and 10 ml by rectal administration.
  2. The dose of the drug at the age of 6–12 months is 10–15 ml orally and 20 ml when administered rectally as an enema.
  3. The average single dose of the drug for children from one to three years of age is 15–20 ml orally and 20–30 ml as an enema.
  4. The dosage for a single administration for children 3–8 years old is 20–30 ml orally and 30–40 ml rectally.
  5. For children over 8 years of age, the dose of the drug is 30–40 ml of bacteriophage orally and 50–60 ml for rectal administration.

Contraindications

In pediatric practice, there are practically no contraindications for the use of drugs. The exception is the occurrence of pathological reactions after an enema during the use of bacteriophages for infants.

What to remember during treatment

  • The course of treatment with bacteriophages is 7–10 days.
  • Before giving the bacteriophage to an infant in the form of drops or an oral solution, it is necessary to administer the first dose of the drug as an enema and carefully monitor the reaction. If regurgitation, stool problems or other digestive disorders occur, you should contact your pediatrician for a second consultation.
  • The drug does not cause side effects, but before using it you need to get a doctor's advice.

How to give staphylococcal bacteriophage to a newborn

The pediatrician told us to give 5 ml 30 minutes before meals.

Is it really necessary to strictly wait 30 minutes before meals (this is very inconvenient)?

I gave it to a child for the first time, with a syringe in his mouth, and he probably spat out half of it.

Maybe you can add it to the mixture?

And in the evening they said 10 ml through an enema.

And that comes out to 5 ml 3 times through the mouth and 10 ml in an enema. Isn’t that a lot?

make sure it’s not cold, it needs to be stored in the refrigerator! I was warming the syringe in my hands!

I gave 5 ml three times a day only by mouth!

We weren't very upset, so we did without enemas. In general, my pediatrician said that enemas are not needed if you give them by mouth on a strict regimen! And she also said that if you don’t have an enema, then do the course for 10 or even 14 days!

What bacteriophage do you have?

The medicine should be given when the child is lying on his back and holding his cheeks until he swallows!

We gave 2 times a day 5 ml + enema 5 ml of medicine diluted with 5 ml of water!

But it all depends on the specific phage!

Be careful. The result depends on compliance with the treatment regimen. You are not giving it for show, but to cure the child.

We consulted with the pediatrician, she allowed us to give everything through an enema

and in terms of dosage - it always depends on the specific phage and the age of the child

I see they assigned us the most :(

But we have no clinical manifestations at all, except for greenery in the stool. And that’s not always the case.

Thanks everyone for the answers.

I just read in the annotation that it can be given in breast milk. Well, since it can be given in breast milk, then I thought that it could be given in formula.

For example, we added Linex to the mix.

The whole question here is the sensitivity of one or another to drugs.

only for this purpose the wide edge of the gas outlet needs to be cut off

Our staff was sensitive only to pyobacteriophage, for example. and the rivet. - not sensitive to anything at all:001:

Our klepsa was sensitive only to antibiotics, but the sextaphage killed it too: 015:

The child kept spitting out the medicine. Profuse regurgitation began.

At first they gave it 30 minutes before meals, but it was terribly inconvenient for us. Because The baby usually slept before feeding. I had to wake him up.

Then they adapted and gave it 1-1.5 hours after feeding.

But we don't have an enema. She poured it into her mouth with a syringe.

Exactly, the child really liked it :)

We also gave 3 times a day, 5 ml per. how it turned out.

And it should be given half an hour before meals so that the child does not regurgitate the medicine.

How to give Staphylococcal Bacteriophage?

didn't the doctor tell you?

What is this? what is this from?

or they just decided to give it.

Check with your doctor!

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Bacteriophage Staphylococcal

Compound

The active component of the drug Staphylococcal Bacteriophage is an anti-staphylococcal bacteriophage in liquid form, in the form of suppositories, ointments or tablets.

Release form

  • 50 or 100 ml of such a solution in a bottle - one bottle in a cardboard box.
  • 20 ml of this solution in a bottle - four bottles in a cardboard box.
  • 25 ml of such a solution in aerosol packaging - one package in a cardboard box.
  • 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
  • 10 candles per package, one package in a cardboard box.
  • 10, 25 and 50 tablets per package, one package in a cardboard box.

