Drug with vasoconstrictor effect for local use in ophthalmology
◊ Eye drops transparent, colorless.
Excipients: boric acid - 12.3 mg, sodium tetraborate (borax) - 0.25 mg, sodium chloride - 2.23 mg, liquid water - up to 1 ml.
0.5 ml - transparent ampoules for single use from low-density polyethylene, soldered in the form of a strip (5) - strips (2) - paper/PE/aluminum/film bags (1) - cardboard packs.
Alpha adrenergic agonist. Tetrizoline stimulates α-adrenergic receptors of the sympathetic nervous system, does not provide or provides weak effect to β-adrenergic receptors. Being an adrenomimetic amine, tetrizoline has a vasoconstrictor effect and reduces tissue swelling.
The effect of the drug begins 60 seconds after instillation and lasts 4-8 hours.
When applied topically, systemic absorption is possible in patients with damage to the mucous membrane and epithelium.
Detailed pharmacokinetic studies during use eye drops were not carried out.
- to relieve swelling and hyperemia of the conjunctiva caused by exposure to chemical and physical factors(smoke, wind, dust, chlorinated water, light, cosmetics, contact lenses), as well as those arising from allergic reactions, such as hay fever.
— childhood up to 2 years;
— increased sensitivity to the components of the drug.
WITH caution the drug should be used in patients with severe cardiovascular diseases (for example, coronary artery disease, arterial hypertension), pheochromocytoma, prostatic hyperplasia, hyperthyroidism, diabetes mellitus, porphyria, dry rhinitis, keratoconjunctivitis sicca, glaucoma and in patients receiving MAO inhibitors or other drugs that can increase blood pressure.
The use of the drug for angle-closure glaucoma is contraindicated. For other types of glaucoma, the drug is used with extreme caution and under the supervision of a physician.
Locally. Adults and children over 2 years old 1 drop into the affected eye 2-3 times a day.
Use of the drug for more than 4 days should only be done under the supervision of a physician.
Instructions for using ampoules for single use
Each ampoule of Vizin Classic is intended for single use only. The drug should be used immediately after opening the ampoule. The amount of the drug in one ampoule is sufficient for a single injection into both eyes.
1. Break off 1 ampoule from the strip, and put the remaining ampoules back into the foil bag.
2. Then open the ampoule by unscrewing the upper, unfilled part of the ampoule.
3. Instill the drug into the conjunctival sac, lightly pressing on the filled part of the ampoule.
Very often (>1/10), often (>1/100, 1/10), infrequently (>1/1000,<1/100), редко (>1/10 000, <1/1000) и очень редко (<1/10 000).
Uncommon: reactive hyperemia, burning sensation, dry mucous membrane, systemic disorders (for example, palpitations, headache, tremor, weakness, sweating and increased blood pressure). Blurred vision, irritation of the conjunctiva, or rarely, mydriasis may occur. In addition, systemic adrenomimetic effects are infrequently observed.
In some cases After long-term use of tetrizoline, keratinization of the epithelium (xerosis) of the conjunctiva with occlusion of the lacrimal openings and epiphora has been reported.
Symptoms
Excessive systemic absorption of alpha-adrenomimetic imidazole derivatives can lead to CNS depression, manifested by drowsiness, low body temperature, bradycardia, shock-like hypotension, apnea and coma.
Symptoms of overdose are mydriasis, nausea, cyanosis, fever, convulsions, tachycardia, arrhythmia, cardiac arrest, increased blood pressure, pulmonary edema, respiratory dysfunction, and mental disorders.
The risk of overdose symptoms associated with drug absorption is especially high in newborns and young children when drops are swallowed, which may result in central nervous system disorders, as well as respiratory depression and collapse.
The toxic dose of tetrizoline is 0.01 mg/kg body weight.
Treatment
If any symptoms of overdose appear, consult a doctor immediately.