Pharmacological action

Pharmacodynamics and pharmacokinetics

This drug is relatively new on the drug market and many patients have a natural question: “Bacteriophage - what is it?”

Bacteriophages are viral particles that kill only certain types of pathogenic bacteria. On their basis, appropriate drugs are created. The discovery of the drugs belongs to the Canadian scientist Felix D'Herelle.

An ordinary bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double- or single-stranded RNA or DNA with an inactive transcriptase, surrounded by a shell of protein or lipoprotein called the capsid.

As with conventional viruses, the reproduction cycle of lytic bacteriophages can be divided into adsorption of the phage on the cell wall, introduction of DNA, reproduction of the phage, and evacuation of daughter populations from the cell.

Attachment of the phage to the bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, acidity of the environment, the presence of cations and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall is broken down by lysozyme enzymes. At the same time, calcium ions are released, activating ATPase - this causes contraction of the sheath and insertion of the tail shaft into the cell. The viral DNA is then injected into the cytoplasm. Having penetrated the bacterium, the phage DNA takes control of the cell’s genetic apparatus, carrying out the phage’s reproductive cycle.

First of all, the synthesis of enzymes necessary for the formation of copies of phage DNA (DNA polymerase, thymidylate synthetase, kinase) occurs. It takes 5-7 minutes from the moment of infection. The cell's RNA polymerase converts viral DNA into mitochondrial RNA, which is translated by ribosomes into early proteins. “Early” proteins are mainly viral RNA polymerase and proteins that limit the expression of bacterial genes. The viral RNA polymerase transcribes the so-called “late” proteins necessary for the assembly of new phage particles.

The reproduction of nucleic acids occurs due to the activity of synthesized DNA polymerases of the virus. By the end of the cycle, the components of the phage are combined into a mature virion.

Evacuation of Bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes the DNA of the offspring. Specialized regions in the viral DNA induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail to form a daughter phage. After the offspring are released, the host cell is destroyed, releasing a new population.

An alternative to cell destruction may be an integrative form of interaction in which the phage DNA, instead of replication, is integrated into the bacterial chromosome or becomes a plasmid. As a result, the viral genome replicates along with the host DNA.

The use of bacteriophages determines their clinical classification. Based on this thesis, the following types of bacteriophages can be distinguished:

  • bacteriophages for the treatment of intestinal infections: dysentery, polyvalent, salmonella ABCDE-group, typhoid, coliproteus, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
  • bacteriophages for the treatment of purulent-septic lesions: Klebsiella pneumoniae, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, Proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of infections of a purulent-septic nature).

The use of bacteriophage preparations in medicine is becoming increasingly widespread due to the increasing incidence of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to take this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus:

  • urogenital infections (cystitis, urethritis, pyelonephritis, salpingoophoritis, endometritis, colpitis);
  • infections in surgery (burns, wound suppuration, abscesses, boils, phlegmon, carbuncles, felons, hidradenitis, paraproctitis, bursitis, mastitis, osteomyelitis);
  • diseases of the throat, ear, nose, respiratory organs (inflammation of the middle ear, sinuses, pharyngitis, sore throat, pneumonia, laryngitis, bronchitis, tracheitis, pleurisy);
  • infections of the digestive tract (gastroenterocolitis), intestinal dysbiosis, cholecystitis;
  • prevention of postoperative septic complications;
  • prevention of hospital infections.

Contraindications

There are no contraindications to the use of this product.

Side effects

Adverse reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation are possible.

Instructions for staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The frequency of injections and their size are determined by determining the clinical form of the disease, the nature of the infectious focus and standard recommendations. The average duration of treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for using staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be used topically in the form of lotions, irrigation or tamponing in a volume of up to 200 ml, taking into account the size of the affected area. An ointment is also available for topical use.

It is advisable to carry out therapy of purulent-inflammatory limited lesions both locally and orally for 1-4 weeks.

For purulent-inflammatory lesions of the throat, ear or nose, the drug is used for rinsing, instilling, washing and administering moistened turundas 2-10 ml up to three times a day.

For carbuncles and boils, liquid bacteriophage is injected directly into or around the lesion, 0.5-2 ml daily. In total, up to 5 injections are given per course of treatment.

Treatment of chronic osteomyelitis is carried out by infusion of the drug into the wound immediately after surgical treatment.

In case of abscesses, the bacteriophage is injected into the cavity of the lesion, emptied of pus. When opening an abscess, a tampon moistened with the drug is inserted into the wound.

Treatment of deep pyodermatitis is carried out by intradermal injections of the drug into one place of 0.1-0.5 ml or into several places in a total dose of up to 2 ml. Administration is carried out every 24 hours, a total of 10 injections.

For administration into the abdominal, pleural, and articular cavities, capillary drainage is used, and up to 100 ml of bacteriophage is injected every other day. There are only 3-4 such introductions.

For cystitis, the drug is injected into the bladder using a catheter.

For purulent bursitis, pleurisy or arthritis, the drug is administered into a cavity previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 administrations.

Also, Staphylococcal bacteriophage is used orally in the form of tablets in the treatment of urogenital infections (cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis), intestinal infections and other diseases caused by staphylococcus.

How to use Staphylococcal Bacteriophage for intestinal staphylococcal lesions and intestinal dysbiosis: the drug is used orally on an empty stomach three times a day, 2 hours before meals; The drug is prescribed rectally in the form of suppositories or enemas once a day. Treatment lasts 7-10 days.

For newborn children, the drug is diluted with an equal amount of water in the first 2 doses. It can also be mixed with breast milk.

For sepsis or enterocolitis in newborns, the drug is used by performing high enemas up to three times a day. A combination of rectal and oral use is permitted.

When treating pyoderma, omphalitis, purulent wounds in newborns, the drug is used in the form of applications twice a day and in the form of tablets - 1 piece up to four times a day. The ointment is used locally with bandages of 5-20 grams up to two times a day.

For the prevention of enterocolitis and sepsis in newborns, when there is a risk of developing a hospital infection or intrauterine infection, the drug is used in the form of enemas twice a day for a week.

In aerosol form, Staphylococcal Bacteriophage is used to irrigate affected mucous membranes and skin for purulent-inflammatory lesions, burns, septic wounds and sore throat.

The most justified use of this remedy is in cases of infection with antibiotic-resistant strains.

Overdose

Such cases have not been studied.

Interaction

If antiseptic solutions (not including furatsilin) ​​were used before local application of the product, the affected area should be washed with saline solution or 3% sodium bicarbonate solution.

Terms of sale

Dispensing of the drug is permitted without a prescription.

Storage conditions

Store at a temperature of 2-10 degrees in a dark place. Keep away from children.

Best before date

Special instructions

Treatment with the drug should be started as early as possible.

The drug must be shaken before use; a cloudy solution should not be used.

When opening the bottle, storing and sampling the product, the following rules should be observed:

  • hands must be washed thoroughly;
  • Before removing, the cap must be treated with an alcohol solution;
  • the cap should be removed without removing the stopper;
  • the drug should be removed from an opened bottle only by piercing the stopper with a sterile syringe;
  • If, during opening, the cork was accidentally uncorked along with the cap, then it should not be placed with the inner surface on the table, and the bottle should not be left open (after taking the product, it must be closed with the cork);
  • It is recommended to store the opened bottle in the refrigerator.

Subject to compliance with the specified rules and in the absence of turbidity, the product from the opened bottle can be used throughout the entire shelf life.

Analogs

Analogs of Staphylococcal Bacteriophage: 5-Nok, Dioxidin, Zyvox, Kirin, Kubitsin, Linezid, Linemax, Monural, Nitroxoline, Sextaphage, Piobacteriophage, Trobitsin, Forteraz, Fosmitsin.

For children

The drug is approved for use in newborns and children of all ages.

With antibiotics

It is not prohibited to combine the drug with antibiotics.

During pregnancy and lactation

It is possible to use the product during the specified periods under the supervision of the attending physician.

Reviews of Staphylococcal Bacteriophage

Despite many cases of cure, the therapeutic effect of taking the drug is not guaranteed in all cases. This is evidenced by reviews of Staphylococcal Bacteriophage. This feature is more often detected when the drug is used for newborns and young children.

The effectiveness of the drug may vary depending on the sensitivity of the particular strain to the phage and other factors that should be determined before starting treatment.

In some situations, parents prematurely stop the course of treatment for their infant, frightened by the supposedly worsening symptoms of the disease, and then report that the drug did not work on the child. In any case, before deciding to undergo therapy with this medicine, and during treatment, you should be observed by your doctor and clarify all unclear questions with him.