In case of overdose, activated charcoal, gastric lavage, oxygen inhalation, antipyretics and anticonvulsants are prescribed. To lower blood pressure, use phentolamine 5 mg in saline slowly intravenously or 100 mg orally. Vasopressor agents are contraindicated in patients with low blood pressure. In case of symptoms caused by blockade of m-cholinergic receptors, the antidote physostigmine is used.
The drug Vizin Classic should not be used simultaneously with MAO inhibitors such as tranylcypromine, tricyclic antidepressants, or drugs that increase blood pressure. Combination therapy with these groups of drugs can lead to increased vasoconstrictor effects and increased blood pressure.
Before instilling the drug, it is necessary to remove contact lenses and install them 15 minutes after instillation. It is necessary to avoid direct contact of the drug with soft contact lenses due to possible disruption of their transparency.
It is possible to develop reactive hyperemia of the conjunctiva and nasal mucosa (medicinal rhinitis) due to improper use of the drug.
The patient should be informed that if intense pain in the eyes, severe acute or unilateral redness of the eyes, headache, blurred vision, spots before the eyes or double vision occurs, it is necessary to immediately consult a doctor.
If irritation or hyperemia is associated with serious ocular diseases, such as infection, foreign body or chemical trauma to the cornea, consultation with an ophthalmologist is necessary.
The patient should be informed that if the medicine has become unusable or has expired, it should not be thrown into wastewater or on the street. The medicine must be placed in a bag and placed in the trash. These measures will help protect the environment.
Impact on the ability to drive vehicles and operate machinery
In rare cases, blurred vision may occur after using eye drops, which may affect your ability to drive or operate machinery.
There are no data on the penetration of the drug through the placenta and into breast milk. Considering the possibility of developing systemic side effects, the drug can be used during pregnancy and breastfeeding only if, in the opinion of the doctor, the expected benefit to the mother outweighs the potential risk to the fetus and child.
Contraindicated for use in children under 2 years of age.
Long-term use and overdose of the drug should be avoided, especially in children.
The drug is approved for use as an over-the-counter product.
The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 2 years.
After a single use of the drug Vizin Classic, the unused contents of the ampoule must be disposed of.
Groups of adrenergic agonists that have anti-edematous and antispasmodic effects.
The drops contain active substances that begin to act within the first minutes after instillation.
The product is applied topically and used as a vasoconstrictor, which also relieves swelling and inflammation.
Attention! The only negative feature of the drug is its ability to cause addiction with long-term use, and in such cases side effects may occur.
Before the introduction of the drug Visine Alergy, which is used to relieve allergic symptoms, this medicine was simply called Visine.
Currently, for convenience, the drops are given the commercial name “Visin Classic”.
The main active ingredient of the drops, tetrizoline hydrochloride, has a stimulating effect on alpha-adrenergic receptors, resulting in redness disappears and irritation disappears, and eye swelling decreases.
The effect after instillation lasts up to eight hours, after which repeated instillation of the drug is required.
Following the instructions for use, Visine classic can be used in children from the age of six years, drops are instilled two to four times a day, 1-2 drops.
If it is necessary to use classic Visine for up to six years, treatment with these drops should only be carried out under the supervision of an ophthalmologist, and instillation is prohibited for children under two years of age.
Considering that this drug quickly becomes addictive, as a result of which the effect of its use is lost and side effects may occur, It is unacceptable to use the drug for more than four days in a row, and if necessary, continue treatment, you must take a break for at least one or two days.
The main purpose of the drops is elimination of symptoms characteristic of different types of allergies, including hay fever and allergic reactions due to constant wearing of contact optics.
Reference! Visine classic also eliminates itching, burning, and irritation of the organs of vision when cosmetics, smoke or chlorinated water get into them.
The product also neutralizes the negative effects of prolonged exposure to sunlight on the eyes.
Should exercise caution when used concomitantly with medications containing atropine and having anticholinergic activity: in this case, an increase in their effect may be observed.
In all other cases, the combined use of Visine and other drops is permissible, but the interval between their instillations should be at least 10 minutes.
The official instructions for use of Visine classic mention the following contraindications:
For diabetes mellitus and coronary heart disease, monitoring by the attending physician who prescribes Visine is required.