Staphylococcal Bacteriophage price, where to buy

In Ukraine, the price of the drug Staphylococcal Bacteriophage liquid 100 ml produced by the Biopharma company (Kiev) averages 318 hryvnia.

In Russia, the price of staphylococcal and polyvalent Pyobacteriophage liquid bacteriophage is standard packaging 20 ml No. 4 is almost the same and amounts to rubles.

Buying a staphylococcal bacteriophage in Moscow (manufactured by NPO Microgen, Nizhny Novgorod) will cost rubles per 100 ml bottle.

Such drugs are almost never found in tablet or suppository forms in pharmacies.

  • Online pharmacies in Russia Russia

Pharmacy 36.6

Bacteriophage staphylococcal liquid 100ml MICROGEN

Bacteriophage staphylococcal liquid 20ml N4 MICROGEN

ZdravZone

Staphylococcal bacteriophage 100ml ImBio-Nizhny Novgorod State Enterprise

Bacteriophage staphylococcal liquid 20ml No. 4 bottles Microgen NPO Federal State Unitary Enterprise

Pharmacy IFC

Bacteriophage staphylococcal liquid Biomed (Perm), Russia

Bacteriophage staphylococcal liquid Microgen NPO FSUE (ImBio N. Novgorod), Russia

Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before use medicinal product Bacteriophage Staphylococcal, be sure to consult with your doctor.

Bacteriophage Klebsiella Polyvalent Purified

Lysozyme

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All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The information published on the site is for informational purposes only. Described methods of diagnosis, treatment, recipes traditional medicine etc. It is not recommended to use it on your own. Be sure to consult a specialist so as not to harm your health!

How to give staphylococcal bacteriophage to a baby

Staphylococcus aureus. Child from 3 to 7

Girls, tell me, if anyone has experience in treating Staphylococcus aureus in a child... My daughter was diagnosed with it, which is the cause of our constant illnesses... As I understand it, we need to be tested for the sensitivity of this staphylococcus to some antibiotic/antiseptic, this is so . As soon as sensitivity is detected, undergo a course of treatment with this drug. Anyone who has experience, please share. Thank you in advance.

Staphylococcus in breast milk.. Children's medicine

The child is 2 months old, has a problem with abdominal pain/digestion, tests showed Staphylococcus aureus and Proteus bacteria in the child’s stool and Staphylococcus epidermidis in the mother’s breast milk. Doctors advise expressing milk for a month, boiling it + a course of antibiotics for the mother (which can lead to loss of breastfeeding) and a course of bacteriophage + bifidobacteria for a child. Anyone who has encountered a similar situation, please respond, maybe someone solved this problem differently, without antibiotics. Who can.

Staphylococcus. Child from birth to one year

found in small quantities. And lacto- and bifidobacteria were also reduced. They prescribed staphylococcal bacteriophage and primadophilus. And a lot of abomin. For me, the word “staphylococcus” in itself is scarier than a horror movie. Cheats his brains out.

Everything will be fine, Natasha :)

Where does staphylococcus in poop come from? Child from birth.

Oh, we’re just treating one thing or another. We tested stool for dysbacteriosis and scatology. Found staphylococcus. Well, where is it from? The pediatrician didn't say anything clearly. Bacteriophage Staf was prescribed. inside and an enema with him. I wonder if you hadn’t taken the test, what would have happened? Where does all this come from anyway?

staphylococcus Pediatric medicine

And we were discovered Staphylococcus aureus. We are almost 3 months old. Anyone who has had this, tell me what they treated it with

Staphylococcus aureus in infants. Child from birth to one year

Treat staphylococcus or introduce complementary foods? Child from birth.

Puzzled. I read a lot that all treatment is useless. I read a lot that with the introduction of complementary foods everything goes away on its own. The drugs are not cheap. I don’t want to just stuff the baby with them and spend money in the morning. Maybe try introducing complementary foods first? Or should I still try to treat it before complementary feeding? PS we don’t have very many symptoms good chair and diathesis with improvements on hydrolyzate.

I would treat it with bacteriophages. According to my observations, it helps. IMHO.

Of course, phages are expensive and taste nasty. But they still treat.

Staphylococcal bacteriophage?? How to accept

Tell me, maybe someone knows how to take staphylococcus bacteriophage for Staphylococcus aureus to a 4-year-old child. They did a throat swab and found this infection. The local pediatrician said - take the bacteriophage for 15 days according to the instructions. But the instructions turned out to be ambiguous - from 1 or more doses per day, a single portion. The pediatrician went on vacation, the child went to his grandmother, who bought medicine and is waiting for instructions from me.

bacteriophages. Child from birth to one year

Girls, who drank these bacteriophages?? We were prescribed Intesti-bacteriophage 5 ml - 3 times a day + Normoflorin L. I read the following information on the Internet: When taking bacteriophages, bacterial lysis products are formed and they must be removed using enterosorbents. Otherwise, intoxication is possible. But they didn’t appoint me for smecta or anything else :(

We took a course of Linex and everything went away with complementary foods. True, we started complementary feeding at 3.5 months.

Who was treated with bacteriophages? Child from birth to one year

We found Staphylococcus aureus. They prescribed us an intesti-bacteriophage. Not only is this indescribable disgusting, but it is also written in the instructions - give 5 ml in the mouth and 10 ml as an enema. How to give a child 10 ml with an enema? What device can I do this with? In general, I can’t force a child 4 times a day with an enema. The treatment will suffer greatly - if we only drink this?

Consultation on breastfeeding and child care

Consultation on breastfeeding and child care Breastfeeding is the key to the successful development and health of the baby. Our consultants will help you: learn breastfeeding techniques; learn how to care for a newborn and a child in the first three years of life; prolong lactation and switch from bottle to breastfeeding; they will tell you how to combine breastfeeding with going to work; wean; arrange feeding for the adopted child. They will help and tell you how.

Another episode about the house). Blog of user Styusha on 7ya.ru

I don’t even know where to post this now.. so I’ll leave it only on the blog.. who is interested in how we spent the weekend in the village :) please follow the link [link-1]

Staphylococcal bacteriophage. Pediatric medicine

Please tell me how to give a staphylococcal bacteriophage to a 2-year-old child. My son was found to have Staphylococcus aureus in his throat with sensitivity to this bacteriophage. We bought a 20 ml bottle. But there are no instructions for it. How to use it? Give it in a spoon? In what quantity? Or what to do with it?

STAPHYLOCOCC. Pediatric medicine

Today I received the test results. Staphylococcus was found in the amount of 1 colony. Please answer if anyone knows if this is a lot or not. Otherwise, the doctor prescribed a staphylococcal phage, but it seems like if there is only a small amount of staphylococcus, then it can be cured with more natural remedies, I don’t want to disturb the intestinal microflora. My son is 1 month old, thanks in advance to everyone who answers.

Who was found in the mother or in the child? Child's age? What Staphylococcus epidermidis, aureus, greenish?

iHerb for babies and their mothers :).

iHerb for babies – part 2 :).

I continue to share useful things for little ones that I found on Iherb (my daughter is one year old). The first review on this topic is on my blog. Water for colic – or in our opinion, “dill water” (made from fennel). Just a necessary product for babies from birth to 3-4 months! During my infancy, something similar was sold in all pharmacies, and my mother actively gave me water. Now dill water almost impossible to find, more and more chemical agents. But no remedies helped my daughter.

What is wrong with mother's milk? Mother's illnesses during infancy.

In most cases, despite the “dirty” milk, the doctor advises to continue breastfeeding if there are no signs of mastitis: sometimes the benefits of breastfeeding are greater than the harm from bad bacteria. At the same time, the mother is prescribed a course of treatment, and the child is given prophylaxis against dysbacteriosis. As a rule, when treating a nursing woman, antibiotics are avoided, giving preference to general restoratives, bacteriophages and herbal antiseptics (such as chlorophyllipt and rotokan). Before treatment, you should check whether chlorophyllipt and other medications cause allergies in the baby, and at the end, to maintain normal intestinal flora, the mother is prescribed the drugs “Bifidumbacterin” or “Primadofilus”. And only if all these remedies do not have an effect, the doctor prescribes antibiotics approved for lactation.