Side effects may include itching, burning, and mild blurred vision. and minor allergic reactions (such signs appear immediately after instillation and pass quickly).
Visine classic is prescribed to pregnant women and nursing mothers, but only in cases if the positive result expected from the use of drops is justified, and the risk of negative effects on the body of the fetus or child will be minimal.
In addition to the active ingredient tetrizoline hydrochloride, the drops also contain The following additional components are included:
Reference! There are two forms of classic Visine: ampoules and a standard dropper bottle.
Ampoules are designed for one-time use for two eyes.
The bottles have a volume of 15 milliliters, and with a standard course of treatment this capacity will last for about a month.
Storage conditions for classic Vizine are standard, as is the case with most ophthalmic drugs: an unopened bottle can be kept at temperatures up to +30 degrees for three years.
Content printed container must be used in the next thirty days, and the remaining drops unused during this time must be disposed of.
Due to the fact that the drug cannot be used for some contraindications, it is sometimes replaced with analogues, but you cannot choose them yourself: before that You should definitely consult your doctor.
Such analogues in action (and sometimes in composition) include:
Classic Visine is produced by several pharmaceutical companies, so its price can vary greatly in different pharmacy chains and in different regions.
The lowest price in pharmacies recorded in peripheral regions is 130 rubles per bottle, the highest figure is 430 rubles. In most pharmacies, Vizine classic can be found at a price in the range of 300-350 rubles.
The drug is not intended for long-term use, and there is no time for the body to adapt to it: if classic Visine does not work on the first day, there is no point in using it in the future.
Instillation cannot be carried out for longer than four days., since the drug is not eliminated from the body very quickly, accumulating in tissues and entering the blood, and as a result of prolonging the course of treatment overdose may occur.
It shows up in such signs as:
In such cases, it is necessary to take emergency gastric lavage measures, and then drink several tablets of activated carbon.
in plastic dropper bottles of 15 ml; 1 bottle in a cardboard pack.Pharmacological effect - alpha-adrenomimetic.
At a temperature not exceeding 30 °C.
Keep out of the reach of children.
3 years. The contents of an open bottle should be used within 4 weeks.
Do not use after the expiration date stated on the package.
Active ingredient: tetrizoline hydrochloride 0.5 mg/ml (0.05%); excipients: boric acid, sodium chloride, disodium edetate, benzalkonium chloride solution 50%, sodium borate, purified water.
transparent colorless solution.
Tetrizoline is a sympathomimetic drug that stimulates alpha-adrenergic receptors of the sympathetic nervous system, but has no or weak effect on beta-adrenergic receptors. As a sympathomimetic amine, tetrizoline has a vasoconstrictor effect and reduces tissue swelling.
The effect begins 60 seconds after instillation and lasts 4-8 hours.
When applied topically, it is practically not absorbed. Detailed pharmacokinetic studies have not been conducted following topical application of eye drops.
For adults and children over 2 years of age, it is prescribed to relieve swelling and hyperemia of the conjunctiva (redness of the eyes) that occurs due to allergies or caused by exposure to chemical and physical factors (smoke, dust, chlorinated water, light, cosmetics, contact lenses).
Children under 6 years of age are prescribed under the supervision of a physician.
Children under 2 years of age.
The drug "Vizin®" should not be prescribed to patients with hypersensitivity to the components of the drug, patients with closed-angle glaucoma and endothelial epithelial dystrophy of the cornea.
Considering the risk of general reactions, the drug can be used during pregnancy and lactation only if, in the opinion of the doctor, the expected benefit outweighs the possible risk.
1 or 2 drops into the affected eye 2-3 times a day.
When using Vizin®, in rare cases, a burning sensation, redness of the eyes, pain in the eye, tingling in the eye, blurred vision, irritation of the conjunctiva and dilation of the pupil may occur. If any of the above symptoms occur, consult a doctor. Systemic effects may occur (rapid heartbeat, headache, tremor, weakness, sweating, increased blood pressure).
Isolated cases of blindness have been reported, however, a cause-and-effect relationship with the drug has not been established.