Before treatment, you should check whether chlorophyllipt and other medications cause allergies in the baby, and at the end, to maintain normal intestinal flora, the mother is prescribed the drugs “Bifidumbacterin” or “Primadofilus”. And only if all these remedies do not have an effect, the doctor prescribes antibiotics approved for lactation. To check the microbiological sterility of breast milk, nursing women submit it to bacteriological culture. Before expressing, you should thoroughly wash your hands and the areola area with soap and then dry with a clean towel. The first portion of milk - approximately 5-10 ml - is expressed past a sterile tube. For sowing, a trace is taken.

Dysbacteriosis in infants. Dysbacteriosis and intestinal colic.

One of the most important problems worrying parents of infants was, is and will be the state of the baby’s digestive organs. It’s not surprising - after all, the development and formation of immunity, and even the mood of the baby, depend on how the child eats, on how his intestines function. The baby himself, at the slightest problem with digestion, loudly signals this, instilling even greater anxiety in his parents. So what is behind the majority of s.

Staphylococcus aureus in infants.. Breastfeeding

I decided to start researching this topic. And I had questions. Why did you decide to do a stool test that showed staphylococcus? How many weeks, months was the child? Which indicator is considered normal and which pathology for infant in this category? Maybe someone knows who set these parameters and how and on what children and at what age? What will happen (according to doctors) if it is not treated? Did the mother have staphylococcus? Is it possible that staphylococcus was brought in at the hospital?

* 10 in the fourth. We were treated with a bacteriophage. The herd seemed to be better. Then - the second wave, in addition to constipation, my tummy also began to hurt. The second culture, in addition to the staf, revealed Klebsiela, which is just about constipation and greenery. This is such a hodgepodge. It seems that the analysis showed that they are sensitive to phages (there are strains that cannot be removed by anything). Let's see what happens next. Probiotics were prescribed along with the phages. In a month there will be a repeat seeding. I'll tell you.

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Diseases of bacterial etiology are most often treated with antibacterial drugs who have wide range actions. To selectively destroy pathogenic agents, it is recommended to use bacteriophages. Such drugs have many advantages compared to other medications. A complex bacteriophage is a medicine that contains several types of bacteriophages. Let's take a closer look at the mechanism of action of this medicine.

What are bacteriophages?

Every ailment needs specific treatment. To pick up correct method therapy, it is important to determine the type of pathogen. To combat bacterial pathologies, which differ severe course and consequences, doctors often prescribe bacteriophages. These drugs are useful for human body viruses that use harmful bacteria to reproduce and continue their life activity. At the same time they provide negative impact only and do not affect the functioning of organs and systems.

Unlike antibiotics, bacteriophages do not destroy beneficial microflora and do not cause the development of dysbacteriosis. The drugs can be taken on a long-term basis and not be afraid of the emergence of resistance of pathogenic microorganisms to the active ingredients.

In pediatric practice, polyvalent bacteriophage is often used. Reviews (for children the medicine is prescribed after diagnosis) from specialists confirm the effectiveness of the drug, provided that the type of pathogen is accurately determined. To do this, before starting therapy, it is necessary to undergo laboratory diagnostics. Bacteriophages are considered to be as powerful drugs as antibiotics.

instructions for use

Reviews from patients and doctors confirm the high therapeutic effectiveness of this medication. Unlike others, it contains several types of beneficial viruses, which allows the medicine to fight several pathological pathogens at once. The production of the medicine is carried out by the Russian pharmaceutical company"Microgen".

Pyobacteriophage is available in the form of a solution, packaged in ampoules (5 and 10 ml) and bottles (20 ml). The method of application of the liquid depends on the location of the inflammatory process. The medicine contains a mixture of bacteriophages obtained during the lysis of cells of various bacteria: Klebsiella, Streptococcus, Escherechia coli, Proteus, Staphylococcus. The complex bacteriophage additionally contains a sterile phagolysate of enterococci. Depending on the etiology of the disease, the drug can be used for oral and external use.

Indications for use

For various purulent and inflammatory pathologies, it is recommended to use polyvalent bacteriophage for treatment. Reviews and instructions for the medicine warn patients that they take it only as prescribed by a specialist. Indications for prescription are the following pathological conditions:

  • diseases of the ENT organs (tracheitis, bronchitis, otitis, tonsillitis, laryngitis);
  • inflammatory processes in genitourinary system(pyelonephritis, cystitis, colpitis, adnexitis, urethritis);
  • skin diseases complicated by secondary bacterial infection;
  • infections of the digestive tract (dysbacteriosis, cholecystitis);
  • abscesses, burns, boils, carbuncles, phlegmon;
  • ophthalmological pathologies (conjunctivitis, purulent infections).