When used in accordance with the instructions, the risk of overdose is minimal.
However, in case of careless entry into the gastrointestinal tract (GIT), the following symptoms of overdose are possible: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmia, cardiac arrest, increased blood pressure, pulmonary edema, respiratory dysfunction, central nervous system function. nervous system, coma.
The risk of overdose symptoms associated with absorption of the drug is high in newborns and young children, especially if swallowed. Isolated cases of decreased blood pressure, bradycardia, drowsiness, and decreased body temperature have been reported.
There is no known antidote for tetrizoline hydrochloride.
In case of overdose, activated charcoal, gastric lavage, oxygen inhalation, antipyretics and anticonvulsants are prescribed. To lower blood pressure, use phentolamine 5 mg in saline solution slowly intravenously or 100 mg orally. Vasopressor agents are contraindicated in patients with low blood pressure.
If any symptoms of overdose appear, consult a doctor immediately!
Concomitant use of MAO inhibitors and tricyclic antidepressants can lead to an increased vasoconstrictor effect and an increase in blood pressure.
Contact lenses should be removed before instillation of the drug and installed after approximately 15 minutes.
It is advisable to use the drug "Vizin®" only for mild eye irritation. If the condition does not improve within 48 hours or if irritation and redness persist or increase, you should discontinue the drug and consult a doctor. If you experience intense pain in the eyes, headaches, loss of vision, sudden appearance of “floating” spots in front of the eyes, redness of the eyes, pain when exposed to light, or double vision, you should immediately consult a doctor. Do not use Vizin® if irritation or redness is associated with serious diseases of the organ of vision: infection, foreign body or chemical injury to the cornea.
If the medicine has become unusable or has expired, do not pour it into wastewater or throw it outside! Place the medication in a bag and place it in the trash. These measures will help protect the environment!
INFLUENCE ON THE ABILITY TO DRIVE A VEHICLE AND USE EQUIPMENT
In rare cases, after using Vizin® eye drops, pupil dilation is observed and blurred vision occurs, which can affect the ability to drive a car and operate machinery.
In patients with severe cardiovascular diseases (coronary heart disease, arterial hypertension, arrhythmias, aneurysm), hyperthyroidism. pheochromocytoma, diabetes mellitus and in patients receiving monoamine oxidase inhibitors or other drugs,
capable of increasing blood pressure. Before using the drug, you should consult your doctor.
Eye drops 0.05%. 15 ml of the drug in a plastic bottle with a drip device and a screw cap with a polypropylene tape - first opening control. One bottle with instructions for use in a cardboard box.
Store at a temperature not exceeding 30°C. Keep out of the reach of children.
3 years. Do not use the drug after the expiration date indicated on the package! The contents of an open bottle should be used within 4 weeks.
Over the counter.
Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.
The instructions for the drug Vizin Classic are included in the catalog of medicines presented on our information website. If you have information about the effectiveness of this medication, please leave a review. Be healthy!
Manufacturers: Keata Pharma Inc. (Canada)
Active ingredients
Pharmacological action
Adults and children over 2 years of age - to relieve swelling and hyperemia of the conjunctiva (redness of the eyes) resulting from allergies or caused by exposure to chemical and physical factors (smoke, dust, chlorinated water, light, cosmetics, contact lenses).
Children under 6 years of age are prescribed under the supervision of a physician.
eye drops 0.05%; plastic dropper bottle 15 ml, cardboard pack 1;
Alpha adrenergic agonist. Tetrizoline stimulates β-adrenergic receptors of the sympathetic nervous system, but has no or weak effect on β-adrenergic receptors. It has a vasoconstrictor effect and reduces tissue swelling.
The effect of the drug begins 60 seconds after instillation and lasts 4-8 hours.
When applied topically, it is practically not absorbed. Detailed pharmacokinetic studies have not been conducted following topical application of eye drops.
Considering the risk of general reactions, the drug can be used during pregnancy and lactation only if, in the opinion of the doctor, the expected benefit to the mother outweighs the possible risk to the fetus or child.
Hypersensitivity to the components of the drug;
Angle-closure glaucoma;
Endothelial-epithelial dystrophy of the cornea;
Children under 2 years of age.
Use caution in case of the following diseases and conditions:
Severe cardiovascular diseases (coronary artery disease, arterial hypertension, arrhythmia, aneurysm);
Hyperthyroidism;
Pheochromocytoma;
Diabetes mellitus;
Combination with MAO inhibitors or other drugs that can increase blood pressure.
When using the drug Visin Classic, in rare cases, a burning sensation, redness of the eyes, pain in the eye, tingling in the eye, blurred vision, irritation of the conjunctiva and dilation of the pupil may occur.
If the above symptoms appear, you should consult a doctor.
Conjunctivally.
1 or 2 drops into the affected eye 2-3 times a day. Continuous use of the drug for more than 4 days is not recommended.
Rules for using a dropper bottle
1. Remove the cap from the dropper bottle and turn the bottle over.
2. Do not touch the tip of the bottle to any surfaces.
3. After use, screw on the cap of the dropper bottle.
Symptoms: when used in accordance with the instructions, the risk of overdose is minimal. However, in case of accidental exposure to the gastrointestinal tract, the following symptoms of overdose are possible: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmia, cardiac arrest, increased blood pressure, pulmonary edema, impaired respiratory function, central nervous system function and coma. The risk of overdose symptoms associated with absorption of the drug is high in newborns and young children, especially if swallowed.
Treatment: administration of activated carbon, gastric lavage, oxygen inhalation, administration of antipyretics and anticonvulsants. To lower blood pressure, use phentolamine 5 mg in saline solution (iv, slowly) or 100 mg (orally). Vasopressor agents are contraindicated in patients with low blood pressure. There is no known antidote for tetrizoline hydrochloride.
If any symptoms of overdose appear, consult a doctor immediately!
Not studied.
Contact lenses should be removed before instillation of the drug and installed after approximately 15 minutes.
It is advisable to use Vizin Classic only for mild eye irritation. If the condition does not improve within 48 hours or if irritation and redness persist or increase, you should discontinue the drug and consult a doctor. If you experience intense eye pain, headache, loss of vision, sudden appearance of floaters in front of your eyes, red eyes, pain when exposed to light, or double vision, you should immediately consult a doctor.
You should not use Visin Classic if irritation or redness is associated with serious diseases of the organ of vision: infection, foreign body or chemical injury to the cornea.
If the medicine has become unusable or has expired, do not pour it into wastewater or throw it outside. It must be placed in a bag and placed in a trash container. These measures will help protect the environment.
Impact on the ability to drive a car and operate machinery. In rare cases, after using Visin Classic eye drops, the pupil may dilate and blurred vision may occur, which may affect the ability to drive a car or operate machinery.
Before instilling the drug, it is necessary to remove contact lenses and install them approximately 15 minutes after instillation.
It is advisable to use the drug only for mild eye irritation. The patient should be warned that if the condition does not improve within 48 hours or if irritation and hyperemia persist or increase, the drug should be discontinued and consult a doctor.
The patient should be informed that if intense pain in the eyes, headache, loss of vision, sudden appearance of “floating” spots in front of the eyes, redness of the eyes, pain when exposed to light or double vision occurs, it is necessary to immediately consult a doctor.
The drug should not be used if irritation or hyperemia is associated with serious diseases of the organ of vision, such as infection, foreign body or chemical trauma to the cornea.
The patient should be informed that if the medicine has become unusable or has expired, it should not be thrown into wastewater or on the street. The medicine must be placed in a bag and placed in the trash. These measures will help protect the environment.
Impact on the ability to drive vehicles and operate machinery
In rare cases, after using eye drops, pupil dilation and blurred vision may occur, which may affect the ability to drive a car or operate machinery.
List B.: At a temperature not exceeding 30 °C.
S Sense Organs
S01 Drugs for the treatment of eye diseases
S01G Decongestants and antiallergic drugs
S01GA Sympathomimetics used as decongestants
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