A drug with a similar composition, complex bacteriophage, has the same indications for use. The instructions also allow it to be used to prevent infections after surgery. During the treatment period, there is no need for additional use of probiotics. Pyobacteriophages are suitable for the treatment of indolent bacterial infections.

How to take?

The dosage required in a particular case is determined only by the attending physician. It will depend on the diagnosis and the age of the patient. The method of administration of the medicine also depends on the type pathological process. For purulent-inflammatory diseases, the solution is indicated to be taken orally. Local use of the drug is possible in the form of irrigation, lotions and tampons. More effective is complex application polyvalent bacteriophage.

For the treatment of pathologies of the ENT organs, the product is used for rinsing, instilling nasal and ear cavity. Positive result gives the use of turundas moistened with a solution. They are inserted into the ear canals with extreme care so as not to damage the integrity of the eardrums. The procedure is repeated at least three times a day. For tonsillitis, the medication is used to rinse the mouth.

When treating diseases of the gastrointestinal tract, complex bacteriophage is taken orally. The patient is first advised to undergo a stool test, which will help determine the sensitivity of the pathogen to active components. For treatment inflammatory processes urinary system, the medicinal liquid is injected into the bladder using a catheter. To enhance therapeutic effect Doctors may additionally prescribe bacteriophages in tablet form.

Application in gynecology

Majority women's diseases occurs against the background of infection by pathogenic microorganisms. You can cope with the disease and suppress the vital activity of bacteria not only with the help of antibiotics, which also have a negative effect on the body. Inflammations respond well to treatment with less dangerous medications. One of these drugs is complex bacteriophage.

Instructions for use indicate that the solution is used for introduction into the vaginal or uterine cavity. The product helps to cope with Positive dynamics are observed when treating wounds and ulcers on the mucous surface with the medicine. It prevents you from reproducing harmful bacteria and reduces the inflammatory process.

Features of application

In order for the drug to really help, before starting therapy it is important to undergo an examination and determine the type of bacteria that provoked the development of the disease. A bacteriophage, consisting of several varieties of viruses, is often prescribed when several types of microbes are detected.

Can the drug be given to children?

One of the most safe medicines Complex bacteriophage is used to treat various diseases in children. It can even be used to treat severe pathologies of bacterial etiology in newborns. Up to 6 months it is recommended to give 5 ml of solution three times a day. When regurgitating, it is better to administer the medicine into the body using an enema. In this case, the dose is increased to 10 ml.

Children from 6 to 12 months of age should be given no more than 10 ml of solution when administered orally. Parents of babies note that at the beginning of therapy, side effects such as diarrhea and regurgitation often occur. If such phenomena are not observed, the medicine can be mixed with breast milk or formula.

Children over 8 years of age and adults are prescribed the drug to take 30 ml three times a day. When treating wounds skin must be pre-treated with an antiseptic solution.

When treating premature babies, the method of high enemas using special catheters is used. The duration of treatment with bacteriophages will depend on the diagnosis given to the child and the severity of his condition. Positive dynamics are usually observed within 7-14 days after the start of therapy.

Are there any contraindications?

This is one of the few drugs that does not have any contraindications for use. To prevent the development side effects You should first consult with a specialist regarding the treatment regimen and dosage of pyobacteriophage.

If storage rules are not followed, it is prohibited to use the medicine for treatment. The therapeutic properties of bacteriophages are preserved only if, after opening the bottle, it is stored at certain temperatures in the refrigerator. If a small amount of liquid is needed for treatment, you should use a sterile syringe.

Polyvalent bacteriophage: reviews from doctors

Medicines based on beneficial viruses have been used in various fields of medicine for quite a long time, although they have not become as popular as antibiotics. Experts strongly recommend using them only after laboratory diagnostics. This will help you choose the necessary one or a mixture of them for the treatment of a specific disease.

The polyvalent bacteriophage, the photo of which is presented above, is actively used for treatment infants and pregnant women. If infection with enterococci is detected, a complex bacteriophage should be purchased for a course of therapy.

None of the existing bacteriophages have structural analogues. If necessary, the doctor can select a drug that has a similar therapeutic effect as a substitute.